Journals / Turkish Journal of Surgery / 2020 / Cilt: 36 - Sayı: 1

Evaluation of the efficacy of platelet-rich plasma in preventing postoperative intraabdominal adhesions

Postoperatif intraabdominal adezyonları önlemede trombositten zengin plazmanın etkinliğinin değerlendirilmesi

Pages
53–58
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

However, mean scores for inflammatory cell infiltration and angiogenesis were higher in Group 2 and the differences were statistically significant (p= 0.021).Conclusion: We were not able to report the positive results of PRP; however, we believe that we shed an important light for future studies which mightbe conducted using the combination of different methods.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Postoperative intraabdominal adhesions still maintain their currency as serious causes of morbidity and mortality.
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Key Findings & Data:This study aimed at evaluating the role of platelet-rich plasma (PRP) in the prevention of intraabdominal adhesions.Material and Methods: A total of 16 healthy rabbits were used within the scope of the study.
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Conclusion & Impact:However, mean scores for inflammatory cell infiltration and angiogenesis were higher in Group 2 and the differences were statistically significant (p= 0.021).Conclusion: We were not able to report the positive results of PRP; however, we believe that we shed an important light for future studies which mightbe conducted using the combination of different methods.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Postoperative intraabdominal adhesions still maintain their currency as serious causes of morbidity and mortality. This study aimed at evaluating the role of platelet-rich plasma (PRP) in the prevention of intraabdominal adhesions.Material and Methods: A total of 16 healthy rabbits were used within the scope of the study. The animals were allocated into two groups as Group1 (control group) and Group 2 (study group). In all subjects, cecal abrasion was formed by laparotomy. In the study group, platelet rich plasma wasadministered intraabdominally. At the end of the study, the adhesions were evaluated by Nair’s Score.Results: Total adhesion score in Group 1 was 8, while the mean score was 1. On the other hand, total adhesion score in Group 2 was 12, while the meanscore was 1.5. There was no statistical difference between both groups by total adhesion score and mean fibrosis score. However, mean scores for inflammatory cell infiltration and angiogenesis were higher in Group 2 and the differences were statistically significant (p= 0.021).Conclusion: We were not able to report the positive results of PRP; however, we believe that we shed an important light for future studies which mightbe conducted using the combination of different methods.

Özet

Giriş ve Amaç: Postoperatif intraabdominal adezyonlar, günümüzde hala ciddi morbidite ve mortalite nedenidir. Bu çalışmada, trombositten zengin plazma (PRP)’nın intraabdominal adezyonların önlenmesindeki rolünün değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Çalışma kapsamında toplam 16 sağlıklı tavşan kullanıldı. Hayvanlar, Grup 1 (kontrol grubu) ve Grup 2 (çalışma grubu) olarak iki gruba ayrıldı. Tüm deneklerde laparotomi ile çekal abrazyon oluşturuldu. Çalışma grubunda PRP intraabdominal olarak uygulandı. Çalışmanın sonunda adezyonlar Nair’s Skoru ile değerlendirildi. Bulgular: Grup 1’deki toplam adezyon skoru 8 iken, ortalama skor 1 idi. Öte yandan, Grup 2’deki toplam adezyon skoru 12 iken, ortalama skor 1,5 idi. Her iki grup arasında toplam adezyon skoru ve ortalama fibroz skoru açısından istatistiksel olarak bir fark yoktu. Ancak, enflamatuvar hücre enfiltrasyonu ve anjiyogenez skorları Grup 2’de istatistiksel olarak daha yüksekti (p= 0,021). Sonuç: PRP’nin postoperatif intraabdominal adezyonları önlemesine dair olumlu sonuçları bulamadık. Ancak, farklı yöntemlerin kombinasyonu kullanılarak yapılabilecek gelecekteki çalışmalar için bu çalışmanın önemli bir ışık tutacağına inanıyoruz.

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Cite This Article

KARGIN, S., TURAN, E., AYHAN, B., DOĞRU, O., UĞRAŞ, N. S. (2022). Evaluation of the efficacy of platelet-rich plasma in preventing postoperative intraabdominal adhesions. Turkish Journal of Surgery, Cilt: 36 - Sayı: 1, 53–58. https://ajindex.com/articles/614285

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