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Journals / Turkish Journal of Pharmaceutical Sciences / 2019 / Cilt: 16 - Sayı: 2

Identification, Quantification, and Antioxidant Activity of Hydroalcoholic Extract of Artemisia campestris from Algeria

Cezayir’de Yetişen Artemisia campestris’in Sulu Alkollü Ekstresinin Tanımlanması, Kantitasyonu ve Antioksidan Aktivitesi

Boulanouar BAKCHICHE
Abdelaziz GHERIB
Maria Rosário BRONZE
Mosad A. GHAREEB
Pages
234–239
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Additionally, the hydroalcoholic extract exhibited a promising antioxidant activity value of 120.5±10.4 μmol Troloxequivalent antioxidant capacity/g dry weight (DW), and a strong correlation exists between this activity and the total phenolic content value of102.09±1.65 mg/g gallic acid equivalents DW.Conclusion: The hydroalcoholic extract of A. campestris is a promising candidate for the production of naturally occurring antioxidant agents.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Our study aimed to investigate the chemical profile of hydroalcoholic extract of Algerian Artemisia campestris and its antioxidant activity.Materials and Methods: The hydroalcoholic extract of Algerian A. campestris was investigated for its phenolic constituents using high performanceliquid chromatography (HPLC)-diode array detection (DAD)-electrospray ionization (ESI)-mass spectrometer (MS)/MS.
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Key Findings & Data:The in vitro antioxidantactivity and total phenolic content were also evaluated via oxygen radical absorbance capacity and Folin–Ciocalteu assays, respectively.Results: HPLC-DAD-ESI-MS/MS analysis revealed that the main tentatively identified compounds were caffeoylquinic acid isomers, flavonoids,and benzoic acid derivatives.
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Conclusion & Impact:Additionally, the hydroalcoholic extract exhibited a promising antioxidant activity value of 120.5±10.4 μmol Troloxequivalent antioxidant capacity/g dry weight (DW), and a strong correlation exists between this activity and the total phenolic content value of102.09±1.65 mg/g gallic acid equivalents DW.Conclusion: The hydroalcoholic extract of A. campestris is a promising candidate for the production of naturally occurring antioxidant agents.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Our study aimed to investigate the chemical profile of hydroalcoholic extract of Algerian Artemisia campestris and its antioxidant activity.Materials and Methods: The hydroalcoholic extract of Algerian A. campestris was investigated for its phenolic constituents using high performanceliquid chromatography (HPLC)-diode array detection (DAD)-electrospray ionization (ESI)-mass spectrometer (MS)/MS. The in vitro antioxidantactivity and total phenolic content were also evaluated via oxygen radical absorbance capacity and Folin–Ciocalteu assays, respectively.Results: HPLC-DAD-ESI-MS/MS analysis revealed that the main tentatively identified compounds were caffeoylquinic acid isomers, flavonoids,and benzoic acid derivatives. Additionally, the hydroalcoholic extract exhibited a promising antioxidant activity value of 120.5±10.4 μmol Troloxequivalent antioxidant capacity/g dry weight (DW), and a strong correlation exists between this activity and the total phenolic content value of102.09±1.65 mg/g gallic acid equivalents DW.Conclusion: The hydroalcoholic extract of A. campestris is a promising candidate for the production of naturally occurring antioxidant agents.

Özet

Amaç: Bu çalışmada, Cezayir’de yetişen Artemisia campestris’in sulu alkollü ekstresinin kimyasal profilinin ve antioksidan etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Cezayir’de yetişen A. campestris’in sulu alkollü ekstresinin fenolik bileşenleri yüksek performanslı sıvı kromatografisi (HPLC) diyot dizinli dedektör-(DAD)-elektrosprey iyonizasyonu (ESI)-mass spektrometresi (MS)/MS kullanılarak incelenmiştir. İn vitro antioksidan aktivite ve toplam fenolik içerik de sırasıyla oksijen radikal absorbans kapasitesi ve Folin-Ciocalteu analizleri ile değerlendirilmiştir. Bulgular: HPLC-DAD-ESI-MS/MS analizi, esas olarak saptanan ana bileşiklerin, kafeoilkuinik asit izomerleri, flavonoitler ve benzoik asit türevleri olduğunu ortaya koymuştur. Bununla birlikte, sulu alkollü ekstre 120.5±10.4 μmol Trolox eşdeğeri antioksidan kapasitesi/g kuru ağırlık (KA) değeri ile önemli derecede antioksidan aktivite göstermiş ve bu aktivite ile 102.09±1.65 mg/g gallik asit eş değeri KA olduğu belirlenen toplam fenolik içerik değeri arasında güçlü bir korelasyon saptanmıştır. Sonuç: Sonuç olarak, A. campestris’in sulu alkollü ekstresinin, doğal antioksidan ajanların üretimi için umut verici bir aday olduğu belirtilmiştir.

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Cite This Article

BAKCHICHE, B., GHERIB, A., BRONZE, M. R., GHAREEB, M. A. (2022). Identification, Quantification, and Antioxidant Activity of Hydroalcoholic Extract of Artemisia campestris from Algeria. Turkish Journal of Pharmaceutical Sciences, Cilt: 16 - Sayı: 2, 234–239. https://ajindex.com/articles/613803

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