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Journals / Türk Biyokimya Dergisi / 2009 / Cilt: 34 - Sayı: 4

Genç türk popülasyonunda koroner arter hastalığı risk faktörü olarak PON192 polimorfizmi ve LDL-oksidasyonu

PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population

Bilal İLANBEY
Yasemin D. AKÇAY
Eser Y. SÖZMEN
Ebru SEZER
Meral KAYIKÇIOĞLU
Hakan KÜLTÜRSAY
Pages
250–255
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Total cholesterol, triglyceride, basal-LDL-diene and stimulatedLDL-TBARSlevels were higher, paraoxonase and arylesterase activities were lower in patients withcoronary artery disease compared to controls(p

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: There are conflicting reports on paraoxonase1 (PON1) polymorphism as arisk factor for cardiovascular disease.
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Key Findings & Data:It’s been proposed that there is relationship between coronary artery disease and PON1-55L or PON1-192R alleles.
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Conclusion & Impact:Results: Total cholesterol, triglyceride, basal-LDL-diene and stimulatedLDL-TBARSlevels were higher, paraoxonase and arylesterase activities were lower in patients withcoronary artery disease compared to controls(p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: There are conflicting reports on paraoxonase1 (PON1) polymorphism as arisk factor for cardiovascular disease. It’s been proposed that there is relationship between coronary artery disease and PON1-55L or PON1-192R alleles. Nevertheless recentpublications showed major differences of PON1 activity and concentration in differentpopulations. We aimed to study low-density-lipoprotein (LDL) oxidation and PON1 activities (paraoxonase/arylesterase) regarding to PON192 polymorphism, in order to determine if they might be useful markers especially for young patients with coronary artery disease in Turkish population. Methods: 60 patients (38.1±5.0 years) with coronary artery disease and 52 healthy control subjects (32.5±6.1 years) were taken into study. Paraoxonase192 polymorphism, paraoxonase activity and oxidation status of all patients were analyzed. Results: Total cholesterol, triglyceride, basal-LDL-diene and stimulatedLDL-TBARSlevels were higher, paraoxonase and arylesterase activities were lower in patients withcoronary artery disease compared to controls(p

Özet

Amaç: Kardiyovasküler hastalık risk faktörü olarak paraoksonaz1 (PON1) polimorfizminin rolüyle ilgili çok sayıda çelişkili rapor bulunmaktadır. Koroner arter hastalığı ilePON1-55L ya da PON1-192R alelleri arasında ilişki olduğu öne sürülmüştür. Diğer yandan son yayınlarda farklı popülasyonların PON1 aktivitesi ve konsantrasyonları arasında büyük farklılıklar olduğu gösterilmiştir. Bu çalışmada PON192 polimorfizmine göredüşük-dansiteli-lipoprotein (LDL) oksidasyon belirteçleri ve PON1 aktivitelerinin (paraoksonaz ve aril esteraz) özellikle Türk popülasyonunda koroner arter hastalığı bulunan gençlerde bu hastalık açısından yararlı belirteçler olup olmadıklarının araştırılması amaçlandı. Gereç ve Yöntem: Koroner arter hastalığı olan 60 hasta (38.1±5.0 yaşında) ve 52 sağlıklı kontrol (32.5±6.1 yaşında) çalışmaya alındı. Tüm hastalarda PON192 polimorfizmi, paraoksonaz aktivitesi, serum oksidasyon düzeyi belirlendi.Bulgular: Koroner arter hastalarında total kolesterol, trigliserid, bazal-dien ve stimüle-LDL tiobarbitürik asidle reaksiyon veren yapıların (TBARS) düzeyleri kontrolleregöre yüksek bulunurken PON1 ve arilesteraz aktivitelerinin düşük olduğu tespit edildi (p

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Cite This Article

İLANBEY, B., AKÇAY, Y. D., SÖZMEN, E. Y., SEZER, E., KAYIKÇIOĞLU, M., KÜLTÜRSAY, H. (2022). Genç türk popülasyonunda koroner arter hastalığı risk faktörü olarak PON192 polimorfizmi ve LDL-oksidasyonu. Türk Biyokimya Dergisi, Cilt: 34 - Sayı: 4, 250–255. https://ajindex.com/articles/613831

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