Journals / Turkish Journal of Obstetrics and Gynecology / 2022 / Cilt: 19 - Sayı: 2

Outcome in women undergoing uterine artery embolization for arterio-venous malformation diagnosed post-pregnancy-A retrospective study

Gebelik sonrası tanı konulan arteriyovenöz malformasyon nedeniyle uterin arter embolizasyonu uygulanan kadınlarda sonlanım-Retrospektif bir çalışma

Pages
111–117
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: UAE is an effective treatment modality for the management of symptomatic post-pregnancy AVMs

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: To analyse the outcome of patients with symptomatic arterio-venous malformation (AVM), formed following pregnancy and managed by uterine artery embolization (UAE).
📊
Key Findings & Data:Materials and Methods: This retrospective study was conducted after ethical approval and included 15 patients presenting with abnormal uterine bleeding following pregnancy, who were suspected to have an AVM which later was confirmed by angiography and managed with UAE.
💡
Conclusion & Impact:Conclusion: UAE is an effective treatment modality for the management of symptomatic post-pregnancy AVMs
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To analyse the outcome of patients with symptomatic arterio-venous malformation (AVM), formed following pregnancy and managed by uterine artery embolization (UAE). Materials and Methods: This retrospective study was conducted after ethical approval and included 15 patients presenting with abnormal uterine bleeding following pregnancy, who were suspected to have an AVM which later was confirmed by angiography and managed with UAE. Presenting symptoms, post- UAE complications and subsequent fertility outcomes were noted. Follow-up period ranged from 6 months to 2.5 years. Results: The mean age was 28.4±3.82 years and mean parity was 1.3. Out of 15 cases, 9 (60%) presented after abortion, 4 (26.6%) after normal vaginal delivery and 2 (13.3%) after cesarean delivery; of these 10/15 (66.7%) patients had a history of curettage. The most common presenting symptom was continuous bleeding per-vaginum since the antecedent pregnancy in 9/15 (60%) patients and 6/15 (40%) patients had irregular bleeding. The mean duration of symptoms was 91±85.7 (30-360) days. For UAE, embolic agents used were polyvinyl alcohol (PVA) particles (300-500 μm) in 2 (13.3%), 30% glue injection in 3 (20%), the combination of PVA with glue injection in 4 (26.6%) and PVA with gelfoam in 6 (40%) patients. After UAE, bleeding responded within 3.6±0.97 (3-6) days in all but one patient who required repeat UAE one month later. All women resumed their normal menstrual cycle in 31.3±5.2 (24-42) days. Ten patients desired conception, of whom 5 (50%) conceived within 13.2±5.1 (6-19) months after UAE. Two women carried pregnancy to term, one underwent preterm cesarean for growth restriction with oligohydramnios. One patient had postpartum hemorrhage, which was managed medically. One had spontaneous abortion at 6 weeks gestation and the other is 13 weeks pregnant at present. Conclusion: UAE is an effective treatment modality for the management of symptomatic post-pregnancy AVMs

Özet

Amaç: Gebelikten sonra oluşan ve uterin arter embolizasyonu (UAE) ile tedavi edilen semptomatik arterio-venöz malformasyonlu (AVM) hastaların sonuçlarını analiz etmek. Gereç ve Yöntemler: Bu retrospektif çalışma, etik onay alındıktan sonra yapıldı ve gebelik sonrası anormal uterin kanama ile başvuran, AVM’si olduğundan şüphelenilen ve daha sonra anjiyografi ile doğrulanan ve UAE ile tedavi edilen 15 hastayı içeriyordu. Başvuru semptomları, UAE sonrası komplikasyonlar ve sonraki doğurganlık sonuçları not edildi. Takip süresi 6 ay ile 2,5 yıl arasında değişmekteydi. Bulgular: Ortalama yaş 28,4±3,82 yıl ve ortalama parite 1,3 idi. On beş olgunun 9’u (%60) kürtaj, 4’ü (%26,6) normal vajinal doğum ve 2’si (%13,3) sezaryen sonrası başvurdu. On (%66,7) hastanın küretaj öyküsü vardı. En sık başvuru semptomu, 9/15 (%60) hastada önceki gebelikten beri sürekli vajinal kanama idi ve 6/15 (%40) hastada düzensiz kanama mevcuttu. Ortalama semptom süresi 91±85,7 (30-360) gündü. UAE için kullanılan embolik ajanlar, 2 hastada (%13,3) polivinil alkol (PVA) partikülleri (300-500 μm), 3 hastada (%20) %30 tutkal enjeksiyonu, 4 hastada (%26,6) PVA ile tutkal enjeksiyonu kombinasyonu ve 6 hastada (%40) PVA ile jel köpüğü kombinasyonu kullanıldı. BAE’den sonra, bir ay sonra UAE’nin tekrarlanması gereken bir hasta dışında tüm hastalarda kanama 3,6±0,97 (3-6) gün içinde durduruldu. Tüm kadınlar 31,3±5,2 (24-42) günde normal adet döngüsüne döndüler. UAE’den sonra 10 hasta gebe kalmak istedi ve 5 hasta (%50) 13,2±5,1 (6-19) ay içinde gebe kaldı. İki kadında terme kadar gebelik devam ederken, bir kadına oligohidramnios ve gelişme geriliği nedeniyle erken sezaryen uygulandı. Bir hastada medikal olarak tedavi edilen doğum sonu kanama vardı. Biri 6 haftalık gebeyken spontan düşük yaptı ve diğeri şu anda 13 haftalık hamiledir. Sonuç: UAE gebelik sonrası semptomatik AVM’lerin yönetiminde etkili bir tedavi yöntemidir

