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Journals / Türk Biyokimya Dergisi / 2020 / Cilt: 45 - Sayı: 5

Age, gender and season dependent25(OH)D levels in children and adults living inIstanbul

İstanbul’da yaşayan çocuk ve yetişkinlerde yaş, cinsiyet ve mevsime bağlı 25(OH)D Seviyeleri

Zeynep YILDIZ
Nihal YÜCEL
Asuman ORÇUN
Özlem ÇAKIR MADENCİ
Özlem HÜRMEYDAN
Pages
533–541
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This will provide large-scale data about 25(OH)D status in Turkish people and may contribute to the prevention and treatment of this condition for better healthcare outcomes.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: We evaluated population characteristics of serum 25-hydroxyvitamin D (25(OH)D) levels and determined the influence of age, gender and season in an extensive dataset.Materials and methods: Laboratory results of 103,509 adults and 19,186 children were retrospectively evaluated.
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Key Findings & Data:Study group was classified regarding ages as; 60 years for adults and 0–1, 1–12 months,1–3, 4–6, 7–9, 10–12, 13–15 and 16–18 years for children.
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Conclusion & Impact:This will provide large-scale data about 25(OH)D status in Turkish people and may contribute to the prevention and treatment of this condition for better healthcare outcomes.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: We evaluated population characteristics of serum 25-hydroxyvitamin D (25(OH)D) levels and determined the influence of age, gender and season in an extensive dataset.Materials and methods: Laboratory results of 103,509 adults and 19,186 children were retrospectively evaluated. Study group was classified regarding ages as; 60 years for adults and 0–1, 1–12 months,1–3, 4–6, 7–9, 10–12, 13–15 and 16–18 years for children. Seasonal values were also determined. Levels were measured by Architect i1000 SR (Abbott Diagnostics, USA).Results: The median (2.5–97.5 percentiles) of 25(OH)D levels were 38.75 (9.5–158.25) nmol/L for adults and 43.25 (11.25–125.5) nmol/L for children. There were significant gender differences for both adults and children. Values differed significantly among age subgroups (p’s < 0.01). A total of 63% of adults and 59.5% of children had 25(OH)D levels below 50 nmol/L (p < 0.001). 25(OH)D levels were significantly lower in the winter compared with summer (p’s < 0.001). Even levels in summer were moderate deficient for all group.Conclusion: The rate of 25(OH)D deficiency was remarkable during the whole year. This will provide large-scale data about 25(OH)D status in Turkish people and may contribute to the prevention and treatment of this condition for better healthcare outcomes.

Özet

Amaç: Serum 25-hidroksivitamin D (25(OH)D) seviyele rinin popülasyon özelliklerini ve yaş, cinsiyet ve mevsi min 25(OH)D düzeyleri üzerindeki etkisini geniş bir verisetinde değerlendirdik. Gereç ve Yöntem: 103,509 yetişkin ve 19,186 çocuğunlaboratuvar sonuçları retrospektif olarak değerlendirildi.Çalışma grubu yaşlara göre yetişkinler için; 60 ve çocuklar için 0–1 ay, 1–12 ay, 1–3, 4–6, 7–9,10–12, 13–15 ve 16–18 yaş olarak sınıflandırıldı. Mevsimseldeğerler de belirlendi. Serum 25(OH)D seviyeleri, Archi tect i1000SR (Abbott Diagnostics, ABD) tarafından kom petitif kemilüminesan (CIMA) metodu ile ölçüldü. Bulgular: 25(OH)D seviyelerinin yetişkinler ve çocuklariçin ortanca (2.5–97.5 yüzdelik) değerleri sırasıyla 38.75(9.5–158.25) ve 43.25 (11.25–125.5) nmol/L bulundu. Hemyetişkin hem de çocuklar arasında anlamlı düzeyde cin siyet farklılığı gözlendi. Yaş grupları arasında anlamlıfarklılık vardı (p < 0.01). Yetişkinlerin %63’ü, çocukların%59,5’i 50 nmol/L’nin altında 25(OH)D seviyesine sahipti(p < 0.001). 25(OH)D düzeyleri, yaza kıyasla kış mevsi minde anlamlı düzeyde düşük bulundu (p < 0.001). Tüm grupta yaz aylarında bile seviyeler orta düzeyde eksiklikgösterdi. Sonuç: 25(OH)D eksikliği tüm yıl boyunca dikkat çekicidüzeydeydi. Bu çalışma, İstanbul Anadolu Yakasındayaşayan popülasyonun 25(OH)D düzeyi hakkında genişçaplı veri sağlayacak ve bu durumun önlenmesi ve tedavi sine katkı sağlayacaktır.

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Cite This Article

YILDIZ, Z., YÜCEL, N., ORÇUN, A., MADENCİ, Ö. Ç., HÜRMEYDAN, Ö. (2022). Age, gender and season dependent25(OH)D levels in children and adults living inIstanbul. Türk Biyokimya Dergisi, Cilt: 45 - Sayı: 5, 533–541. https://ajindex.com/articles/620757

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