SavedAdd your journal

Journals / Türk Biyokimya Dergisi / 2020 / Cilt: 45 - Sayı: 5

MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis

Ülseratif kolitli Türk hastalarda MICA, HLA-DRB1, HLA-DQB1 genotipleri

Fatma SAVRAN OĞUZ
Filiz AKYÜZ
Kadir DEMİR
Binnur PINARBAŞI
Sonay TEMURHAN
Çiğdem KEKİK ÇINAR
Pages
587–592
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Objectives: We aimed to determine Human LeukocyteAntigen (HLA)-DRB1, DQB1, and MHC Class I related chainA (MICA) genotypes in patients with ulcerative colitis.Methods: HLA-DRB1, HLA-DQB1, MICA genotyping ofpatient (n:85) and controls (n:100) were performed by PCRSSO Luminex (One Lambda genotyping kit).Results: We found significantly higher DRB1*01 (p:0.022,OR:0.23, CI:0.06–0.8) and MICA*0002/20/55 (p:0.03,OR:0.53, CI:0.29–0.93) alleles in control group whereasDRB1*14 (p:0.04, OR:2.25, CI:1–5.08), DRB1*15 (p:

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: We aimed to determine Human LeukocyteAntigen (HLA)-DRB1, DQB1, and MHC Class I related chainA (MICA) genotypes in patients with ulcerative colitis.Methods: HLA-DRB1, HLA-DQB1, MICA genotyping ofpatient (n:85) and controls (n:100) were performed by PCRSSO Luminex (One Lambda genotyping kit).Results: We found significantly higher DRB1*01 (p:0.022,OR:0.23, CI:0.06–0.8) and MICA*0002/20/55 (p:0.03,OR:0.53, CI:0.29–0.93) alleles in control group whereasDRB1*14 (p:0.04, OR:2.25, CI:1–5.08), DRB1*15 (p:
📊
Key Findings & Data:Objectives: We aimed to determine Human LeukocyteAntigen (HLA)-DRB1, DQB1, and MHC Class I related chainA (MICA) genotypes in patients with ulcerative colitis.Methods: HLA-DRB1, HLA-DQB1, MICA genotyping ofpatient (n:85) and controls (n:100) were performed by PCRSSO Luminex (One Lambda genotyping kit).Results: We found significantly higher DRB1*01 (p:0.022,OR:0.23, CI:0.06–0.8) and MICA*0002/20/55 (p:0.03,OR:0.53, CI:0.29–0.93) alleles in control group whereasDRB1*14 (p:0.04, OR:2.25, CI:1–5.08), DRB1*15 (p:
💡
Conclusion & Impact:Objectives: We aimed to determine Human LeukocyteAntigen (HLA)-DRB1, DQB1, and MHC Class I related chainA (MICA) genotypes in patients with ulcerative colitis.Methods: HLA-DRB1, HLA-DQB1, MICA genotyping ofpatient (n:85) and controls (n:100) were performed by PCRSSO Luminex (One Lambda genotyping kit).Results: We found significantly higher DRB1*01 (p:0.022,OR:0.23, CI:0.06–0.8) and MICA*0002/20/55 (p:0.03,OR:0.53, CI:0.29–0.93) alleles in control group whereasDRB1*14 (p:0.04, OR:2.25, CI:1–5.08), DRB1*15 (p:
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: We aimed to determine Human LeukocyteAntigen (HLA)-DRB1, DQB1, and MHC Class I related chainA (MICA) genotypes in patients with ulcerative colitis.Methods: HLA-DRB1, HLA-DQB1, MICA genotyping ofpatient (n:85) and controls (n:100) were performed by PCRSSO Luminex (One Lambda genotyping kit).Results: We found significantly higher DRB1*01 (p:0.022,OR:0.23, CI:0.06–0.8) and MICA*0002/20/55 (p:0.03,OR:0.53, CI:0.29–0.93) alleles in control group whereasDRB1*14 (p:0.04, OR:2.25, CI:1–5.08), DRB1*15 (p:

