Journals / Turkish Journal of Pharmaceutical Sciences / 2021 / Cilt: 18 - Sayı: 4

Effects of Bee Propolis on FBG, HbA1c, and Insulin Resistance in Healthy Volunteers

Sağlıklı Gönüllülerde Arı Propolisinin FBG, HbA1c ve İnsülin Direnci Üzerine Etkileri

Pages
30–33
Publication Date
2022-11-02
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Based on these results, bee propolis supplementation has a potential effect on glycemic control in healthy individuals and this should be considered when using this supplement in medical conditions.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Bee propolis is a natural substance that is used in traditional medicine due to its versatile pharmacological actions.
📊
Key Findings & Data:Materials and Methods: A single daily dose of 1000 mg of bee propolis was administered orally to a total of 34 healthy individuals for 60 days.
💡
Conclusion & Impact:Conclusion: Based on these results, bee propolis supplementation has a potential effect on glycemic control in healthy individuals and this should be considered when using this supplement in medical conditions.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Bee propolis is a natural substance that is used in traditional medicine due to its versatile pharmacological actions. This study evaluates whether short term use of bee propolis supplementation could have an impact on glycemic control in healthy individuals. Materials and Methods: A single daily dose of 1000 mg of bee propolis was administered orally to a total of 34 healthy individuals for 60 days. Body weight, body mass index (BMI), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), and insulin resistance were measured in all participants before and after the use of bee propolis. Results: The results of this study showed that bee propolis was associated with a significant increase in body weight and BMI of healthy volunteers. Bee propolis supplementation decreased FBG and HbA1c, but did not affect insulin resistance. Conclusion: Based on these results, bee propolis supplementation has a potential effect on glycemic control in healthy individuals and this should be considered when using this supplement in medical conditions.

Özet

Amaç: Arı propolisi, çok yönlü farmakolojik etkileri nedeniyle geleneksel tıpta kullanılan doğal bir maddedir. Bu çalışma, kısa süreli arı propolis takviyesi kullanımının sağlıklı bireylerde glisemik kontrol üzerinde bir etkisi olup olmadığını değerlendirmektedir. Gereç ve Yöntemler: Toplam 34 sağlıklı bireye 60 gün boyunca günde tek doz 1000 mg arı propolisi oral yoldan verilmiştir. Arı propolisinin kullanımı öncesi ve sonrasında tüm katılımcılarda vücut ağırlığı, vücut kitle indeksi (VKİ), açlık kan şekeri (AKŞ), glikozile hemoglobin (HbA1c) ve insülin direnci ölçülmüştür. Bulgular: Bu çalışmanın sonuçları, arı propolisinin sağlıklı gönüllülerin vücut ağırlığında ve VKİ’sinde belirgin bir artış ile ilişkili olduğunu göstermiştir. Arı propolisi takviyesi AKŞ ve HbA1c’yi azaltmış, ancak insülin direncini etkilememiştir. Sonuç: Bu sonuçlara dayanarak, arı propolis takviyesinin sağlıklı bireylerde glisemik kontrol üzerinde potansiyel bir etkisi olduğu söylenebilir ve bu takviye tıbbi durumlarda kullanılırken bu dikkate alınmalıdır.

🔖

Cite This Article

ALASSAF, F. A., JASIM, M. H. M., ALFAHAD, M., QAZZAZ, M. E., ABED, M. N., THANOON, I. A. (2022). Effects of Bee Propolis on FBG, HbA1c, and Insulin Resistance in Healthy Volunteers. Turkish Journal of Pharmaceutical Sciences, Cilt: 18 - Sayı: 4, 30–33. https://ajindex.com/articles/613612

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Búfalo MC, Candeias JM, Sforcin JM. In vitro cytotoxic effect of Brazilian green propolis on human laryngeal epidermoid carcinoma (HEp-2) cells. Evid Based Complement Alternat Med. 2009;6:483-487. Ghisalberti EL. Propolis: A review. Bee World. 1979;60:59-84. Burdock GA. Review of the biological properties and toxicity of bee propolis (propolis). Food Chem Toxicol. 1998;36:347-363.
  2. Pietta PG, Gardana C, Pietta AM. Analytical methods for quality control of propolis. Fitoterapia. 2002;73(Suppl 1):S7-S20. Verma MK, Pandey RK, Khanna R, Agarwal J. The antimicrobial effectiveness of 25% propolis extract in root canal irrigation of primary teeth. J Indian Soc Pedod Prev Dent. 2014;32:120-124.
  3. Bueno-Silva B, Rosalen PL, Alencar SM, Mayer MPA. Anti-inflammatory mechanisms of neovestitol from Brazilian red propolis in LPS-activated macrophages. J Funct Foods. 2017;36:440-447.
  4. Zhang J, Shen X, Wang K, Cao X, Zhang C, Zheng H, Hu F. Antioxidant activities and molecular mechanisms of the ethanol extracts of Baccharis propolis and Eucalyptus propolis in RAW64.7 cells. Pharm Biol. 2016;54:2220-2235.
  5. Sartori G, Pesarico AP, Pinton S, Dobrachinski F, Roman SS, Pauletto F, Rodrigues LC Jr, Prigol M. Protective effect of brown Brazilian propolis against acute vaginal lesions caused by herpes simplex virus type 2 in mice: involvement of antioxidant and anti-inflammatory mechanisms. Cell Biochem Funct. 2012;30:1-10.
  6. Demir S, Aliyazicioglu Y, Turan I, Misir S, Mentese A, Yaman SO, Akbulut K, Kilinc K, Deger O. Antiproliferative and proapoptotic activity of Turkish propolis on human lung cancer cell line. Nutr Cancer. 2016;68:165-172.
  7. Orsatti CL, Missima F, Pagliarone AC, Bachiega TF, Búfalo MC, Araújo JP Jr, Sforcin JM. Propolis immunomodulatory action in vivo on Tolllike receptors 2 and 4 expression and on pro-inflammatory cytokines production in mice. Phytother Res. 2010;24:1141-1146.
  8. Tolba MF, Azab SS, Khalifa AE, Abdel-Rahman SZ, Abdel-Naim AB. Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities: a review on its anti-inflammatory, neuroprotective, hepatoprotective, and cardioprotective effects. IUBMB Life. 2013;65:699-709.
  9. Babatunde IR, Abdulbasit A, Oladayo MI, Olasile OI, Olamide FR, Gbolahan BW. Hepatoprotective and pancreatoprotective properties of the ethanolic extract of nigerian propolis. J Intercult Ethnopharmacol. 2015;4:102-108.
  10. Toreti VC, Sato HH, Pastore GM, Park YK. Recent progress of propolis for its biolog