Journals / Türk Biyokimya Dergisi / 2019 / Cilt: 44 - Sayı: 5

Does vitamin D prevent radiotherapy-induced toxicity?

D Vitamini Radyoterapi ile İndüklenmiş Toksisiteyi Engeller Mi?

Pages
575–577
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There is a need for studies to be done in this regard.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Vitamin D is known as the bone hormone, it is also know that it has effects on cancer because of its antiinflammatory and immunomodulatory characteristics and its effects on cytokine levels.
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Key Findings & Data:Useof 1,25[OH]2 Vitamin D3 analogs as an adjuvant immunomodulator for patients receiving radiotherapy should be evaluated.
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Conclusion & Impact:There is a need for studies to be done in this regard.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Vitamin D is known as the bone hormone, it is also know that it has effects on cancer because of its antiinflammatory and immunomodulatory characteristics and its effects on cytokine levels. It is seen that vitamin D use together with radiotherapy can have a positive effect on cancer treatment. It should be investigated whether toxicities due to radiation is prevented by vitamin D metabolites’ increasing the induction of immunomodulator cells and the capacities of immune response cells. Useof 1,25[OH]2 Vitamin D3 analogs as an adjuvant immunomodulator for patients receiving radiotherapy should be evaluated. There is a need for studies to be done in this regard.

Özet

D vitamini genel olarak kemik hormonu olarak bilinmesine rağmen, antienflamatuar ve immünmodülatör özellikleri ve sitokin seviyeleri üzerine olası etkileri nedeniyle kanser tedavisinde önemli etkileri olduğu bilinmektedir. D vitamininin radyoterapi ile birlikte kullanılmasının kanser tedavisinde olumlu etkisi olabileceği görülmektedir. Vitamin D metabolitlerinin immunomodulatör hücrelerin indüksiyonunu ve bağışıklık yanıt hücrelerinin kapasitelerini arttırmasıyla radyasyonun neden olduğu toksisitelerin önüne geçilip geçilmeyeceği araştırılmalıdır. Özellikle, 1,25(OH)2 Vitamin D3 analogların, radyoterapi uygulanılan hastalarda bir adjuvan immunomodulatuar olarak kullanılması değerlendirilmelidir. Bu konuda yapılacak çalışmalara ihtiyaç vardır.

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Cite This Article

CİHAN, Y. B. (2022). Does vitamin D prevent radiotherapy-induced toxicity?. Türk Biyokimya Dergisi, Cilt: 44 - Sayı: 5, 575–577. https://ajindex.com/articles/620861

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