Journals / Tüberküloz ve Toraks / 2019 / Cilt: 67 - Sayı: 3

Comparison of neutrophil to lymphocyte ratio with other prognostic markers affecting 30 day mortality in acute pulmonary embolism

Akut pulmoner embolide nötrofil lenfosit oranının 30 günlük mortaliteyi etkileyen diğer prognostik belirteçler ile karşılaştırılması

Pages
179–189
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

After the subgroup analysis of the study, in patients without comorbiddiseases NLR, patient’s risk status, sPESI score were found the predictor ofmortality in APE (p< 0.05).Conclusion: NLR maybe a useful prognostic factor for patients without comorbid diseases in short time of mortality in APE.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Identifying the prognostic factors for patients with acutepulmonary embolism (APE) play a critical role in determining of the treatmentstrategy and to reduce mortality.
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Key Findings & Data:The aim of this study is to evaluate theprognostic value of Neutrophil to Lymphocyte Ratio (NLR) and compare NLRwith other prognostic factors in APE.Materials and Methods: We retrospectively examined 550 cases of acutepulmonary embolism diagnosed by spiral computed tomographic angiography.A receiver operating characteristics (ROC) curve was used to determine thesensitivity and specificity of parameters and the optimal cut-off value forpredicting mortality.
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Conclusion & Impact:After the subgroup analysis of the study, in patients without comorbiddiseases NLR, patient’s risk status, sPESI score were found the predictor ofmortality in APE (p< 0.05).Conclusion: NLR maybe a useful prognostic factor for patients without comorbid diseases in short time of mortality in APE.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Identifying the prognostic factors for patients with acutepulmonary embolism (APE) play a critical role in determining of the treatmentstrategy and to reduce mortality. The aim of this study is to evaluate theprognostic value of Neutrophil to Lymphocyte Ratio (NLR) and compare NLRwith other prognostic factors in APE.Materials and Methods: We retrospectively examined 550 cases of acutepulmonary embolism diagnosed by spiral computed tomographic angiography.A receiver operating characteristics (ROC) curve was used to determine thesensitivity and specificity of parameters and the optimal cut-off value forpredicting mortality. Significance of each prognostic factors selected byunivariate analysis confirmed using Cox regression model.Results: Baseline NLR, Platelet to Lymphocyte Ratio (PLR), N-terminal proBrain Natriuretic Peptide (NT-proBNP), and D-dimer values respectively werefound significantly high in patients who died within 30 days (p 2 points had a significantly highershort-term mortality rate (p 7.3 (p 0.05). After the subgroup analysis of the study, in patients without comorbiddiseases NLR, patient’s risk status, sPESI score were found the predictor ofmortality in APE (p< 0.05).Conclusion: NLR maybe a useful prognostic factor for patients without comorbid diseases in short time of mortality in APE.

Özet

Giriş: Akut pulmoner emboli (APE)'de tedavi öncesinde prognostik faktörlerin bilinmesi tedavi stratejilerinin belirlenmesinde ve mortaliteyi azaltmada önemli bir rol oynamaktadır. Bu çalışmada APE'de Nötrofil Lenfosit Oranı (NLR)'nın prognostik değerinin incelenmesi ve diğer prognostik faktörler ile karşılaştırmak amaçlanmıştır. Materyal ve Metod: Spiral bilgisayarlı tomografi anjiyografi ile APE tanısı konulan 550 olgu retrospektif olarak değerlendirilmiştir. Parametrelerin duyarlılığını ve özgüllüğünü tespit etmek ve uygun kesme değerini belirlemek için ROC eğrisi kullanılmıştır. Tek değişkenli analiz ile belirlenmiş olan prognostik faktörlerin çok değişkenli sağkalım analizinde Cox regresyon analizi kullanıldı. Bulgular: İlk 30 gün içinde ölen olguların tanı anındaki NLR, Trombosit Lenfosit Oranı (PLR), N-terminal pro-Brain Natriüretik Peptid (NT-proBNP), D-Dimer değerleri anlamlı olarak daha yüksek saptandı (p 2 olan olguların kısa süreli mortalite oranları daha yüksek saptandı (p 7.3 olan olgularda anlamlı olarak daha yüksek bulunmuştur (p 0.05). Çalışmanın subgrup analizinde komorbiditesi olmayan APE hastalarında NLR, hastanın risk durumu ve sPESI kısa dönem mortalite için bağımsız risk faktörü olarak bulunmuştur (p< 0.05). Sonuç: Komorbiditesi olmayan APE olgularında NLR kısa süreli mortalite için yararlı bir prognostik faktör olabilir.

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Cite This Article

KASAPOĞLU, U. S., YILDIZELİ, Ş. O., CİMŞİT, N. Ç., ERYÜKSEL, E., KARAKURT, S., YALÇINKAYA, E., ERER, A., KABADAYI, F., ARIKAN, H., ASLAN, M. (2022). Comparison of neutrophil to lymphocyte ratio with other prognostic markers affecting 30 day mortality in acute pulmonary embolism. Tüberküloz ve Toraks, Cilt: 67 - Sayı: 3, 179–189. https://ajindex.com/articles/618391

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