Objectives: To determine the secondary metabolites from Verbascum mucronatum Lam. and evaluate their antimicrobial activity.Materials and Methods: Antimicrobial activities of the isolated metabolites were determined using broth microdilutions against the bacteria(Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 29213) andfungi (Candida albicans ATCC 90028, Candida krusei ATCC 6258, Candida parapsilosis ATCC 90018).Results: Four iridoid glycosides; ajugol (1), aucubin (2), lasianthoside I (3), catalpol (4), two triterpenic saponins; ilwensisaponin C (5), ilwensisaponinA (=mimengoside A) (6), and one phenylethanoid glycoside; verbascoside (=acteoside) (7) were isolated from the water soluble parts of themethanolic extract gained flowery parts of V. mucronatum Lam.Conclusion: Within the obtained compounds, ajugol and ilwensisaponin A showed moderate antimicrobial activity, especially against fungi
📌 3 Key Takeaways
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Objective & Hypothesis:Objectives: To determine the secondary metabolites from Verbascum mucronatum Lam. and evaluate their antimicrobial activity.Materials and Methods: Antimicrobial activities of the isolated metabolites were determined using broth microdilutions against the bacteria(Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 29213) andfungi (Candida albicans ATCC 90028, Candida krusei ATCC 6258, Candida parapsilosis ATCC 90018).Results: Four iridoid glycosides; ajugol (1), aucubin (2), lasianthoside I (3), catalpol (4), two triterpenic saponins; ilwensisaponin C (5), ilwensisaponinA (=mimengoside A) (6), and one phenylethanoid glycoside; verbascoside (=acteoside) (7) were isolated from the water soluble parts of themethanolic extract gained flowery parts of V. mucronatum Lam.Conclusion: Within the obtained compounds, ajugol and ilwensisaponin A showed moderate antimicrobial activity, especially against fungi
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Key Findings & Data:Objectives: To determine the secondary metabolites from Verbascum mucronatum Lam. and evaluate their antimicrobial activity.Materials and Methods: Antimicrobial activities of the isolated metabolites were determined using broth microdilutions against the bacteria(Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 29213) andfungi (Candida albicans ATCC 90028, Candida krusei ATCC 6258, Candida parapsilosis ATCC 90018).Results: Four iridoid glycosides; ajugol (1), aucubin (2), lasianthoside I (3), catalpol (4), two triterpenic saponins; ilwensisaponin C (5), ilwensisaponinA (=mimengoside A) (6), and one phenylethanoid glycoside; verbascoside (=acteoside) (7) were isolated from the water soluble parts of themethanolic extract gained flowery parts of V. mucronatum Lam.Conclusion: Within the obtained compounds, ajugol and ilwensisaponin A showed moderate antimicrobial activity, especially against fungi
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Conclusion & Impact:Objectives: To determine the secondary metabolites from Verbascum mucronatum Lam. and evaluate their antimicrobial activity.Materials and Methods: Antimicrobial activities of the isolated metabolites were determined using broth microdilutions against the bacteria(Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 29213) andfungi (Candida albicans ATCC 90028, Candida krusei ATCC 6258, Candida parapsilosis ATCC 90018).Results: Four iridoid glycosides; ajugol (1), aucubin (2), lasianthoside I (3), catalpol (4), two triterpenic saponins; ilwensisaponin C (5), ilwensisaponinA (=mimengoside A) (6), and one phenylethanoid glycoside; verbascoside (=acteoside) (7) were isolated from the water soluble parts of themethanolic extract gained flowery parts of V. mucronatum Lam.Conclusion: Within the obtained compounds, ajugol and ilwensisaponin A showed moderate antimicrobial activity, especially against fungi
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Objectives: To determine the secondary metabolites from Verbascum mucronatum Lam. and evaluate their antimicrobial activity.Materials and Methods: Antimicrobial activities of the isolated metabolites were determined using broth microdilutions against the bacteria(Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 29213) andfungi (Candida albicans ATCC 90028, Candida krusei ATCC 6258, Candida parapsilosis ATCC 90018).Results: Four iridoid glycosides; ajugol (1), aucubin (2), lasianthoside I (3), catalpol (4), two triterpenic saponins; ilwensisaponin C (5), ilwensisaponinA (=mimengoside A) (6), and one phenylethanoid glycoside; verbascoside (=acteoside) (7) were isolated from the water soluble parts of themethanolic extract gained flowery parts of V. mucronatum Lam.Conclusion: Within the obtained compounds, ajugol and ilwensisaponin A showed moderate antimicrobial activity, especially against fungi
Özet
Amaç: Bu çalışmada Verbascum mucronatum Lam.’ın sekonder metabolitlerinin belirlenmesi ve antimikrobiyal aktivitelerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: İzole edilen metabolitlerin, bakteri (Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 29213) ve mantarlara (Candida albicans ATCC 90028, Candida krusei ATCC 6258, Candida parapsilosis ATCC 90018) karşı antimikrobiyal aktiviteleri sıvı mikrodilüsyon yöntemiyle belirlenmiştir. Bulgular: V. mucronatum Lam.’ın çiçekli kısımlarının metanol ektresinin suda çözünen kısımlarından, dört iridoit glikoziti, ajugol (1), okubin (2), lasiantozit I (3), katalpol (4); iki triterpenik saponin, ilvensisaponin C (5), ilvensisaponin A (=mimengozit A) (6) ve bir feniletanoit glikoziti, verbaskozit (=akteozit) (7) izole edilmiştir. Sonuç: Elde edilen bileşikler içinde ajugol ve ilvensisaponin A, özellikle mantarlara karşı zayıf antimikrobiyal aktivite göstermiştir
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Cite This Article
KART, D., AYDEMİR, Z. Ş., TATLI, İ. İ., KAHRAMAN, Ç., EKİZOĞLU, M. (2022). Structure Elucidation and Antimicrobial Activities of Secondary Metabolites from the Flowery Parts of Verbascum mucronatum Lam. Turkish Journal of Pharmaceutical Sciences, Cilt: 15 - Sayı: 3, 231–237. https://ajindex.com/articles/613858
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