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Journals / Turkish Journal of Pharmaceutical Sciences / 2020 / Cilt: 17 - Sayı: 6

Tualang Honey Improves Memory and Prevents Hippocampal Changes in Prenatally Stressed Rats

Prenatal Olarak Strese Maruz Kalan Erişkin Sıçanlarda Tualang Balının Hafızayı Güçlendirmesi ve Hippokampal Değişiklikleri Önlemesi

Hidani HASIM
Rahimah ZAKARIA
Che Badariah ABD AZIZ
Asma Hayati AHMAD
Pages
620–625
Publication Date
2022-11-02
DOI
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Their brains were removed and histological changes and levels of MDA and NMDA receptors in the hippocampus were determined.Results: The offspring from TH group showed significantly increased preference index (p

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Objective & Hypothesis:Objectives: This study investigated whether the alterations in memory and hippocampus morphology and levels of malondialdehyde (MDA) andN-methyl-D-aspartate (NMDA) receptor in the hippocampus of adult rats after prenatal stress could be prevented by administration of Tualanghoney (TH).Materials and Methods: Twenty-four pregnant rats were randomly grouped into a control group (C), a stress group (S), and a stress group treatedwith TH.
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Key Findings & Data:Eight male pups from each group were randomly chosen and they were sacrificed at eight or ten weeks of age following the novel objectrecognition test.
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Conclusion & Impact:Their brains were removed and histological changes and levels of MDA and NMDA receptors in the hippocampus were determined.Results: The offspring from TH group showed significantly increased preference index (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: This study investigated whether the alterations in memory and hippocampus morphology and levels of malondialdehyde (MDA) andN-methyl-D-aspartate (NMDA) receptor in the hippocampus of adult rats after prenatal stress could be prevented by administration of Tualanghoney (TH).Materials and Methods: Twenty-four pregnant rats were randomly grouped into a control group (C), a stress group (S), and a stress group treatedwith TH. Eight male pups from each group were randomly chosen and they were sacrificed at eight or ten weeks of age following the novel objectrecognition test. Their brains were removed and histological changes and levels of MDA and NMDA receptors in the hippocampus were determined.Results: The offspring from TH group showed significantly increased preference index (p

Özet

Amaç: Bu çalışma prenatal olarak strese maruz kalan erişkin sıçanlarda Tualang balı (TH) uygulamasının hafıza ve hippokampal morfoloji değişikliklerini ve malondialdehit ve N-metil-D-aspartat (NMDA) reseptör düzeylerindeki farklılıkları önleyip önlemeyeceğini belirlemek için gerçekleştirilmiştir. Gereç ve Yöntemler: Yirmi dört gebe sıçan kontrol grubu (C), stres grubu (S) ve TH uygulanan stres grubu olarak randomize olarak gruplanmıştır. Bu annelerden doğan 24 yavru erişkinliğe geldiklerinde yeni obje tanıma testi yapıldıktan sonra sakrifiye edilmiştir. Beyinleri çıkartılmış ve histopatolojik değişiklikler, MDA ve hipokampüsteki NMDA reseptör düzeyleri belirlenmiştir. Bulgular: TH grubundan alınan yavrular, S grubuna kıyasla daha yüksek nöron sayısı ile belirgin bir şekilde artmış tercih indeksi (p

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Cite This Article

HASIM, H., ZAKARIA, R., AZIZ, C. B. A., AHMAD, A. H. (2022). Tualang Honey Improves Memory and Prevents Hippocampal Changes in Prenatally Stressed Rats. Turkish Journal of Pharmaceutical Sciences, Cilt: 17 - Sayı: 6, 620–625. https://ajindex.com/articles/613706

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