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Journals / Türk Biyokimya Dergisi / 2020 / Cilt: 45 - Sayı: 1

Evaluating serum elastin levels in striaegravidarum

Stria gravidarumda serum elastin düzeylerinin değerlendirilmesi

Özgür ÖNAL
Sibel TUĞCUGİL
Ülkü METE URAL
Medeni ARPA
Beril GÜRLEK
Pages
76–82
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further controlled trials are warranted to determine the clinical significance of serum elastin levels in the formation of SG.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Striae gravidarum (SG) is the most common dermatological defect in pregnancy leading to cosmetic anxiety with unknown etiopathogenesis.
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Key Findings & Data:In total, 138 primipara pregnant women were examined before delivery.
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Conclusion & Impact:Further controlled trials are warranted to determine the clinical significance of serum elastin levels in the formation of SG.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Striae gravidarum (SG) is the most common dermatological defect in pregnancy leading to cosmetic anxiety with unknown etiopathogenesis. The aim of the study was to analyze the relation between serum elastin levels and striae and identify possible independent asso-ciated risk factors.Materials and methods: This was a prospective obser-vational study. In total, 138 primipara pregnant women were examined before delivery. Participants were sepa-rated into two groups according to the presence of SG. Striae assessment was performed according to Davey score. Before the active phase of labor patients were physically examined and blood samples were collected. Personal characteristics, features of birth, skin find-ings and serum elastin levels were compared between groups.Results: Term pregnant women with SG had signifi-cantly higher serum elastin levels than those without SG (99.46 ± 32.92 vs. 88.36 ± 19.12, respectively; p = 0.018).Conclusions: Serum elastin levels were increased in women with SG. However, the newly synthesized elas-tin may not be functional as it is thin and disorganized. Therefore, increased elastin production may not prevent the formation of striae. This finding may provide an impe-tus to explore the pathomechanisms of striae. Further controlled trials are warranted to determine the clinical significance of serum elastin levels in the formation of SG.

Özet

Amaç: Stria gravidarum, gebelikte kozmetik kaygıya yolaçan en yaygın dermatolojik sorunlardan biridir. Çalış- mamızın amacı, serum elastin düzeyleri ile stria gelişimiarasındaki ilişkiyi araştırmak ve stria gravidarumun oluşumunda rol alan risk faktörlerini belirlemektir. Gereç ve Yöntem: Prospektif olarak planlanan bu çalışma,doğum öncesi kliniğimize başvuran 138 primipar gebekatılımcı ile yapıldı. Katılımcılar, stria gravidarum varlı- ğına göre iki gruba ayrıldı. Stria değerlendirmesi Daveyskoruna göre yapıldı. Doğumun aktif fazından önce hasta- lara fizik muayene yapıldı ve kan örnekleri alındı. Gruplararasında klinik ve doğum özellikleri, cilt bulguları veserum elastin düzeyleri karşılaştırıldı. Bulgular: Stria gravidarumu olan gebe kadınlarda striagravidarumu olmayanlara göre serum elastin düzey- leri anlamlı derecede yüksekti (sırasıyla 99.46 ± 32.92 ve88.36 ± 19.12; p: 0.018). Sonuç: Stria gravidarumu olan gebe kadınlarda serumelastin düzeyleri artmaktadır. Bununla birlikte, yeni sen- tezlenen elastin ince ve dağınık yapıda olduğu için fonk- siyonel değildir. Bu nedenle, artan elastin üretimi, striaoluşumunu önlemede etkili olmayabilir. Bu sonuç gebe- likte stria patomekanizmasının anlaşılmasında önemlibir veri olsa da elastinin striae gravidarum gelişimindeki klinik önemini belirlemek için daha fazla çalışmaya ihtiyaç vardır.

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Cite This Article

ÖNAL, Ö., TUĞCUGİL, S., URAL, Ü. M., ARPA, M., GÜRLEK, B. (2022). Evaluating serum elastin levels in striaegravidarum. Türk Biyokimya Dergisi, Cilt: 45 - Sayı: 1, 76–82. https://ajindex.com/articles/620743

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