SavedAdd your journal

Journals / Turkish Journal of Veterinary and Animal Sciences / 2020 / Cilt: 44 - Sayı: 3

Investigation of the SCID mutant allele in Turkish Arabian horses reared in some private farms of the Eskişehir region in Turkey

Mustafa DOĞAN
Muhammet KAYA
Pages
729–733
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was determined that none of thehorses evaluated in this study carried the SCID mutant allele.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:There are several known hereditary diseases in Arabian horses.
📊
Key Findings & Data:A five-base deletion in the short arm (ECA9p12) of the equinechromosome 9, starting with codon 9480, which occurs in the catalytic subunit gene of the DNA-dependent protein kinase (DNAPKcs) results in severe combined immunodeficiency (SCID) hereditary disorder.
💡
Conclusion & Impact:It was determined that none of thehorses evaluated in this study carried the SCID mutant allele.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

There are several known hereditary diseases in Arabian horses. Many studies have been conducted on molecular diagnosticmethods of the mutations that cause these hereditary defects in horses. A five-base deletion in the short arm (ECA9p12) of the equinechromosome 9, starting with codon 9480, which occurs in the catalytic subunit gene of the DNA-dependent protein kinase (DNAPKcs) results in severe combined immunodeficiency (SCID) hereditary disorder. SCID is an autosomal recessive disorder whereinthe immune system of the affected foal is very weak. Purebred Turkish Arabian horses reared in the Eskişehir region have contributedgreatly to Turkish Arabian horse breeding and racing. The aim of this study was to detect the SCID mutant allele by using DNAsequencing analysis in Turkish Arabian horses, raised in nine different private farms in Eskişehir. It was determined that none of thehorses evaluated in this study carried the SCID mutant allele.

🔖

Cite This Article

DOĞAN, M., KAYA, M. (2022). Investigation of the SCID mutant allele in Turkish Arabian horses reared in some private farms of the Eskişehir region in Turkey. Turkish Journal of Veterinary and Animal Sciences, Cilt: 44 - Sayı: 3, 729–733. https://ajindex.com/articles/615132

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (11)

  1. AbouEl Ela NA, El-Nesr KA, Ahmed HA, Brooks SA. Molecular Detection of Severe Combined Immunodeficiency Disorder in Arabian Horses in Egypt. Journal of Equine Veterinary Science 2018
  2. doi: 10.1016/j.jevs.2018.05.210 2. Online Mendelian Inheritance in Animals (OMIA) (2019). Website https://omia.org/home/. [accessed 30.10.2019]. 3. Lund L. Equine severe combined immunodeficiency. SLU, Dept. of Animal Breeding and Genetics, Uppsala, 2007. 4. Perryman LE. Molecular Pathology of Severe Combined Immunodeficiency in Mice, Horses, and Dogs. Veterinary Pathology 2004
  3. 41(2): 95-100. doi: 10.1354/vp.41-2-95 5. Poppie MJ, McGuire TC. Combined immunodeficiency in foals in Arabian breeding: evaluation of mode of inheritance and estimation of prevalence of affected foals and carrier mares and stallions. Journal of the American Veterinary Medical Association 1977
  4. 170 (1): 31-33. 6. Shin EK, Perryman LE, Meek K. A kinase-negative mutation of DNA-PK (CS) in equine SCID results in defective coding and signal joint formation. The Journal of Immunology 1997
  5. 158 (8): 3565-3569. 7. Shin EK, Perryman LE, Meek K. Evaluation of a test for identification of Arabian horses heterozygous for the severe combined immunodeficiency trait. Journal of the American Veterinary Medical Association 1997
  6. 211 (10): 1268-1270. 8. Bernoco D, Bailey E. Frequency of the SCID gene among Arabian horse in USA. Animal Genetics 1998
  7. doi: 10.1046/j.1365-2052.1998.00237.x 9. Swinburne J, Lockhart L, Scott M, Binns MM. Estimation of the Prevalence of Severe Combined Immuno deficiency Disease in UK Arab Horses as Determined by a DNA-based test. Veterinary Record 1999
  8. doi: 10.1136/vr.145.1.22 10. Teixeira CS, Oliveira DAA, Kuabara MY. Prevalência da imunodeficiência severa combinada em cavalos da raça Árabe em plantéis de Minas Gerais e São Paulo (in Portuguese). Arquivo Brasileiro de Medicina Veterinária e Zootecnia 2001
  9. 53 (3): 380-384. doi: 10.1590/s0102-09352001000300018 11. Piro M, Benjouad A, Tligui NS, Allali KE, Kohen ME et al. Frequency of the severe combined immunodeficiency disease gene among horses in Morocco. Equine Veterinary Journal 2008
  10. 40 (6): 590-591. doi: 10.2746/042516408X333001 12. Tarr CJ, Thompson PN, Guthrie AJ, Harper CK. The carrier prevalence of severe combined immunodeficiency, lavender foal syndrome and cerebellar abiotrophy in Arabian horses in South Africa. Equine Veterinary Journal 2014
  11. doi: 10.1111/evj.12177 13. Kurylenk