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Journals / Turkish Journal of Obstetrics and Gynecology / 2020 / Cilt: 17 - Sayı: 4

Comparison of intramuscular versus subcutaneous aqueous progesterone for luteal phase support in artificially prepared frozen embryo transfer cycles

Hormon replasmanı ile hazırlanmış dondurulmuş embriyo transfer sikluslarında intramusküler progesteron ve su bazlı subkütanöz progesteronun luteal faz desteği açısından karşılaştırılması

Emre Niyazi TURGUT
Fazilet Kübra BOYNUKALIN
Meral GÜLTOMRUK
Zalihe YARKINER
Mustafa BAHÇECİ
Pages
16–22
Publication Date
2022-11-02
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The inclusion criteria were as follows: females aged

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Cryopreservation of embryos for future transfer attempts has noticeably increased in the last decade, especially due to the technological developments in in vitro fertlization (IVF) laboratories.
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Key Findings & Data:Materials and Methods: This retrospective, single-centre cohort study included a total of 507 AC-FET cycles performed between June 2018 and April 2020.
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Conclusion & Impact:The inclusion criteria were as follows: females aged
🔬Design:Research Article
📍Scope:2018 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Cryopreservation of embryos for future transfer attempts has noticeably increased in the last decade, especially due to the technological developments in in vitro fertlization (IVF) laboratories. In parallel, different progesterone (P) replacement regimens preceding artificially prepared frozen embryo transfer (AC-FET) attempts, especially with respect to the route of application and dosing scheme, have been widely argued so far. We aimed to provide more information about the efficacy profile of novel subcutaneous aqueous progesterone (SP) in AC-FET cycles. Materials and Methods: This retrospective, single-centre cohort study included a total of 507 AC-FET cycles performed between June 2018 and April 2020. Three hundred forty-nine (68.8%) patients received 50 mg of intramuscular progesterone as once daily, 158 (31.2%) patients received 25 mg of SP as twice daily. Only, the first and single blastocyst transfers from the same cohort were accepted. The inclusion criteria were as follows: females aged

Özet

Amaç: Son on yılda, özellikle in vitro fertilizasyon (IVF) laboratuvarında meydana gelen teknolojik gelişmeleri takiben, embriyo kriyoprezervasyonu ve bu embriyoların gelecekteki transfer işlem sayıları fark edilir bir şekilde artmıştır. Buna paralel olarak, hormon replasmanı ile hazırlanmış dondurulmuşçözülmüş embriyo transferi (HR-DÇET) öncesi uygulanan progesteron (P) yerine koyma tedavileri de, özellikle uygulama yolu ve dozları açısından daha çok tartışılmaya başlanmıştır. Bu çalışmada, yeni bir formülasyon olan su bazlı subkütanöz progesteronun (SP) HR-DÇET tedavilerindeki etkinliği hakkında daha fazla bilgi edinmeyi amaçladık. Gereç ve Yöntemler: Retrospektif, tek merkezli kohort çalışması olarak dizayn edilen bu çalışma, Haziran 2018 ve Nisan 2020 tarihleri arasında yapılan 507 tane HR-DÇET siklusunu içermektedir. Hastaların 349’unda (%68,8) 50 mg intramusküler progesteron günde bir defa, 158’inde (%32,2) ise 25 mg SP günde iki defa kullanıldı. Aynı tedavi siklusunda elde edilen ve dondurulan blastokistlerden sadece bir tanesinin transferi değerlendirmeye alındı. Aynı hastanın tekrarlayan tedavi siklusları çalışmaya dahil edilmedi. Dahil edilme kriterleri; kadın yaşı

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Cite This Article

TURGUT, E. N., BOYNUKALIN, F. K., GÜLTOMRUK, M., YARKINER, Z., BAHÇECİ, M. (2022). Comparison of intramuscular versus subcutaneous aqueous progesterone for luteal phase support in artificially prepared frozen embryo transfer cycles. Turkish Journal of Obstetrics and Gynecology, Cilt: 17 - Sayı: 4, 16–22. https://ajindex.com/articles/612948

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