AI Summary & Key Takeaways
AI InsightThe immune response to the vaccination was 92.7%, while the overall C. burnetiiseroprevalence in the flock after the human outbreak was 64.9%.
📌 3 Key Takeaways
Abstract
Following an outbreak of Q fever in a group of students who contracted the infection during a training course on a sheepfarm, a detailed investigation of the sheep flock involved was conducted. Of 478 flock animals, 60 Coxiella burnetii ELISA-positive and60 ELISA-negative ewes were selected for the trial and divided into four groups. A month after the initial ELISA screening, all ewesin the flock (except the control group) were vaccinated. Sequentially collected blood samples were tested with ELISA and PCR; feces,milk, manure, bedding, and soil were tested with PCR. The immune response to the vaccination was 92.7%, while the overall C. burnetiiseroprevalence in the flock after the human outbreak was 64.9%. PCR was positive for 0.2% of milk samples and 34.4% of fecal samplesof animals from all four trial groups. C. burnetii DNA was not detected in any of the blood samples. Manure was PCR-positive for about35 months; bedding from the stable was also positive while samples of pasture soil were negative. It appears that extensive cleaning anddisinfection combined with vaccination could be regarded as an appropriate approach to control/prevent Q fever in farm settings evenin the short term.