AI Summary & Key Takeaways
AI InsightSerum endocan levels in patients with HSP were inversely correlated only with activated partialthromboplastin time (APTT) (r = −0.485, p = 0.012).Conclusion: Coagulation abnormalities and increasedacute phase reactants were present in patients with HSPwhile no difference was determined in endocan levels.
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Abstract
AbstractObjective: Henoch-Schönlein purpura (HSP) is characterized by generalized vasculitis. The etiopathogenesis of the disease is unknown, but inflammation and endothelial dysfunction have been held responsible. Therefore, herein we investigated serum levels of biomarkers indicating endothelial cell damage, inflammation and coagulation in children with HSP.Materials and methods: Twenty six patients with HSP and 26 healthy children were included in the study. Routine biochemical tests and laboratory parameters showing inflammation, coagulation, and endothelial cell damage were examined in all subjects.Results: White blood cell (WBC) number, C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), neutrophil/lymphocyte rate (NLR), triglyceride, immunoglobulin A (IgA), and C3 were significantly higher in children with HSP than the controls. HDL and albumin levels were lower in the patients with HSP. Endocan levels were not significantly different between the HSP and control groups (p = 0.884). Serum endocan levels in patients with HSP were inversely correlated only with activated partialthromboplastin time (APTT) (r = −0.485, p = 0.012).Conclusion: Coagulation abnormalities and increasedacute phase reactants were present in patients with HSPwhile no difference was determined in endocan levels.
Özet
Öz Amaç: Henoch-Schönlein purpurası (HSP) jeneralize vaskülit ile karakterizedir. Hastalığın etiyopatogenezi bilinmemekte olup inflamasyon ve endotelyal disfonksiyon sorumlu tutulmaktadır. Bu nedenle çalışmamızda HSP’li çocuklarda endotel hücre hasarı, inflamasyon ve pıhtılaşmayı belirten bazı biyobelirteçlerin serum düzeyleri araştırılmıştır.Gereç ve Yöntem: Çalışmaya HSP’li 26 hasta ve kontrol grubu olarak 26 sağlıklı çocuk dahil edildi. Tüm olgularda rutin biyokimyasal testler ve inflamasyon, koagülasyon ve endotel hücre hasarını gösteren laboratuvar verileri analiz edildi.Bulgular: HSP’li çocuklarda beyaz kan hücresi (WBC) sayısı, C-reaktif protein (CRP) düzeyi, eritrosit sedimentasyon hızı (ESH), nötrofil/lenfosit (NLR) oranı, trigliserit, immünoglobulin A (IgA) ve C3 kontrol grubundan anlamlı olarak yüksek bulundu. HDL ve albümin düzeyleri ise HSP’li hastalarda daha düşüktü. Endocan düzeyleri açısından gruplar arasında anlamlı farklılık saptanmadı (p = 0.884). Serum endokan düzeyleri sadece aktive parsiyel tromboplastin zamanı (APTT) ile ters korele bulundu (r = −0.485, p = 0.012).Sonuç: HSP’li çocuklarda koagülasyon anormallikleri ve artmış akut faz reaktanları gözlenirken, bir endotel disfonksiyon belirteci olan endokan düzeylerinde anlamlı farklılık saptanmadı.