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Journals / Turkish Journal of Pharmaceutical Sciences / 2020 / Cilt: 17 - Sayı: 3

Phytochemical Constituents, Antioxidant Activity, and Toxicity Assessment of the Seed of Spondias mombin L. (Anacardiaceae)

Spondias mombin L. (Anacardiaceae) Tohumunun Fitokimyasal Bileşenleri, Antioksidan Aktivitesi ve Toksisite Değerlendirmesi

Oyindamola Olajumoke ABIODUN
Mesoma Esther NNORUKA
Rasidat Olufunke TIJANI
Pages
343–348
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

The phytochemical constituents of MESSM were identified using gas chromatography-mass spectrometry.Results: MESSM produced better antioxidant activity in the DPPH (IC50=58.64±1.49 µg/mL) and H2O2 (IC50=44.03±5.57 µg/mL) assays than in theNO (IC50=494.55±12.68 µg/mL, p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Increased generation of free radicals exceeding the antioxidant capacity of the host is deleterious.
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Key Findings & Data:Therefore, the antioxidant activity, cytotoxicity potential, and phytochemicalconstituents of the methanol extract of Spondias mombin seed (MESSM) were investigated.Materials and Methods: 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO), and hydrogen peroxide (H2O2) were the antioxidant assays used.The cytotoxicity of MESSM was evaluated against a rhabdomyosarcoma (RD) cell line in a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazoliumbromide based assay.
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Conclusion & Impact:The phytochemical constituents of MESSM were identified using gas chromatography-mass spectrometry.Results: MESSM produced better antioxidant activity in the DPPH (IC50=58.64±1.49 µg/mL) and H2O2 (IC50=44.03±5.57 µg/mL) assays than in theNO (IC50=494.55±12.68 µg/mL, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Increased generation of free radicals exceeding the antioxidant capacity of the host is deleterious. Thus new, potent, and safe antioxidantswill be a valuable addition to the limited antioxidant arsenals available. Therefore, the antioxidant activity, cytotoxicity potential, and phytochemicalconstituents of the methanol extract of Spondias mombin seed (MESSM) were investigated.Materials and Methods: 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO), and hydrogen peroxide (H2O2) were the antioxidant assays used.The cytotoxicity of MESSM was evaluated against a rhabdomyosarcoma (RD) cell line in a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazoliumbromide based assay. The phytochemical constituents of MESSM were identified using gas chromatography-mass spectrometry.Results: MESSM produced better antioxidant activity in the DPPH (IC50=58.64±1.49 µg/mL) and H2O2 (IC50=44.03±5.57 µg/mL) assays than in theNO (IC50=494.55±12.68 µg/mL, p

Özet

Amaç: Konağın antioksidan kapasitesini aşan serbest radikallerin artması zararlıdır. Bu nedenle, yeni, güçlü ve güvenli antioksidanlar, mevcut sınırlı antioksidanlara değerli katkı sağlayacaktır. Bu nedenle, Spondias mombin tohumunun (MESSM) metanol ekstraktının antioksidan aktivitesi, sitotoksisite potansiyeli ve fitokimyasal bileşenleri araştırıldı. Gereç ve Yöntemler: 2,2-difenil-1-pikrilhidrazil (DPPH), nitrik oksit (NO) ve hidrojen peroksit (H2 O2 ) kullanılan antioksidan deneylerdi. MESSM’nin sitotoksisitesi, 3-(4,5- dimetil tiyazol-2-yl)-2,5- difenil tetrazolium bromür ile bir rabdomiyosarkom (RD) hücre hattında değerlendirildi. MESSM’nin fitokimyasal bileşenleri gaz kromatografisi-kütle spektrometresi kullanılarak tanımlandı. Bulgular: MESSM, DPPH (IC50=58,64±1,49 µg/mL) ve H2 O2(IC50=44,03±5,57 µg/mL) deneylerinde NO (IC50=494,55±12,68 µg/mL, p

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Cite This Article

ABIODUN, O. O., NNORUKA, M. E., TIJANI, R. O. (2022). Phytochemical Constituents, Antioxidant Activity, and Toxicity Assessment of the Seed of Spondias mombin L. (Anacardiaceae). Turkish Journal of Pharmaceutical Sciences, Cilt: 17 - Sayı: 3, 343–348. https://ajindex.com/articles/613742

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References (17)

  1. Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012;5:9-19
  2. Bogdan AI, Baumann L. Antioxidants used in skin care formulations. Skin Therapy Lett. 2018;13:5-9
  3. Tezel G. Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. Prog Retin Eye Res. 2006;25:490-513
  4. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010;4:118- 126
  5. Butterfield DA, Drake J, Pocernich C, Castegna A. Evidence of oxidative damage in Alzheimer’s disease brain: central role for amyloid β-peptide. Trends Mol Med. 2001;7:548-554
  6. Agil A, Durán R, Barrero F, Morales B, Araúzo M, Alba F, Miranda MT, Prieto I, Ramírez M, Vives F. Plasma lipid peroxidation in sporadic Parkinson’s. Role of the L-dopa. J Neurol Sci. 2006;240:31-36
  7. Kim JI, Cho SI, Kim NH, Jin JK, Choi EK, Carp RI, Kim YS. Oxidative stress and neurodegeneration in prion diseases. Ann N Y Acad Sci. 2001;928:182-186
  8. He L, He T, Farrar S, Linbao J, Liu T, Ma Xi. Antioxidants and Cellular Homeostasis by Elimination of Reactive Oxygen Species. Cell Physiol Biochem. 2017;44:532-553
  9. Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009;2:270-278
  10. Simo A, Kawal N, Paliyath G, Bakovic M. Botanical antioxidants for skin health in the world of cosmeceuticals. International Journal of Advanced Nutritional and Health Science. 2014;2:67-88
  11. López VGC, Cortés RC. Medicinal plants, antioxidants and health. J Tox Health. 2013;103:257-265
  12. Gülçin I, Berashvili D, Gepdiremen A. Antiradical and antioxidant activity of total anthocyanins from Perilla pankinensis decne. J Ethnopharmacol. 2005;101:287-293
  13. Irvine JR. Woody plants of Ghana. 2nd ed. London: Oxford University press; 1961:51
  14. Abo KA, Ogunleye VO, Ashidi JS. Antimicrobial potential of Spondias mombin, Croton zambesicus and Zygotritonia crocea. Phytother Res. 1999;13:494-497
  15. Ajao AO, Shonukan O, Onadeko BF. Antibacterial effect of aqueous and alcohol extracts of Spondias mombin and Alchomea cordifolia - Two local antimicrobial remedies. Int J Crude Drug Res. 1985;23:67-72
  16. Akubue PI, Mittal GC, Aguwa CN. Preliminary pharmacological study of some Nigerian medicinal plants. J Ethnopharmacol. 1983;8:53-63
  17. Corthout J, Pieters LA, Claeys M, Vanden BDA, Viletinck AJ. Antiviral; Ellagitannins fro