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Journals / Türk Biyokimya Dergisi / 2020 / Cilt: 45 - Sayı: 5

Evaluation of thiol disulphide levels in patients with pulmonary embolism

Pulmoner Emboli Hastalarında Tiyol Disülfid Düzeylerinin Değerlendirilmesi

Özcan EREL
Ercan KURTİPEK
Said Sami ERDEM
Salim NEŞELİOĞLU
Taha Tahir BEKÇİ
Kamile YÜCEL
Pages
559–565
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Serum albumin levels in patients werestrongly correlated with plasma IMA (r=−0.737; p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Maintaining the thiol-disulphide balance isessential for antioxidant defense and apoptosis.
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Key Findings & Data:The studyaimed to evaluate of thiol-disulphide levels in patients withpulmonary embolism (PE).Methods: The study included a total of 97 participants: 48patients and 49 healthy individuals.
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Conclusion & Impact:Serum albumin levels in patients werestrongly correlated with plasma IMA (r=−0.737; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Maintaining the thiol-disulphide balance isessential for antioxidant defense and apoptosis. The studyaimed to evaluate of thiol-disulphide levels in patients withpulmonary embolism (PE).Methods: The study included a total of 97 participants: 48patients and 49 healthy individuals. Serum native thiol (NT),total thiol (TT) and disulphide (DS) levels (µmol/L) weremeasured using the novel spectrophotometric method.Results: We found significantly lower levels of NT(195.44±83.3 μmol/L), DS (20.42±9.20 μmol/L) and TT(236.26±90.66 μmol/L) in patients with PE compared withthe healthy controls (304.42±62.13, 24.33±8.09 and353.07±63.58 μmol/L respectively). Patients with PE hadlower serum albumin levels (3.11±1.03 g/dL) and higherischaemia modified albumin (IMA) levels (0.82±0.16 g/dL)compared with the controls (3.89±0.52 and 0.67±0.15 g/dL,respectively). Serum albumin levels in patients werestrongly correlated with plasma IMA (r=−0.737; p

Özet

Amaç: Antioksidan savunma ve apoptoz için tiyol-disülfid dengesini korumak şarttır. Bu çalışma pulmoner emboli (PE) hastalarında tiyol-disülfid düzeylerini değerlendir meyi amaçladı. Yöntem: Çalışmaya toplam 97 katılımcı dahil edildi: 48 hasta ve 49 sağlıklı birey. Serum native tiyol (NT), toplam tiyol (TT) ve disülfid (DS) seviyeleri (µmol/L) yeni spek trofotometrik yöntem kullanılarak ölçüldü. Bulgular: PE’li hastalarda sağlıklı kontrollere göre (sır asıyla, 304.42±62.13, 24.33±8.09 ve 353.07±63.58 μmol/L) anlamlı derecede daha düşük NT (195.44±83.3 μmol/L), DS (20.42±9.20 μmol/L) ve TT (236.26±90.66 μmol/L) seviyeleri bulduk. PE’li hastalarda kontrollere kıyasla (sırasıyla 3.89±0.52 ve 0.67±0.15 g/dL) serum albümin seviyeleri (3.11±1.03 g/dL) daha düşük ve iskemi mod ifiye albümin (IMA) seviyeleri (0.82±0.16 g/dL) daha yüksekti. Hastalardaki serum albümin seviyeleri, plazma IMA seviyeleri (r=−0.737; p

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Cite This Article

EREL, Ö., KURTİPEK, E., ERDEM, S. S., NEŞELİOĞLU, S., BEKÇİ, T. T., YÜCEL, K. (2022). Evaluation of thiol disulphide levels in patients with pulmonary embolism. Türk Biyokimya Dergisi, Cilt: 45 - Sayı: 5, 559–565. https://ajindex.com/articles/620771

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References (13)

  1. Morrone D, Morrone V. Acute pulmonary embolism: focus on the clinical picture. Korean Circ J 2018 Jul;48:661–3
  2. Noschang J, Guimarães MD, Teixeira DFD, Braga JCD, Horchhegger B. Pulmonary thromboembolism: new diagnostic imaging techniques. Radiol Bras 2018 May–Jun;51:178–86
  3. Brandt M, Giokoglu E, Garlapati V, Bochenek ML, Molitor M, Hobohm L, et al. Pulmonary arterial hypertension and endothelial dysfunction is linked to NADPH oksidase-derived superoxide formation in venous thrombosis and pulmonary embolism in mice. Oxid Med Cell Longev 2018 Jun 10;2018:1860513
  4. Waleed KB, Guan X, Li X, Yang Y, Wang Z, Yin X, et al. Atrial fibrilation is related to lower incidence of deep venous thrombosis in patients with pulmonary embolism. J Thorac Dis 2018 Mar;10:1476–82
  5. Raji H, JavadMoosavi SA, Dastoorpoor M, Mohamadipour Z, Ghanavati SPM. Overuse and underuse of pulmonary CT angiography in patients with suspected pulmonary embolism. Med J Islam Repub Iran 2018 Feb 4;32:3. PMID: 29977871
  6. Carpenter SL, Richardson T, Hall M. Increasing rate of pulmonary embolism diagnosed in hospitalized children in the United States from 2001 to 2014. Blood Adv 2018 Jun 26;2:1403–8
  7. Çoner A, Çiçek D, Balcıoğlu S, Akıncı S, Müderrisoğlu H. Successful treatment of massive pulmonary embolism with reteplase. Turk Kardiyol Dern Ars 2018 Mar;46:143–6
  8. Johnson A, Perlman MB, Blumenstock FA, Malik AB. Superoxide dismutase prevents the trombin induced increase in lung vascular permeabilitiy: role of superoxide in mediating the alterations in lung fluid balance. Circ Res 1986 Oct;59:405–15
  9. Go YM, Chandler JD, Jones DP. The cysteine proteome. Free Radic Biol Me. 2015 Jul;84:227–45
  10. Topuz M, Şen O, Kaplan M, Akkus O, Erel O, Gür M. The role of thiol/disulphide homeostasis in anthracycline associated cardiac toxicitiy. Int Heart J 2017 Feb 7;58:69–72
  11. Babaoglu E, Kilic H, Hezer H, Dag O, Parlak E, Sentürk A, et al. Comparison of thiol/disulphide homeostasis parameters in patiens with COPD, asthma and ACOS. Eur Rev Med Pharmacol Sci 2016 Apr;20:1537–43. 27160126
  12. Altıparmak IH, Erkuş ME, Sezen H, Demirbag R, Gunebakmaz O, Kaya Z, et al. The relation of serum thiol levels and thiol/ disulphide homeostasis with the severity of coronary artery disease. Kardiol Pol 2016;74:1346–53
  13. Omma A, Sandikci SC, Kücüksahin O, Alisik M, Erel O. Can the thiol/disulfide imbalance be a predictor of colchicine resistance in familiar mediterranean fever. J Korean Med Sci 2