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Journals / Turkish Journal of Pharmaceutical Sciences / 2019 / Cilt: 16 - Sayı: 1

Enhancement of Dissolution of Fenofibrate Using Complexation with Hydroxy Propyl β-Cyclodextrin

Hidroksi Propil β-Siklodekstrin ile Kompleksasyon Kullanılarak Fenofibratın Çözünmesinin Arttırılması

Sachin K. JAGDALE
Mohammad H. DEHGHAN
Nilesh S. PAUL
Pages
48–53
Publication Date
2022-11-05
DOI
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DSCstudies indicated a loss in crystalline state of fenofibrate in complexes.Conclusion: Complexation with HPβCD can be used as a useful tool for the enhancement of dissolution of fenofibrate.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The aim of the present study was to enhance the dissolution rate of fenofibrate using complexation with hydroxy propyl β-cyclodextrin(HPβCD).Materials and Methods: The phase solubility behavior of fenofibrate was studied in various concentrations of (HPβCD) aq. solution at 37°C.
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Key Findings & Data:Thesolubility of fenofibrate increased with an increase in the amount of HPβCD aq. solution.
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Conclusion & Impact:DSCstudies indicated a loss in crystalline state of fenofibrate in complexes.Conclusion: Complexation with HPβCD can be used as a useful tool for the enhancement of dissolution of fenofibrate.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: The aim of the present study was to enhance the dissolution rate of fenofibrate using complexation with hydroxy propyl β-cyclodextrin(HPβCD).Materials and Methods: The phase solubility behavior of fenofibrate was studied in various concentrations of (HPβCD) aq. solution at 37°C. Thesolubility of fenofibrate increased with an increase in the amount of HPβCD aq. solution. Gibbs free energy (ΔG°)tr values were all negative.Complexes of fenofibrate with HPβCD were prepared in 1:1 ratio by kneading and coprecipitation. These complexes were evaluated by dissolutionstudies, fourier transform infrared (FTIR) spectroscopy, and differential scanning calorimetry (DSC) studies.Results: The complexation of fenofibrate with HPβCD exhibited an enhanced dissolution rate. The mean dissolution time of fenofibrate decreasedsignificantly upon complexation. FTIR studies showed the formation of intermolecular hydrogen bonding between fenofibrate and HPβCD. DSCstudies indicated a loss in crystalline state of fenofibrate in complexes.Conclusion: Complexation with HPβCD can be used as a useful tool for the enhancement of dissolution of fenofibrate.

Özet

Amaç: Bu çalışmanın amacı, hidroksi propil β-siklodekstrin (HPβCD) ile kompleksasyon kullanarak fenofibratın çözünme hızını arttırmaktı. Gereç ve Yöntemler: Fenofibratın faz çözünürlük davranışları (HPβCD) çeşitli konsantrasyonlardaki sulu çözeltisinde, 37°C’de çalışıldı. Fenofibratın çözünürlüğü, artan miktarda HPβCD’nin sulu çözeltisi ile arttı. Gibbs serbest enerji (ΔG°)tr değerlerinin hepsi negatifti. HPβCD ile fenofibrat kompleksleri, 1:1 oranında yoğurma ve kopresipitasyon ile hazırlandı. Bu kompleksler, çözünme çalışmaları, fourier dönüşümü kızılötesi spektroskopisi (FTIR) ve diferansiyel tarama kalorimetrisi (DSC) çalışmaları ile değerlendirildi. Bulgular: Fenofibratın HPβCD ile kompleksasyonu, gelişmiş bir çözünme hızı sergiledi. Fenofibratın ortalama çözünme süresi, kompleksasyon üzerine önemli ölçüde azaldı. FTIR çalışmaları fenofibrat ve HPβCD arasında moleküller arası hidrojen bağlanmasının oluşumunu göstermiştir. DSC çalışmaları komplekslerde kristalin fenofibrat durumunda bir kayıp olduğunu gösterdi. Sonuç: HPβCD ile kompleksasyon, fenofibratın çözünmesinin arttırılması için yararlı bir araç olarak kullanılabilir.

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Cite This Article

JAGDALE, S. K., DEHGHAN, M. H., PAUL, N. S. (2022). Enhancement of Dissolution of Fenofibrate Using Complexation with Hydroxy Propyl β-Cyclodextrin. Turkish Journal of Pharmaceutical Sciences, Cilt: 16 - Sayı: 1, 48–53. https://ajindex.com/articles/613802

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