Journals / Turkish Journal of Pharmaceutical Sciences / 2019 / Cilt: 16 - Sayı: 2

Phytotherapy as a Complementary Medicine for Multiple Sclerosis

Multipl Sklerozda Tamamlayıcı Tedavi Olarak Fitoterapi

Pages
246–251
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Medicinal plants and their compounds can serve as new sourcesof MS drugs because they can improve MS symptoms.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Multiple sclerosis (MS) is the most common cause of neurologic disability in adults worldwide.
📊
Key Findings & Data:The people with MS, therefore, seek out complementary and alternative medications to manage the symptoms of this disease.Meanwhile, medicinal plants have been demonstrated to have possible positive pharmacological effects in treating MS in different models.
💡
Conclusion & Impact:Medicinal plants and their compounds can serve as new sourcesof MS drugs because they can improve MS symptoms.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Multiple sclerosis (MS) is the most common cause of neurologic disability in adults worldwide. Two main issues have caused MS patients to faceseveral problems. One issue is that the definite cause of MS has not yet been determined and the other issue is the lack of a definite treatmentfor this disease. The people with MS, therefore, seek out complementary and alternative medications to manage the symptoms of this disease.Meanwhile, medicinal plants have been demonstrated to have possible positive pharmacological effects in treating MS in different models. Thereliable articles indexed in the databases Web of Science, Scopus, PubMed Central, PubMed, Scientific Information Database, and Institute for ScientificInformation were retrieved and analyzed to conduct this review. Medicinal plants and plant compounds caused decreases in the neurologic deficitsdue to MS. Clinical evidence has demonstrated the clinical potential of Cannabis sativa extract, cannabinoids, Ginkgo biloba, beta-phytosterol, andLippia citriodora extract to improve MS symptoms. These plants and compounds can also improve spasticity, muscle spasm, neuropathic pain, andurinary tract complications in at least some of these patients. Nanocurcumins and Punica granatum L. peel extract have exhibited positive effectsin animal models and can decrease neurologic deficits by reducing inflammation. Medicinal plants and their compounds can serve as new sourcesof MS drugs because they can improve MS symptoms.

Özet

Multipl skleroz (MS), dünya çapında yetişkinlerde en sık görülen nörolojik problemdir. MS hastalarının pek çok sorunla karşı karşıya kalmasına neden olan iki ana sorun bulunmaktadır. İlk sorun, MS’in kesin nedeninin henüz belirlenmemiş olmasıdır. Diğer problem ise bu hastalık için kesin bir tedavinin olmayışıdır. Bu nedenle, MS’li hastalar, bu hastalığın semptomlarını giderebilmek için tamamlayıcı ve alternatif tedavi arayışındadırlar. Aynı zamanda, tıbbi bitkilerin, MS’in farklı modellerde tedavisinde olası olumlu farmakolojik etkilere sahip olduğu gösterilmiştir. Bu derlemenin hazırlanmasında, Web of Science, Scopus, PubMed Central, PubMed, Scientific Information Database ve Institute for Scientific Information gibi veri tabanlarında indekslenen güvenilir makalelere başvurulmuş ve değerlendirilmiştir. Tıbbi bitkiler ve bitkisel bileşikler, MS kaynaklı nörolojik problemlerin azalmasını sağlamıştır. Klinik çalışmalar, MS semptomlarını iyileştirmek için Cannabis sativa ekstresi, kannabinoidler, Ginkgo biloba, beta-fitosterol ve Lippia citriodora ekstresinin klinik potansiyelini ortaya koymuştur. Bu bitkiler ve bileşikler, bu hastaların en azından bazılarında spastisite, kas spazmı, nöropatik ağrı ve idrar yolu komplikasyonlarını iyileştirebilmektedir. Nanokurkuminler ve Punica granatum L. kabuğu ekstresi, hayvan modelleri üzerinde olumlu etkiler göstermiş ve inflamasyonu azaltarak nörolojik bozuklukları azaltmıştır. Tıbbi bitkiler ve bunların bileşikleri, MS semptomlarını iyileştirebildikleri için yeni MS ilaç kaynakları olarak kullanılabilir.

🔖

Cite This Article

RABIEI, Z. (2022). Phytotherapy as a Complementary Medicine for Multiple Sclerosis. Turkish Journal of Pharmaceutical Sciences, Cilt: 16 - Sayı: 2, 246–251. https://ajindex.com/articles/613782

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Franklin RJ. Why does remyelination fail in multiple sclerosis? Nat Rev Neurosci. 2002;3:705-714
  2. McQualter JL, Bernard CC. Multiple sclerosis: a battle between destruction and repair. J Neurochem 2007;100:295-306
  3. Olsen SA. A review of complementary and alternative medicine (CAM) by people with multiple sclerosis. Occup Ther Int. 2009;16:57-70
  4. Mirzai V, Saiadi AR, Heydarinasab M. Knowledge and attitude of Rafsanjan physicians about complementary and alternative medicine. Zahedan J Res Med Sci. 2011;13:20-24
  5. Goodin DS, Frohman EM, Garmany GP Jr, Halper J, Likosky WH, Lublin FD, Silberberg DH, Stuart WH, van den Noort S; Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines. Disease modifying therapies in multiple sclerosis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines. Neurology. 2002;58:169-178
  6. Yadav V, Bever C Jr, Bowen J, Bowling A, Weinstock-Guttman B, Cameron M, Bourdette D, Gronseth GS, Narayanaswami P. Summary of evidence-based guideline: Complementary and alternative medicine in multiple sclerosis Report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2014;82:1083-1092
  7. Rabiei Z, Rafieian-kopaei M, Heidarian E, Saghaei E, Mokhtari S. Effects of Zizyphus jujube extract on memory and learning impairment induced by bilateral electric lesions of the nucleus Basalis of Meynert in rat. Neurochem Res. 2014;39:353-360
  8. Rabiei Z, Mokhtari S, Asgharzade S, Gholami M, Rahnama S, Rafieiankopaei M. Inhibitory effect of Thymus vulgaris extract on memory impairment induced by scopolamine in rat. Asian Pac J Trop Biomed. 2015;5:845-851
  9. Rabiei Z, Rafieian-Kopaei M. Neuroprotective effect of pretreatment with Lavandula officinalis ethanolic extract on blood-brain barrier permeability in a rat stroke model. Asian Pac J Trop Med. 2014;7:421- 426
  10. Rabiei Z, Bigdeli MR, Rasoulian B, Ghassempour A, Mirzajani F. The neuroprotection effect of pretreatment with olive leaf extract on brain lipidomics in rat stroke model. Phytomedicine. 2012;19:940-946
  11. Rabiei Z, Gholami M, Rafieian-Kopaei M. Antidepressant effects of Mentha pulegium in mice. Bangladesh J Pharmacol. 2016;11:711-715
  12. Rabiei Z, Naderi S, Rafieian-Kopaei M. Study of antidepressant effects of grape seed oil in male mice using tail susp