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Journals / Türk Biyokimya Dergisi / 2021 / Cilt: 46 - Sayı: 1

Investigation of miR-144-3p expression levels in HbSS cases with high and normal HbF

HbF’i normal ve yüksek olan HbSS’li olgularda miR-144-3p ekspresyon düzeylerinin araştırılması

Kıymet AKSOY
Zeliha Nazan ALPARSLAN
Gönül Şeyda SEYDEL
Figen GÜZELGÜL
Pages
53–58
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Statistical analysis was performed by the Mann-Whitney U test (SPSS 20.00 for Windows and p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background: Sickle cell anemia (HbSS) is a hereditary blood disease that affects millions of people worldwide.
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Key Findings & Data:Increased the HbF levels affects the clinical course of HbSS positively.
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Conclusion & Impact:Statistical analysis was performed by the Mann-Whitney U test (SPSS 20.00 for Windows and p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: Sickle cell anemia (HbSS) is a hereditary blood disease that affects millions of people worldwide. Increased the HbF levels affects the clinical course of HbSS positively. The aim of this study was to investigate the association between miR-144-3p and HbSS. Materials and methods: In this study 84 cases (44 HbSS/ HbS combination and 40 HbAA) were performed. The expression of miR-144-3p was determined by RT-PCR. Statistical analysis was performed by the Mann-Whitney U test (SPSS 20.00 for Windows and p

Özet

Amaç: Dünya’da milyonlarca insanı etkileyen orak hücreli anemi (Hb SS) bir kalıtsal kan hastalığıdır. Hb F düzeyinin yüksekliği Hb SS’in kliniğini pozitif yönde etkilemektedir. Bu çalışmadaki amacımız miR-144-3p ve HbSS’in birlikte liğini araştırmaktır. Gereç ve Yöntemler: Bu çalışmada 84 olgunun (44 HbSS/ HbS birlikteliği ve 40 HbAA) verileri değerlendirilmiştir. miR-144-3p’nin ekspresyonu RT-PCR ile belirlenmiştir. İstatistiksel analizler Mann-Whitney U testi (Windows SPSS 20.00 ve p

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Cite This Article

AKSOY, K., ALPARSLAN, Z. N., SEYDEL, G. Ş., GÜZELGÜL, F. (2022). Investigation of miR-144-3p expression levels in HbSS cases with high and normal HbF. Türk Biyokimya Dergisi, Cilt: 46 - Sayı: 1, 53–58. https://ajindex.com/articles/620728

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