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Journals / Turkish Journal of Pharmaceutical Sciences / 2020 / Cilt: 17 - Sayı: 6

Evaluation of the Antioxidant Activity of Some Imines Containing 1H-Benzimidazoles

1H-Benzimidazol İçeren Bazı İminlerin Antioksidan Aktivitesinin Değerlendirilmesi

Rahman BAŞARAN
Gülgün KILCIGİL
Benay EKE
Pages
626–630
Publication Date
2022-11-04
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

None of the synthesised compounds had a marked inhibitory effecton EROD activity.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The in vitro antioxidant properties of some 2-(2-phenyl)-1H-benzo(d)imidazol-1-yl)-N’-(arylmethylene) acetohydrazide derivatives (1-12)were investigated in this study.Materials and Methods: The in vitro antioxidant activity of compounds 1-12 was explored by determination of rat liver microsomal nicotinamideadenine dinucleotide phosphate dependent inhibition on lipid peroxidation (LPO) levels and microsomal ethoxyresorufin O-deethylase (EROD)activity.Results: All synthesised compounds had LPO inhibitory activity (15-57%) except compound 6, which contains a thiophene ring.
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Key Findings & Data:Almost all thecompounds displayed slightly inhibitory activity (2-20%) on EROD.Conclusion: The most active compound, 3 bearing a p-bromophenyl substituent at the second position of the benzimidazole ring, caused 57%inhibition of LPO level, while butylated hydroxytoluene showed 65% inhibition.
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Conclusion & Impact:None of the synthesised compounds had a marked inhibitory effecton EROD activity.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: The in vitro antioxidant properties of some 2-(2-phenyl)-1H-benzo(d)imidazol-1-yl)-N’-(arylmethylene) acetohydrazide derivatives (1-12)were investigated in this study.Materials and Methods: The in vitro antioxidant activity of compounds 1-12 was explored by determination of rat liver microsomal nicotinamideadenine dinucleotide phosphate dependent inhibition on lipid peroxidation (LPO) levels and microsomal ethoxyresorufin O-deethylase (EROD)activity.Results: All synthesised compounds had LPO inhibitory activity (15-57%) except compound 6, which contains a thiophene ring. Almost all thecompounds displayed slightly inhibitory activity (2-20%) on EROD.Conclusion: The most active compound, 3 bearing a p-bromophenyl substituent at the second position of the benzimidazole ring, caused 57%inhibition of LPO level, while butylated hydroxytoluene showed 65% inhibition. None of the synthesised compounds had a marked inhibitory effecton EROD activity.

Özet

Amaç: Bu çalışmada, bazı 2-(2-fenil)-1H-benzo(d)imidazol-1-il)-N’-(arilmetilen) asetohidrazit türevlerinin in vitro antioksidan özellikleri araştırılmıştır. Gereç ve Yöntemler: 1-12 numaralı bileşiklerin in vitro antioksidan aktiviteleri, lipit peroksidasyon (LPO) düzeylerine sıçan karaciğer mikrozomal nikotinamid adenin dinükleotid fosfat bağımlı inhibisyonunu ve mikrozomal etoksirezorufin O-deetilaz (EROD) aktivitesinin belirlenmesiyle incelenmiştir. Bulgular: Tiyofen halkası içeren bileşik 6 dışında, sentezlenen tüm bileşikler LPO inhibitör aktivite (%15-57) göstermiştir. Hemen hemen tüm bileşikler az miktarda EROD inhibe edici aktivite (%2-20) göstermiştir. Sonuç: Benzimidazol halkasının ikinci konumunda p-bromo fenil sübstitüenti taşıyan bileşik 3, LPO seviyesinde %57 inhibisyona neden olan en aktif bileşik iken, butillenmiş hidroksitoluen %65 inhibisyon göstermiştir. Sentezlenen bileşiklerin hiçbiri EROD aktivitesi üzerinde belirgin bir inhibisyon etkisine sahip değildir

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Cite This Article

BAŞARAN, R., KILCIGİL, G., EKE, B. (2022). Evaluation of the Antioxidant Activity of Some Imines Containing 1H-Benzimidazoles. Turkish Journal of Pharmaceutical Sciences, Cilt: 17 - Sayı: 6, 626–630. https://ajindex.com/articles/613754

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