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Journals / Türk Biyokimya Dergisi / 2019 / Cilt: 44 - Sayı: 4

Serum fetuin-A levels and association with hematological parameters in chronic kidney disease and hemodialysis patients

Kronik böbrek hastalığı ve hemodiyaliz hastalarında serum fetuin-A seviyeleri ve hematolojik parametrelerle ilişkisi

Eray ATALAY
Hayriye ERMAN
Aybala Erek TOPRAK
İlyas DURAN
Fetullah GERİN
Fırat KORLAELÇİ
Ümmühan ÖZTÜRK
Pages
517–523
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Determination of serum fetuin-A,NLR and MPV might be useful to assess inflammation inCKD and hemodialysis patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The objective of the current study is to examine theassociation between serum fetuin-A concentrations andsome other inflammation markers neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV) and C reactive protein (CRP) in patients with chronic kidney disease(CKD) and hemodialysis.Methods: The study subjects are composed of healthyvolunteers (n = 47) and two patient groups; CKD patients(n = 26) and hemodialysis patients (n = 33).
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Key Findings & Data:Also, complete blood count parameters wereanalyzed and NLR was calculated.Results: There were significant differences in serumfetuin-A concentrations, NLR and MPV values among three groups (p < 0.001, p < 0.001, p < 0.001).
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Conclusion & Impact:Determination of serum fetuin-A,NLR and MPV might be useful to assess inflammation inCKD and hemodialysis patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: The objective of the current study is to examine theassociation between serum fetuin-A concentrations andsome other inflammation markers neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV) and C reactive protein (CRP) in patients with chronic kidney disease(CKD) and hemodialysis.Methods: The study subjects are composed of healthyvolunteers (n = 47) and two patient groups; CKD patients(n = 26) and hemodialysis patients (n = 33). We measuredserum glucose, urea, creatinine, total protein, albumin,sodium, potassium, calcium, phosphorus, iron, alkaline phosphatase, parathyroid hormone, ferritin andCRP levels by auto-analyzer and fetuin-A levels by ELISAmethod. Also, complete blood count parameters wereanalyzed and NLR was calculated.Results: There were significant differences in serumfetuin-A concentrations, NLR and MPV values among three groups (p < 0.001, p < 0.001, p < 0.001). The correlation analyses revealed that fetuin-A negatively correlatedwith urea, creatinine, ferritin, and CRP concentrations (r:0.349, 0.367, 0.399, 0.550, respectively, p < 0.05).Conclusion: Fetuin-A is lower in CKD and hemodialysispatients than the control group; supporting as a negativeacute phase reactant. Determination of serum fetuin-A,NLR and MPV might be useful to assess inflammation inCKD and hemodialysis patients.

Özet

Amaç: Bu çalışmanın amacı kronik böbrek hastalığı (KBH) ve hemodiyaliz hastalarında serum Fetuin-A seviyeleri ve nötrofil lenfosit oranı (NLR), ortalama trombosit hacmi (MPV) ve C reaktif protein (CRP) gibi inflamatuvar parametreler arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Çalışma grubu 47 sağlıklı gönüllü ile 26 KBH ve 33 hemodiyaliz hastadan oluşmaktadır. Bu çalışma için serum glukoz, üre, kreatinin, total protein, albümin, sodyum, potasyum, kalsiyum, fosfor, demir, alkalen fosfataz, paratiroid hormon, ferritin ve CRP seviyeleri otoanalizör ile, fetuin-A konsantrasyonu ise ELISA metodu ile ölçüldü. Ayrıca tam kan sayımı yapıldı ve NLR hesaplandı. Bulgular: Üç grup arasında Fetuin A, NLR ve MPV değerleri açısından anlamlı fark vardı (p < 0.001, p < 0.001, p < 0.001). Korelasyon analizinde fetuin A’nın üre, kreatinin, ferritin ve CRP ile negatif ilişkili olduğu görüldü (r: 0.349, 0.367, 0.399, 0.550, sırasıyla, tüm p < 0.05). Sonuç: Fetuin-A KBH ve hemodiyaliz hastalarında kontrol grubuna göre daha düşük bulundu. Bu da negatif akut faz reaktanı olduğunu destekliyordu. NLR ve MPV değerleri kontrol grubuna göre KBH grubunda yüksekti. Fetuin A, NLR, MPV değerlerinin KBH ve hemodiyaliz hastalarında belirlenmesi inflamasyonun değerlendirilmesinde yararlı olabilir.

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Cite This Article

ATALAY, E., ERMAN, H., TOPRAK, A. E., DURAN, İ., GERİN, F., KORLAELÇİ, F., ÖZTÜRK, Ü. (2022). Serum fetuin-A levels and association with hematological parameters in chronic kidney disease and hemodialysis patients. Türk Biyokimya Dergisi, Cilt: 44 - Sayı: 4, 517–523. https://ajindex.com/articles/620888

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