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Journals / Turkish Journal of Pharmaceutical Sciences / 2022 / Cilt: 19 - Sayı: 1

Determination of the Phototoxicity Potential of Commercially Available Tattoo Inks Using the 3T3- neutral Red Uptake Phototoxicity Test

Piyasada Satılan Dövme Boyalarının 3T3-nötral Kırmızısı Alım Fototoksisite Testi ile Fototoksisite Potansiyelinin Belirlenmesi

Ayse Tarbin JANNUZZI
Elif Gözde UTKU TÜRK
Buket ALPERTUNGA
Pages
70–75
Publication Date
2022-11-02
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

PIF values could not be calculated and MPE values were

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Tattooing is an ancient practice and its popularity has been increasing in the recent years.
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Key Findings & Data:In this study, the phototoxicity potential of the blue, red and black colors of the most commonly used three different commercially-available tattoo ink brands have been examined by performing in vitro 3T3-neutral red uptake (NRU) phototoxicity test.
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Conclusion & Impact:PIF values could not be calculated and MPE values were
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Tattooing is an ancient practice and its popularity has been increasing in the recent years. After tattooing, complications may occur related to compose tattoo inks. In this study, the phototoxicity potential of the blue, red and black colors of the most commonly used three different commercially-available tattoo ink brands have been examined by performing in vitro 3T3-neutral red uptake (NRU) phototoxicity test. Materials and Methods: In the study, the phototoxicity of serial diluted concentrations of tattoo inks were evaluated with in vitro 3T3-NRU phototoxicity test method according to OECD guide 432. The data obtained from the NRU test result were uploaded to Phototox software (version 2.0) and the phototoxicity potentials of tattoo inks were determined via the calculation of the mean photo effect (MPE) and photo irritation factor (PIF) values. Results: The red, black and blue colors of three different commercially available tattoo inks did not cause a cytotoxic activity on BALB/c 3T3 cells with 3T3-NRU test. The IC50 values could not be determined +ultraviolet (UV) and -UV conditions. PIF values could not be calculated and MPE values were

Özet

Amaç: Dövme yapmak eski zamanlardan beri süregelen bir uygulamadır ve popülaritesi son yıllarda artmaktadır. Dövme yapılmasından sonra dövme boyalarının bileşimine bağlı olarak çeşitli komplikasyonlar oluşabilir. Bu çalışmada, piyasada en çok kullanılan üç farklı dövme boyası markasının mavi, kırmızı ve siyah renklerinin fototoksisite potansiyeli in vitro 3T3-nötral kırmızı alım (NRU) fototoksisite testi yapılarak incelenmiştir. Gereç ve Yöntemler: Çalışmada, dövme boyalarının seri olarak seyreltilmiş konsantrasyonlarının fototoksisitesi, OECD kılavuz 432’ye göre in vitro 3T3- NRU fototoksisite test yöntemi ile değerlendirilmiştir. NRU test sonucundan elde edilen veriler Phototox yazılımıyla (sürüm 2.0) değerlendirilmiştir. Dövme boyalarının fototoksisite potansiyelleri medyan foto etki (MPE) ve foto irritan faktör (PIF) değerlerinin hesaplanmasıyla belirlenmiştir. Bulgular: Ticari olarak temin edilebilen üç farklı dövme boyasının kırmızı, siyah ve mavi renkleri, 3T3-NRU testi ile BALB/c 3T3 hücrelerinde sitotoksik aktiviteye neden olmamıştır. +Ultraviyole (UV) ve -UV koşullarında IC50 değerleri belirlenememiştir. PIF değerleri hesaplanamamıştır ve MPE değerleri

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Cite This Article

JANNUZZI, A. T., TÜRK, E. G. U., ALPERTUNGA, B. (2022). Determination of the Phototoxicity Potential of Commercially Available Tattoo Inks Using the 3T3- neutral Red Uptake Phototoxicity Test. Turkish Journal of Pharmaceutical Sciences, Cilt: 19 - Sayı: 1, 70–75. https://ajindex.com/articles/613572

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