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Journals / Türk Biyokimya Dergisi / 2020 / Cilt: 45 - Sayı: 5

Relationship between renal tubulointerstitial fibrosis and serum prolidase enzyme activity

Renal tubülointerstisyal fibrozis ve serum prolidaz enzim aktivasyonu arasındaki ilişki

Hüseyin KAYADİBİ
İbrahim DOĞAN
Sümeyra KOYUNCU
Barış ESER
Nihal AYDEMİR
Erdal KOMUT
Aysel ÇOLAK
Hülya AKGÜN
Pages
567–573
Publication Date
2022-11-06
DOI
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SPEAwas measured by spectrophotometric method.Results: The proteinuria and SPEA levels of the patientswere significantly higher than the controls (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The severity of interstitial fibrosis/tubular atrophy (IFTA) is the most important determinant of theirreversible progression of chronic kidney disease (CKD).Prolidase is the key enzyme in collagen turnover and isassociated with an extracellular matrix increase.
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Key Findings & Data:We aimedto evaluate the relationship between the presence anddegree of IFTA and serum prolidase enzyme activity (SPEA)in patients undergoing a renal biopsy.Methods: This cross-sectional study included 56 patientswho underwent a renal biopsy (30 males; mean age45.3 ± 16.8 years) and also 54 healthy volunteers (21 males;mean age 42.7 ± 8.2 years).
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Conclusion & Impact:SPEAwas measured by spectrophotometric method.Results: The proteinuria and SPEA levels of the patientswere significantly higher than the controls (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: The severity of interstitial fibrosis/tubular atrophy (IFTA) is the most important determinant of theirreversible progression of chronic kidney disease (CKD).Prolidase is the key enzyme in collagen turnover and isassociated with an extracellular matrix increase. We aimedto evaluate the relationship between the presence anddegree of IFTA and serum prolidase enzyme activity (SPEA)in patients undergoing a renal biopsy.Methods: This cross-sectional study included 56 patientswho underwent a renal biopsy (30 males; mean age45.3 ± 16.8 years) and also 54 healthy volunteers (21 males;mean age 42.7 ± 8.2 years). IFTA scoring was performed onthe basis of percentage of IFTA presence in renal biopsytissues (1=50%). SPEAwas measured by spectrophotometric method.Results: The proteinuria and SPEA levels of the patientswere significantly higher than the controls (p

Özet

Giriş: İntersitisyal fibrozis/tubüler atrofi (IFTA) şiddeti kronik böbrek hastalığı (KBH)’nın geri dönüşümsüz ilerle mesinin en önemli belirleyicisidir. Prolidaz, kollajen döngüsünün kilit enzimidir ve ekstraselüler matriks artışı ile ilişkilidir. Çalışmamızda böbrek biyopsisi yapılan has talarda IFTA varlığı ve derecesi ile serum prolidaz enzim aktivitesi (SPEA) arasındaki ilişkinin değerlendirilmesi amaçlandı. Yöntem: Bu kesitsel çalışmaya böbrek biyopsisi yapılan 56 hasta (30 erkek; ortalam yaş 45.3 ± 16.8 yıl) ve 54 sağlıklı gönüllü (21 erkek; ortalama yaş 42.7 ± 8.2 yıl) dahil edildi. Renal biyopsi dokularında IFTA yaygınlık yüzdesi temelinde IFTA skorlaması yapıldı (1=50%). SPEA’i spektrofotometrik yöntem ile ölçüldü. Bulgular: Hastaların kontrollere göre proteinüri ve SPEA düzeyleri istatistiksel olarak anlamlı şekilde daha yüksekti (sırasıyla, p

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Cite This Article

KAYADİBİ, H., DOĞAN, İ., KOYUNCU, S., ESER, B., AYDEMİR, N., KOMUT, E., ÇOLAK, A., AKGÜN, H. (2022). Relationship between renal tubulointerstitial fibrosis and serum prolidase enzyme activity. Türk Biyokimya Dergisi, Cilt: 45 - Sayı: 5, 567–573. https://ajindex.com/articles/620752

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