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Journals / Turkish Journal of Medical Sciences / 2019 / Cilt: 49 - Sayı: 1

Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease

Özant HELVACI
Gül Sema KESKİN
Çağlar KESKİN
Çağrı YAYLA
Ülver B. DERİCİ
Özge T. PAŞAOĞLU
Turgay ARINSOY
Pages
139–146
Publication Date
2022-11-04
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

YKL-40 negatively correlated with eGFR and FMD values (r = –0.674and r = –0.471, respectively).Conclusion: This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements.

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Objective & Hypothesis:Background/aim: We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease.Materials and methods: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidneydisease (CKD), and 38 healthy individuals as a control group were included.
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Key Findings & Data:YKL-40 levels were measured by ELISA.
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Conclusion & Impact:YKL-40 negatively correlated with eGFR and FMD values (r = –0.674and r = –0.471, respectively).Conclusion: This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: We aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease.Materials and methods: Twenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidneydisease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelialdysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery.Results: YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower innondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = –0.674and r = –0.471, respectively).Conclusion: This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements.

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Cite This Article

HELVACI, Ö., KESKİN, G. S., KESKİN, Ç., YAYLA, Ç., DERİCİ, Ü. B., PAŞAOĞLU, Ö. T., ARINSOY, T. (2022). Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease. Turkish Journal of Medical Sciences, Cilt: 49 - Sayı: 1, 139–146. https://ajindex.com/articles/612792

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