Journals / Turkish Journal of Pharmaceutical Sciences / 2019 / Cilt: 16 - Sayı: 1

Subchronic Toxicity Assessment of Orally Administered Methanol (70%) Seed Extract of Abrus precatorius L. in Wistar Albino Rats

Wistar Albino Sıçanlarda Oral Olarak Uygulanmış Abrus precatorius L. Tohum Metanol (%70) Ekstraktının Subkronik Toksisite Değerlendirmesi

Pages
88–95
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

ANOVA followed by the Bonferroni test was used for datainterpretation and p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Abrus precatorius L. is a famous medicinal plant of the family Fabaceae and is widely used in traditional medicine for the treatment ofvarious ailments.
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Key Findings & Data:However, there are limited toxicological data available regarding its safety following repeated exposure; therefore, the presentstudy was designed to evaluate the 28-day subchronic toxicity of methanol (70%) crude extract of A. precatorius seeds in adult Wistar albino rats.Materials and Methods: A subchronic toxicity experiment was conducted by oral administration of graded doses (200 mg/kg and 400 mg/kg) oftest extract daily for 28 days.
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Conclusion & Impact:ANOVA followed by the Bonferroni test was used for datainterpretation and p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Abrus precatorius L. is a famous medicinal plant of the family Fabaceae and is widely used in traditional medicine for the treatment ofvarious ailments. However, there are limited toxicological data available regarding its safety following repeated exposure; therefore, the presentstudy was designed to evaluate the 28-day subchronic toxicity of methanol (70%) crude extract of A. precatorius seeds in adult Wistar albino rats.Materials and Methods: A subchronic toxicity experiment was conducted by oral administration of graded doses (200 mg/kg and 400 mg/kg) oftest extract daily for 28 days. Signs of toxicity, food and water consumption, body weight, and gross pathology as well as relative organ weightwere evaluated. The toxic effects were also assessed using hematological and biochemical data followed by histopathological examination ofvarious internal organs. All data collected were expressed as mean ± standard deviation. ANOVA followed by the Bonferroni test was used for datainterpretation and p

Özet

Amaç: Abrus precatorius L., Fabaceae familyasından ünlü bir şifalı bitkidir ve geleneksel tıpta çeşitli rahatsızlıkların tedavisinde yaygın olarak kullanılır. Bununla birlikte, tekrarlanan maruz kalmanın ardından güvenliği ile ilgili sınırlı toksikolojik veriler mevcuttur; bu nedenle, bu çalışma yetişkin Wistar albino sıçanlarında A. precatorius tohumlarının metanol (%70) ham ekstraktının 28 günlük subkronik toksisitesini değerlendirmek üzere tasarlanmıştır. Gereç ve Yöntemler: Yirmi sekiz gün boyunca, günlük olarak test edilen dozlar (200 mg/kg ve 400 mg/kg) oral yolla uygulanarak bir subkronik toksisite deneyi gerçekleştirildi. Toksisite belirtileri, yiyecek ve su tüketimi, vücut ağırlığı ve makroskopik patolojinin yanı sıra nispi organ ağırlığı değerlendirildi. Toksik etkiler, hematolojik ve biyokimyasal veriler kullanılarak değerlendirildi ve bunu takiben çeşitli iç organların histopatolojik incelemesi yapıldı. Toplanan tüm veriler ortalama ± standart sapma olarak ifade edildi. Verilerin yorumlanması için ANOVA ve ardından Bonferroni testi kullanıldı ve p

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Cite This Article

TABASUM, S., KHARE, S., JAIN, K. (2022). Subchronic Toxicity Assessment of Orally Administered Methanol (70%) Seed Extract of Abrus precatorius L. in Wistar Albino Rats. Turkish Journal of Pharmaceutical Sciences, Cilt: 16 - Sayı: 1, 88–95. https://ajindex.com/articles/613790

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