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Journals / Turkish Journal of Pharmaceutical Sciences / 2018 / Cilt: 15 - Sayı: 2

Phytochemical Analysis and Antidepressant Activity of Ixora coccinea Extracts in Experimental Models of Depression in Mice

Ixora coccinea Ekstrelerinin Fitokimyasal Analizi ve Sıçanlarda Depresyon Deney Modeli Üzerindeki Antidepresan Aktivitesi

Ajaykumar Rikhabchand SURANA
Rajendra Dayaram WAGH
Pages
130–135
Publication Date
2022-11-05
DOI
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GC-MS analysis of methanol extract of I. coccinea was performed to ascertain the chemicalconstituents in the bioactive extract.Results: The methanol extract of I. coccinea at dose of 100 and 200 mg/kg body weight, p.o. significantly reduced the total duration of immobility inthe TST as well as FST (p

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Objective & Hypothesis:Objectives: The present study aims to assess the antidepressant activity of Ixora coccinea extracts in mice and phytochemical analysis of the activeextract by GC-MS.Materials and Methods: After oral administration of extracts, tail suspension test (TST), force swim tests (FST), and open field tests (OFT) wereperformed to assess the antidepressant activity.
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Key Findings & Data:Objectives: The present study aims to assess the antidepressant activity of Ixora coccinea extracts in mice and phytochemical analysis of the activeextract by GC-MS.Materials and Methods: After oral administration of extracts, tail suspension test (TST), force swim tests (FST), and open field tests (OFT) wereperformed to assess the antidepressant activity.
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Conclusion & Impact:GC-MS analysis of methanol extract of I. coccinea was performed to ascertain the chemicalconstituents in the bioactive extract.Results: The methanol extract of I. coccinea at dose of 100 and 200 mg/kg body weight, p.o. significantly reduced the total duration of immobility inthe TST as well as FST (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: The present study aims to assess the antidepressant activity of Ixora coccinea extracts in mice and phytochemical analysis of the activeextract by GC-MS.Materials and Methods: After oral administration of extracts, tail suspension test (TST), force swim tests (FST), and open field tests (OFT) wereperformed to assess the antidepressant activity. GC-MS analysis of methanol extract of I. coccinea was performed to ascertain the chemicalconstituents in the bioactive extract.Results: The methanol extract of I. coccinea at dose of 100 and 200 mg/kg body weight, p.o. significantly reduced the total duration of immobility inthe TST as well as FST (p

Özet

Amaç: Bu çalışmada, Ixora coccinea ekstrelerinin sıçanlardaki antidepresan etkisi araştırılmış ve GC-MS tekniği kullanılarak aktif ekstrenin fitokimyasal analizi yapılmıştır. Gereç ve Yöntemler: Ekstrelerin oral yolla uygulanmasının ardından, antidepresan etkinin değerlendirilmesi için kuyruktan asma testi (KAT), zorunlu yüzme testi (ZYT) ve açık alan testi (AAT) kullanılmıştır. Biyoaktif ekstredeki fitokimyasal bileşenleri aydınlatmak amacıyla I. coccinea metanollü ekstresi üzerinde GC-MS analizi yapılmıştır. Bulgular: I. coccinea metanollü ekstresi 100 ve 200 mg/kg dozda, oral yolla uygulandığında, KAT ve ZYT testlerinde toplam hareketsizlik süresini anlamlı bir şekilde azaltmıştır (p

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Cite This Article

SURANA, A. R., WAGH, R. D. (2022). Phytochemical Analysis and Antidepressant Activity of Ixora coccinea Extracts in Experimental Models of Depression in Mice. Turkish Journal of Pharmaceutical Sciences, Cilt: 15 - Sayı: 2, 130–135. https://ajindex.com/articles/613852

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