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Journals / Türk Biyokimya Dergisi / 2019 / Cilt: 44 - Sayı: 5

Association between serum vitamin D level and liver MRI T2 star in patients with β-thalassemia major

β-Talasemi Major Hastalarında Karaciğer MRI T2 skoru ile Serum Vitamin D düzeyleri arasındaki İlişki

Belkıs KOÇTEKİN
Sevcan UĞUR
Selen BOZKURT
Erdal KURTOĞLU
Ayşegül UĞUR KURTOĞLU
Pages
594–598
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Vitamin D deficiency (

📌 3 Key Takeaways

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Objective & Hypothesis:AbstractBackground: Iron overloaded Beta Thalassemia major (β-TM) patients have a high risk of liver problems.
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Key Findings & Data:In recent years studies revealed that vitamin D level is decreased inchronic liver diseases.
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Conclusion & Impact:Vitamin D deficiency (
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

AbstractBackground: Iron overloaded Beta Thalassemia major (β-TM) patients have a high risk of liver problems. In recent years studies revealed that vitamin D level is decreased inchronic liver diseases. The present study was designed to find the association between the serum vitamin D levels and the liver iron deposition in patients with β-TM.Materials and methods: A total of 101 patients with a diagnosis of β-TM were included into this study. The patients were divided into four groups according to liver T2* MRIscores (group 1: normal, group 2: mild iron load, group 3: moderate iron load and group 4: severe iron load). Serum vitamin D was measured by chemiluminescence immunoassay method.Results: The vitamin D level was median 14 (4–91) ng/mL. There was a positive correlation between vitamin D levels and liver T2* MRI scores (r = 0.31, p < 0.05). There is a significant difference between groups 1 and 4 for vitamin D level (p < 0.05). Vitamin D deficiency (

Özet

ÖzAmaç: Beta talasemi major (β-TM) tüm dünyada sık görülen genetik bir hastalıktır. Aşırı demir yüklenmesi olan β-TM hastalarında karaciğer ve kalp problemleri sık görülmekte ve yaşam beklentisi azalmaktadır. Son yıllarda yapılan çalışmalarda kronik karaciğer hastalıkları ile düşük vitamin D düzeyleri arasındaki ilişki vurgulanmaktadır. Bu çalışmamızda β-TM hastalarında karaciğer demir birikimi ile vitamin D düzeyleri arasındaki ilişkiyi araştırdık.Gereç ve Yöntem: Çalışmaya 101 β-TM tanılı hasta dahil edildi. Hastalar karaciğer T2* MRI skoruna göre dört gruba ayrıldı. (Grup 1: normal, grup 2: hafif düzeyde demir birikimi, grup 3: orta düzeyde demir birikimi, grup 4: hafif düzeyde demir birikimi). Serum vitamin D düzeyleri kemiluminesans immunoassay yöntemi ile ölçüldü.Bulgular: Ortalama T2* skoru 5.86 ± 7.68 ms idi. Vitamin D düzeyleri ortanca 14 (4–91) ng/mL olarak ölçüldü. Vitamin D düzeyleri ile karaciğer T2* MRI skoru arasında pozitif korelasyon olduğu tespit edildi (r = 0,31, p < 0,05). Grup 1 ve 4 arasında vitamin D düzeylerinin anlamlı düzeyde farklı olduğu bulundu (p < 0,05). Vitamin D eksikliği (

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Cite This Article

KOÇTEKİN, B., UĞUR, S., BOZKURT, S., KURTOĞLU, E., KURTOĞLU, A. U. (2022). Association between serum vitamin D level and liver MRI T2 star in patients with β-thalassemia major. Türk Biyokimya Dergisi, Cilt: 44 - Sayı: 5, 594–598. https://ajindex.com/articles/620875

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