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Journals / Turkish Journal of Pharmaceutical Sciences / 2021 / Cilt: 18 - Sayı: 1

A Synbiotic Mixture Ameliorates Depressive Behavior Induced by Dexamethasone or Water Avoidance Stress in a Mouse Model

Fare Modelinde Deksametazon ile İndüklenen Depresif Davranışı veya Sudan Kaçınma Stresini İyileştiren Sinbiyotik Bir Karışım

Azadeh MESRIPOUR
Pooya RAKHSHANKHAH
Pages
21–27
Publication Date
2022-11-02
DOI
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Results: Drinking the synbiotic reduced immobility time during the FST (54±7 sec vs. 111±6 sec in the control water group, p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Disruption of the hypothalamic-pituitary-adrenal axis by stress and glucocorticoid drugs is a major cause of depression.
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Key Findings & Data:The synbiotic regimen (12.5x106CFU) was supplemented in drinking water for 7 days.
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Conclusion & Impact:Results: Drinking the synbiotic reduced immobility time during the FST (54±7 sec vs. 111±6 sec in the control water group, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Disruption of the hypothalamic-pituitary-adrenal axis by stress and glucocorticoid drugs is a major cause of depression. The benefits of probiotics may extend to systems beyond the gastrointestinal tract, i.e., the central nervous system. Therefore, the effect of a synbiotic (probiotic + prebiotic) mixture on dexamethasone (Dex) and stress-induced depression was investigated. Materials and Methods: Male albino mice were used, the forced swimming test (FST) measured despair, and the sucrose preference test measured anhedonia. The synbiotic regimen (12.5x106CFU) was supplemented in drinking water for 7 days. Dex was administered subcutaneously either in a single dose on the test day or for 7 days. Water avoidance stress (WAS) was induced for 1 hour each day for 4 days. Results: Drinking the synbiotic reduced immobility time during the FST (54±7 sec vs. 111±6 sec in the control water group, p

Özet

Amaç: Hipotalamik-hipofiz-adrenal eksenin stres ve glukokortikoid ilaçlarla bozulması, depresyonun başlıca nedenidir. Probiyotiklerin faydaları, gastrointestinal sistemin ötesindeki sistemlere, yani merkezi sinir sistemine kadar uzanabilir. Bu nedenle, bir sinbiyotik (probiyotik + prebiyotik) karışımın deksametazon (Dex) ve stres kaynaklı depresyon üzerindeki etkisi araştırıldı. Gereç ve Yöntemler: Erkek albino fareler kullanıldı, zorlu yüzme testi (FST) umutsuzluğu, sükroz tercih testi ise anhedoniyi ölçmek için kullanıldı. Sinbiyotik rejim (12,5x106CFU), içme suyunda 7 gün süreyle verildi. Dex, subkutan yollan test gününde tek doz olarak veya 7 gün süreyle uygulandı. Sudan kaçınma stresi (WAS) 4 gün boyunca her gün 1 saat süreyle indüklendi. Bulgular: Sinbiyotik içilmesi FST’de hareketsizlik süresini azalttı (kontrol su grubunda 54±7 sn’ye karşılık 111±6 sn, p

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Cite This Article

MESRIPOUR, A., RAKHSHANKHAH, P. (2022). A Synbiotic Mixture Ameliorates Depressive Behavior Induced by Dexamethasone or Water Avoidance Stress in a Mouse Model. Turkish Journal of Pharmaceutical Sciences, Cilt: 18 - Sayı: 1, 21–27. https://ajindex.com/articles/613606

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References (15)

  1. Hemarajata P, Versalovic J. Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation. Therap Adv Gastroenterol. 2013;6:39-51
  2. Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol. 2009;9:313- 323
  3. Floch MH, Walker WA, Guandalini S, Hibberd P, Gorbach S, Surawicz C, Sanders ME, Garcia-Tsao G, Quigley EM, Isolauri E, Fedorak RN, Dieleman LA. Recommendations for probiotic use--2008. J Clin Gastroenterol. 2008;42(Suppl 2):S104-108
  4. Dinan TG, Cryan JF. Melancholic microbes: a link between gut microbiota and depression? Neurogastroenterol Motil. 2013;25:713-719
  5. Cerdó T, Ruíz A, Suárez A, Campoy C. Probiotic, Prebiotic, and Brain Development. Nutrients. 2017;9:1247
  6. Desbonnet L, Garrett L, Clarke G, Bienenstock J, Dinan TG. The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat. J Psychiatr Res. 2008;43:164-174
  7. Wang Y, Kasper LH. The role of microbiome in central nervous system disorders. Brain Behav Immun. 2014;38:1-12
  8. Desbonnet L, Garrett L, Clarke G, Kiely B, Cryan JF, Dinan TG. Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience 2010;170:1179-1188
  9. Savignac HM, Corona G, Mills H, Chen L, Spencer JP, Tzortzis G, Burnet PW. Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine. Neurochem Int. 2013;63:756-764
  10. Cryan JF, O’Mahony SM. The microbiome-gut-brain axis: from bowel to behavior. Neurogastroenterol Motil. 2011;23:187-192
  11. Forsythe P, Sudo N, Dinan T, Taylor VH, Bienenstock J. Mood and gut feelings. Brain Behav Immun. 2010;24:9-16
  12. Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu XN, Kubo C, Koga Y. Postnatal microbial colonization programs the hypothalamic-pituitaryadrenal system for stress response in mice. J Physiol. 2004;558(Pt 1):263-275
  13. Neufeld KM, Kang N, Bienenstock J, Foster JA. Reduced anxietylike behavior and central neurochemical change in germ-free mice. Neurogastroenterol Motil. 2011;23:255-264, e119
  14. Diaz Heijtz R, Wang S, Anuar F, Qian Y, Björkholm B, Samuelsson A, Hibberd ML, Forssberg H, Pettersson S. Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci U S A. 2011;108:3047-3052
  15. Gareau MG, Jury J, MacQueen G, Sherman PM, Perdue MH. Probiotic treatment of rat pups normalise