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Journals / Türk Biyokimya Dergisi / 2020 / Cilt: 45 - Sayı: 6

Hesperidin and eugenol attenuate cadmium-induced nephrotoxicity via regulation of oxidative stress, Bax/Bcl2 and cleaved caspase 3 expression

[Hesperidin ve öjenol, oksidatif stres, Bax/Bcl2 ve bölünmüş kaspaz 3 ekspresyonunun düzenlenmesi yoluyla kadmiyum kaynaklı nefrotoksisiteyi zayıflatır]

Rasha HÜSSEİN
Marwa KHALAF
Wafaa MOHAMED
Pages
767–775
Publication Date
2022-11-06
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

Rats received CdCl2 (5 mg/kg body weight/daily) via oral gavage for four weeks toinduce kidney toxicity.Results: The results showed that, both hesperidin & Cdand eugenol & Cd- treated groups exhibited lower serumcreatinine and urea levels as well as better kidney tissueintegrity compared to the Cd-treated group.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Cadmium (Cd) is a heavy metal that inducesnephrotoxicity through stimulating the oxidative stress inkidney cells.
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Key Findings & Data:In this study, we investigated the protectiveeffects of hesperidin and eugenol on Cd-induced nephrotoxicityand their impact on modulating oxidative stress,Bax/Bcl2 ratio and cleaved caspase 3 level.Methods: Male Wistar rats were divided into: Normalgroup; Cd-treated group; hesperidin & Cd-treated groupand eugenol&Cd-treated group.
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Conclusion & Impact:Rats received CdCl2 (5 mg/kg body weight/daily) via oral gavage for four weeks toinduce kidney toxicity.Results: The results showed that, both hesperidin & Cdand eugenol & Cd- treated groups exhibited lower serumcreatinine and urea levels as well as better kidney tissueintegrity compared to the Cd-treated group.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Cadmium (Cd) is a heavy metal that inducesnephrotoxicity through stimulating the oxidative stress inkidney cells. In this study, we investigated the protectiveeffects of hesperidin and eugenol on Cd-induced nephrotoxicityand their impact on modulating oxidative stress,Bax/Bcl2 ratio and cleaved caspase 3 level.Methods: Male Wistar rats were divided into: Normalgroup; Cd-treated group; hesperidin & Cd-treated groupand eugenol&Cd-treated group. Rats received CdCl2 (5 mg/kg body weight/daily) via oral gavage for four weeks toinduce kidney toxicity.Results: The results showed that, both hesperidin & Cdand eugenol & Cd- treated groups exhibited lower serumcreatinine and urea levels as well as better kidney tissueintegrity compared to the Cd-treated group. Moreover, theycould preserve the cellular antioxidants to normal levels aswas seen in a significantly lower malondialdehyde content,but significantly higher catalase and superoxide dismutaseactivities compared to the Cd-treated group. Furthermore,both groups significantly decreased the Cd-induced elevationin Bax/Bcl2 ratio and cleaved caspase 3 level.Conclusion: Administration of hesperidin or eugenoleffectively protected from the structural and functionalkidney damage induced by Cd exposure via antioxidantand anti-apoptotic effects.

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Cite This Article

HÜSSEİN, R., KHALAF, M., MOHAMED, W. (2022). Hesperidin and eugenol attenuate cadmium-induced nephrotoxicity via regulation of oxidative stress, Bax/Bcl2 and cleaved caspase 3 expression. Türk Biyokimya Dergisi, Cilt: 45 - Sayı: 6, 767–775. https://ajindex.com/articles/620798

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