Effects of SR-BI rs5888 and rs4238001 variations on hypertension

In the SR-BI rs5888 variation; normal homozygous CC and heterozygous CT carriers had anaverage 2-fold lower risk of hypertension than those carrying the TT genotype (p < 0.05).Conclusion: SR-BI rs5888 TT variant may increase hypertension risk by reducing lipid transport to the liver fromthe vessel wall.

📌 3 Key Takeaways

🎯

Objective & Hypothesis:Background: Scavenger receptor class B, type I (SR-BI),involved in reverse cholesterol pathway, is a multilipoprotein receptor and capable of binding HDL, LDL andVLDL.

📊

Key Findings & Data:Therefore, it was aimedto investigate the relationship between SR-BI rs5888 andrs4238001 variants in the patient with hypertension.Materials and methods: Seventy three subjects diagnosedwith hypertension and 76 healthy subjects constituted thepatient and control group, respectively.

💡

Conclusion & Impact:In the SR-BI rs5888 variation; normal homozygous CC and heterozygous CT carriers had anaverage 2-fold lower risk of hypertension than those carrying the TT genotype (p < 0.05).Conclusion: SR-BI rs5888 TT variant may increase hypertension risk by reducing lipid transport to the liver fromthe vessel wall.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Background: Scavenger receptor class B, type I (SR-BI),involved in reverse cholesterol pathway, is a multilipoprotein receptor and capable of binding HDL, LDL andVLDL. SR-BI may contribute to the development of hypertension due to accumulation of cholesterol in the vesselwall via transporting lipoproteins. Therefore, it was aimedto investigate the relationship between SR-BI rs5888 andrs4238001 variants in the patient with hypertension.Materials and methods: Seventy three subjects diagnosedwith hypertension and 76 healthy subjects constituted thepatient and control group, respectively. Genomic DNAwas isolated from peripheral blood samples and a realtime quantitative polymerase chain reaction protocol wasperformed to detect variations of rs5888 and rs4238001.The results were analyzed with the SPSS 22 program andp 0.05). In the SR-BI rs5888 variation; normal homozygous CC and heterozygous CT carriers had anaverage 2-fold lower risk of hypertension than those carrying the TT genotype (p < 0.05).Conclusion: SR-BI rs5888 TT variant may increase hypertension risk by reducing lipid transport to the liver fromthe vessel wall.

Özet

Amaç: Ters kolesterol yolağında görev alan çöpçü reseptör BI (SR-BI); başta HDL olmak üzere LDL ve VLDL bağlayabilen multilipoprotein reseptörüdür. SR-BI lipoproteinlerin taşınmasında görev aldığı için damar duvarında kolesterol birikimine bağlı olarak hipertansiyon gelişimine katkıda bulunabilir. Bu sebeple SR-BI rs5888 ve rs4238001 varyantlarının hipertansiyonla ilişkisinin incelenmesi amaçlandı. Gereç ve Yöntemler: 73 hipertansiyon tanısı konmuş hasta ve 76 sağlıklı kişi, sırasıyla hasta ve kontrol grubunu oluşturdu. Kandan genomik DNA izolasyonu yapılarak, rs5888 ve rs4238001 varyasyonlarının tespiti için RealTime kantitatif PCR protokolü gerçekleştirildi. Sonuçlar SPSS 22 programı ila analiz edildi ve p 0.05). SR-BI rs5888 varyasyonunda ise normal homozigot CC ve heterozigot CT taşıyanların TT genotipi taşıyanlara göre ortalama 2 kat daha az hipertansiyon riskine sahip oldukları bulundu (p < 0.05). Sonuç: SR-BI rs5888 TT varyasyonu damar duvarından karaciğere lipid taşınımını azaltmak suretiyle hipertansiyon riskini arttırıyor olabilir.

🔖

Cite This Article

AYDOĞAN, H. Y., PENÇE, H. H., ÇAYKARA, B., ALSAADONI, H., PENÇE, S., YILDIZ, A., ŞABANÇELEBİ, S. (2022). Effects of SR-BI rs5888 and rs4238001 variations on hypertension. Türk Biyokimya Dergisi, Cilt: 44 - Sayı: 4, 549–553. https://ajindex.com/articles/620845

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (12)

Mills KT, Bundy JD, Kelly TN, Reed JE, Kearney PM, Reynolds K, et al. Global disparities of hypertension prevalence and control: a systematic analysis of population-based studies from 90 countries. Circulation 2016;134:441–50
Onat A, editor. TEKHARF 2017, Tıp Dünyasının Kronik Hastalıklara Yaklaşımına Öncülük. Toplumumuzda Kan Basıncı ve Hipertansiyon p105–119. Logos Yayıncılık, 2017. İstanbul. http://file. tkd.org.tr/PDFs/TEKHARF-2017.pdf (Last accessed: September 2018)
Durmaz C, Arslan P. Factors affecting hypertension and blood pressure in the community. Bes Diy Derg 2017;45: 278–86
Çakmak HA, Arslan E, Erdine S. Unmet needs in hypertension. Arch Turk Soc Cardiol 2009;37:1–4
Yu X, Murao K, Imachi H, Cao WM, Li J, Matsumoto K, et al. Regulation of scavenger receptor class BI gene expression by angiotensin II in vascular endothelial cells. Hypertension 2007;49:1378–84
Shen WJ, Asthana S, Kraemer FB, Azhar S. Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function. J Lipid Res 2018;59:1114–31
Gutierrez-Pajares JL, Ben Hassen C, Chevalier S, Frank PG. SR-BI: linking cholesterol and lipoprotein metabolism with breast and prostate cancer. Front Pharmacol 2016;7:338
Westhaus S, Deest M, Nguyen AT, Stanke F, Heckl D, Costa R, et al. Scavenger receptor class B member 1 (SCARB1) variants modulate hepatitis C virüs replication cycle and viral load. J Hepatol 2017;67:237–45
Eckhardt ER, Cai L, Sun B, Webb NR, van der Westhuyzen DR. High density lipoprotein uptake by scavenger receptor SR-BII. J Biol Chem 2004;279:14372–81
Liadaki KN, Liu T, Xu S, Ishida BY, Duchateaux PN, Krieger JP, et al. Binding of high density lipoprotein (HDL) and discoidal reconstituted HDL to the HDL receptor scavenger receptor class B type I. Effect of lipid association and APOA-I mutations on receptor binding. J Biol Chem 2000;275:21262–71. 11. de Beer MC, Durbin DM, Cai L, Jonas A, de Beer FC, van der Westhuyzen DR. Apolipoprotein A-I conformation markedly influences HDL interaction with scavenger receptor BI. J Lipid Res 2001;42:309–13
Hoekstra M. SR-BI as target in atherosclerosis and cardiovascular disease – a comprehensive appraisal of the cellular functions of SR-BI in physiology and disease. Atherosclerosis 2017;258:153–61
Gu X, Lawrence R, Krieger M. Dissociation of the high density lipoprotein and low density lipoprotein binding activities of murine scavenger receptor class B type I (mSR-BI