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Journals / Turkish Journal of Pharmaceutical Sciences / 2019 / Cilt: 16 - Sayı: 3

Phytochemical Screening and Metallic Ion Content and Its Impact on the Antipsoriasis Activity of Aqueous Leaf Extracts of Calendula officinalis and Phlebodium decumanum in an Animal Experiment Model

Calendula officinalis ve Phlebodium decumanum Sulu Yaprak Ekstreleri Üzerinde Fitokimyasal Tarama, Metalik İyon İçeriği ve Hayvan Deneyi Modelinde Antipsoriasis Etkisi

Kuntal DAS
Someswar DEB
Tejaswini KARANTH
Pages
292–302
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Further content of phytochemicals in terms ofextract was correlated with the effect of psoriasis activity.Results: We observed redness, erythema, and scales and the histological features and found a progressive reduction (P

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The aim of this study was to evaluate the influence of metal ions present in soil as well as in leaf samples of Calendula officinalis andPhlebodium decumanum for the treatment of psoriasis.Materials and Methods: To meet the objective, soil and leaf samples were estimated for metal ions by atomic absorption spectrophotometer todetermine the influence in antipsoriatic activity.
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Key Findings & Data:Two plant extracts(aqueous) separately as well as in combinations and standard Retino-A (0.05%) were used.
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Conclusion & Impact:Further content of phytochemicals in terms ofextract was correlated with the effect of psoriasis activity.Results: We observed redness, erythema, and scales and the histological features and found a progressive reduction (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: The aim of this study was to evaluate the influence of metal ions present in soil as well as in leaf samples of Calendula officinalis andPhlebodium decumanum for the treatment of psoriasis.Materials and Methods: To meet the objective, soil and leaf samples were estimated for metal ions by atomic absorption spectrophotometer todetermine the influence in antipsoriatic activity. Thereafter imiquimod-induced dermatitis lesions were created in grouped mice. Two plant extracts(aqueous) separately as well as in combinations and standard Retino-A (0.05%) were used. Psoriasis severity index (PSI) was evaluated accordingto the phenotypic (redness, erythema, and scales) and histological features (epidermal thickness). Further content of phytochemicals in terms ofextract was correlated with the effect of psoriasis activity.Results: We observed redness, erythema, and scales and the histological features and found a progressive reduction (P

Özet

Amaç: Bu çalışmanın amacı, Calendula officinalis ve Phlebodium decumanum yaprak örneklerinde, toprakta da bulunan metal iyonlarının psoriazis tedavisi üzerindeki etkilerini değerlendirmektir. Gereç ve Yöntemler: Bu amaçla, antipsoriatik etkiyi belirlemek üzere toprak ve yaprak örneklerindeki metal iyonları atomik absorpsiyon spektrofotometresi ile tayin edilmiştir. Daha sonra farelerde, imikimod-nedenli dermatit lezyonları oluşturuldu. İki bitki ekstresi (sulu) ayrı ayrı ve karışım halinde uygulanmış ve standart olarak Retino-A (% 0.05) kullanılmıştır. Psoriasis şiddet indeksi (PSI) fenotipik (kızarıklık, eritem ve pullanma) ve histolojik özelliklere (epidermal kalınlık) göre değerlendirilmiştir. Ekstre içindeki fitokimyasalların, sedef hastalığına karşı etki ile korele olduğu belirlendi. Bulgular: 200 mg/kg dozda ekstre karışımı uygulanan hayvanlarda kızarıklık, eritem, pullanma ve histolojik özelikler izlenmiş, bunun sonucunda psoriatik lezyonlarda 7. günden 21. güne kadar progresif bir azalma (p

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Cite This Article

DAS, K., DEB, S., KARANTH, T. (2022). Phytochemical Screening and Metallic Ion Content and Its Impact on the Antipsoriasis Activity of Aqueous Leaf Extracts of Calendula officinalis and Phlebodium decumanum in an Animal Experiment Model. Turkish Journal of Pharmaceutical Sciences, Cilt: 16 - Sayı: 3, 292–302. https://ajindex.com/articles/613787

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