Özet

Amaç: Ülseratif kolit, kronik enflamatuvar bir bağırsak hastalığıdır. HLA alelleri, enflamatuvar bağırsak hasta lıklarının patogenezinde önemli bir rol oynar. HLA DRB1*09, DRB1*1502, DRB1*0103 ve DRB1*13 alellerinin ülseratif kolit ile ilişkili olduğu bildirilirken HLA DRB1*04 ve DRB1*08 alellerinin koruyucu olduğu bil dirilmiştir. Bakteriyel antijenler kolon lümeninde MICA ekspresyonunu indükler ve MICA geni ülseratif kolit gelişimi için önemlidir. MICA*06 ve MICA*007 alelleri Ülseratif kolit ile ilişkilendirilmiştir. Ülseratif kolitli hastalarda HLA-DRB1, DQB1, MICA genotiplerini belir lemeyi amaçladık. Gereç ve yöntemler: Hasta (n: 85) ve kontrol grubunun (n: 100) HLA-DRB1, HLA-DQB1, MICA genotiplemesi PCR-SSO Lumineks (One Lambda genotipleme kiti) yöntemiyle gerçekleştirildi. Bulgular: DRB1*01 (p: 0.022, OR: 0.23, CI: 0.06–0.8) ve MICA*0002/20/55 (p: 0.03, OR: 0.53, CI: 0.29-0.93) allelleri kontrol grubunda anlamlı olarak daha yüksek iken, DRB1*14 (p: 0.04, OR: 2.25, CI: 1–5.08), DRB1*15 (p:

🔖

Cite This Article

OĞUZ, F. S., AKYÜZ, F., DEMİR, K., PINARBAŞI, B., TEMURHAN, S., ÇINAR, Ç. K. (2022). MHC Class I related chain A (MICA), Human Leukocyte Antigen (HLA)-DRB1, HLA-DQB1 genotypes in Turkish patients with ulcerative colitis. Türk Biyokimya Dergisi, Cilt: 45 - Sayı: 5, 587–592. https://ajindex.com/articles/620785

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Gambichler T, Reich S, Banasch M, Altmeyer P. Complex extraintestinal complications of ulcerative colitis in a patient with α1- antitrypsin deficiency. Eur J Med Res 2006;11:135–8
  2. Chams S, Badran R, Sayegh SE, Chams N, Shams A, Hajj Hussein I. Inflammatory bowel disease: looking beyond the tract. Int J Immunopathol Pharmacol 2019;33:1–18
  3. Rubin DT, Ananthakrishnan AN, Siegel CA, Sauer BG, Long MD. ACG clinical guideline: ulcerative colitis in adults. Am J Gastroenterol 2019;114:384–413
  4. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998;115:182
  5. Williams DA. Inflammatory cytokines and mucosal injury. J Natl Cancer Inst Monogr 2001;29:26–30
  6. Shanahan F. Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics. Gastroenterology 2001;120:662
  7. Powrie F, Leach MW, Mauze S, Caddle LB, Coffman RL. Phenotypically distinct subsets of CD4+Tcells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol 1993;5:1461–71
  8. Uyar FA, Imeryuz N, Saruhan-Direskeneli G, Ceken H, Ozdoğan O, Tözün N, et al. The distribution of HLA-DRB alleles in ulcerative colitis patients in Turkey. Eur J Immunogenet 1998;25:293–6
  9. Ahmad T, Marshall SE, Jewell D. Genetics of inflammatory bowel disease: the role of the HLA complex. World J Gastroenterol 2006; 21:3628–35
  10. Myung SJ, Yang SK, Jung HY, Chang HS, Park J, Hong WS, et al. HLA-DRB1*1502 confers susceptibility to ulcerative colitis, but is negatively associated with its intractability: a Korean study. Int J Colorectal Dis 2002;17:233–7
  11. Gao F, Aheman A, Lu JJ, Abuduhadeer M, Li YX, Kuerbanjiang A. Association of HLA-DRB1 alleles and anti-neutrophil cytoplasmic antibodies in Han and Uyghur patients with ulcerative colitis in China. J Dig Dis 2014;15:299–305
  12. Ahmad T, Armuzzi A, Neville M, Bunce M, Ling KL, Welsh KI, et al. The contribution of human leukocyte antigen complex genes to disease phenotype in ulcerative colitis. Tissue Antigens 2003;62: 527–35
  13. Mahdi BM. Role of HLA typing on Crohn’s disease pathogenesis. Ann Med Surg (Lond) 2015;4:248–53
  14. Mohammadi M, Rastin M, Rafatpanah H, Abdoli Sereshki H, Zahedi MJ, Nikpoor AR, et al. Association of HLA-DRB1 Alleles with Ulcerative Colitis in the City of Kerman, South Eastern Iran. Iran J Allergy Asthma Immunol 2015;14:306–12
  15. Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, Huang H, et al. High-density mapping of the MHC identifie