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Journals / Türk Biyokimya Dergisi / 2020 / Cilt: 45 - Sayı: 6

Probable alterations in fecal bacterial microbiota by somatostatin receptor analogs in acromegaly

[Akromegali olgularında somatostatin reseptör analoglarına bağlı olası fekal mikrobiyota değişiklikleri]

Tomris ERBAŞ
Selçuk DAĞDELEN
Muhittin SERDAR
Süleyman Nahit ŞENDUR
Annika BRİNKMANN
Andreas NİTSCHE
Engin YILMAZ
Koray ERGÜNAY
Yakut AKYÖN
Pages
695–700
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Moreover, Akkermansia mucinophila waspresent in patients under OCT treatment.Conclusion: Our preliminary results suggest that thebacterial community profile under OCT treatment mayfacilitate a colonic microenvironment for improvedglucose metabolism.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Data on bacterial diversity and microbiota alterationsin acromegaly are currently lacking.
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Key Findings & Data:The objective of this study was to determinemicrobiota alterations in patients with acromegaly and toassess the effects of somatostatin receptor analogs on gutmicrobiota.Methods: The study was designed as a cross-sectionalcase-control research and three cohorts, comprising individualswith acromegaly without medical therapy (n=5),acromegaly receiving octreotide acetate (OCT) (n=8) andhealthy controls (n=5), were evaluated.Results: No statistically-supported changes in Bacteroidetes,Firmicutes, Proteobacteria and Actinobacteriaabundance were observed.
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Conclusion & Impact:Moreover, Akkermansia mucinophila waspresent in patients under OCT treatment.Conclusion: Our preliminary results suggest that thebacterial community profile under OCT treatment mayfacilitate a colonic microenvironment for improvedglucose metabolism.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Data on bacterial diversity and microbiota alterationsin acromegaly are currently lacking. The effects ofsomatostatin receptor analogs on gut microbiota remainunknown. The objective of this study was to determinemicrobiota alterations in patients with acromegaly and toassess the effects of somatostatin receptor analogs on gutmicrobiota.Methods: The study was designed as a cross-sectionalcase-control research and three cohorts, comprising individualswith acromegaly without medical therapy (n=5),acromegaly receiving octreotide acetate (OCT) (n=8) andhealthy controls (n=5), were evaluated.Results: No statistically-supported changes in Bacteroidetes,Firmicutes, Proteobacteria and Actinobacteriaabundance were observed. Bacteroidaceae, Odoribacteraceae,Porphyromonadaceae, Prevotellaceae andAlistipes families of Bacteroidetes and Bifidobacteriumgenus of theActinobacteria phylawere detected, withoutovert differences. Variations in Clostridia, Erysipelotrichaceaeand Veillonellaceae were not significant,while Lactobacillales were increased in individualsreceiving OCT. Moreover, Akkermansia mucinophila waspresent in patients under OCT treatment.Conclusion: Our preliminary results suggest that thebacterial community profile under OCT treatment mayfacilitate a colonic microenvironment for improvedglucose metabolism. Alterations in the gut microbiotamay be a factor affecting diabetes development duringsomatostatin analog treatment in acromegalicpatients.

Özet

Amaç: Akromegali olgularında bakteri çeşitliliği ve mikrobiyota değişiklikleri konusunda bilgiler kısıtlıdır. Somatostatin reseptör analoglarının barsak mikrobiotası üzerine etkileri bilinmemektedir. Bu çalışmada akromegali olgularında mikrobiyota değişikliklerinin belirlenmesi ve somatostatin reseptör analoglarının bağırsak mikrobiyotası üzerindeki etkilerinin incelenmesi amaçlandı. Gereç ve Yöntemler: Kesitsel bir vaka-kontrol araştırması olarak planlanan çalışmada, tıbbi tedavi altında olmayan akromegali olguları (n=5), oktreotid asetat (OCT) uygulanan akromegali olguları (n=8) ve sağlıklı kontroller (n=5) değerlendirildi. Bulgular: Bacteroidetes, Firmicutes, Proteobacteria and Actinobacteria üyelerinde, gruplar arasında istatistiksel olarak anlamlı değişiklik saptanmadı. Örneklerde Bacteroidetes şubesi Bacteroidaceae, Odoribacteraceae, Porphyromonadaceae, Prevotellaceae and Alistipes ailelerinde ve Actinobacteria şubesi Bifidobacterium cinsinde bakteriler, belirgin bir farklılık göstermeden izlendi. Clostridia, Erysipelotrichaceae ve Veillonellaceae üyesi bakterilerde izlenen varyasyonlar anlamlı değilken, OCT tedavisi alan olgularda Akkermansia mucinophila saptandı ve Lactobacillales üyeleri artmış olarak izlendi. Sonuç: Ön çalışmamız, OCT tedavisi alanlarda glukoz metabolizması yönünden olumlu olarak değerlendirilebilecek bir barsak bakteri profili varlığına işaret etmektedir. Akromegali olgularında diabet gelişiminde mikrobiota değişikliklerinin de etkisi söz konusu olabilir.

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Cite This Article

ERBAŞ, T., DAĞDELEN, S., SERDAR, M., ŞENDUR, S. N., BRİNKMANN, A., NİTSCHE, A., YILMAZ, E., ERGÜNAY, K., AKYÖN, Y. (2022). Probable alterations in fecal bacterial microbiota by somatostatin receptor analogs in acromegaly. Türk Biyokimya Dergisi, Cilt: 45 - Sayı: 6, 695–700. https://ajindex.com/articles/620818

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