🔖

Cite This Article

DADHWAL, V., SHIVHARE, S., MEENA, J., KUMAR, S., SINGHAL, S., SINGH, N., KULSHRESTHA, V., GAMANAGATTI, S. (2022). Outcome in women undergoing uterine artery embolization for arterio-venous malformation diagnosed post-pregnancy-A retrospective study. Turkish Journal of Obstetrics and Gynecology, Cilt: 19 - Sayı: 2, 111–117. https://ajindex.com/articles/612862

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Kim T, Shin JH, Kim J, Yoon HK, Ko GY, Gwon DI, et al. Management of bleeding uterine arteriovenous malformation with bilateral uterine artery embolization. Yonsei Med J 2014;55:367-73
  2. Kasznica J, Nisar N. Congenital vascular malformation of the uterus in a stillborn: a case report. Hum Pathol 1995;26:240-1
  3. Hoffman MK, Meilstrup JW, Shackelford DP, Kaminski PF. Arteriovenous malformations of the uterus: an uncommon cause of vaginal bleeding. Obstet Gynecol Surv 1997;52:736-40
  4. Kelly S, Belli A, Campbell S. Arteriovenous malformations of the uterus associated with secondary postpartum hemorrhage. Ultrasound Obstet Gynecol 2003;2:602-5
  5. Cura M, Martinez N, Cura A, Dalsaso TJ, Elmerhi F. Arteriovenous malformations of the uterus. Acta Radiol 2009;50:823-9
  6. Timmerman D, Wauters J, Van Calenbergh S, Van Schoubroeck D, MaleuxG, Van Den Bosch T, et al. Color Doppler imaging is a valuable tool for the diagnosis and management of uterine vascular malformations. Ultrasound Obstet Gynecol 2003;2:570-7
  7. Vogelzang RL, Nemcek AA, Skrtic Z, Gorrell J, Lurain JR. Uterine arteriovenous malformations: primary treatment with therapeutic embolization. J Vasc Intervent Radiol 199;2:517-22
  8. Delplanque S, Le Lous M, Proisy M, Joueidi Y, Bauville E, Rozel C, et al. Fertility, Pregnancy, and Clinical Outcomes after Uterine Arteriovenous Malformation Management. J Minim Invasive Gynecol 2019;26:153-61
  9. Peitsidis P, Manolakos E, Tsekoura V, Kreienberg R, Schwentner L. Uterine arteriovenous malformations induced after diagnostic curettage: a systematic review. Arch Gynecol Obstet 2011;284:1137-51
  10. Vilos AG, Vilos GA, Hollett-Caines J, Rajakumar C, Garvin G, et al. Uterine artery embolization for uterine arteriovenous malformation in five women desiring fertility: pregnancy outcomes. Hum Reprod 2015;30:1599-605
  11. Manolitsas T, Hurley V, Gilford E. Uterine arteriovenous malformation – a rare cause of uterine haemorrhage. Aust N Z J Obstet Gynaecol 1994;34:197-9
  12. Forssman L, Lundberg J, Scherstén T. Conservative treatment of uterine arteriovenous fistula. Acta Obstet Gynecol Scand 1982;61:85-7
  13. Steinauer JE, Diedrich JT, Wilson MW, Darney PD, Vargas JE, Drey EA. Uterine artery embolization in postabortion hemorrhage. Obstet Gynecol 2008;111:881-9
  14. Chien SC, Tseng SC, Hwa HL, Wei MC. Immediate postpartum haemorrhage caused by rupture of uterine arteriovenous malformation. Aust N Z J Obstet Gynaecol 2007;47:252-4
  15. Vilos GA, Urian R, Chan