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Journals / Turkish Journal of Medical Sciences / 1999 / Cilt: 29 - Sayı: 2

Effect of Dehydration on the Pharmacokinetics of Mefenamic Acid

Shadab QAMAR
Nadeem I. BUKHARI
Mahmood AHMAD
Muhammad JAMSHAID
Naeem A. MUZAFFAR
Pages
101–104
Publication Date
2022-11-04
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The mean plasma concentration and area under the plasma concentration-time curve decreased but the volume of distribution and total body clearance increased significantly (P

📌 3 Key Takeaways

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Objective & Hypothesis:The pharmacokinetic properties and bioavailability of mefenamic acid was studied in normal and dehydrated rabbits.
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Key Findings & Data:High perfomance liquid chromatography (HPLC) was used for the assay of mefenamic acid in plasma samples.
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Conclusion & Impact:The mean plasma concentration and area under the plasma concentration-time curve decreased but the volume of distribution and total body clearance increased significantly (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Mefenamic acid · bioavailability · anti-inflammatory drug

Abstract

The pharmacokinetic properties and bioavailability of mefenamic acid was studied in normal and dehydrated rabbits. High perfomance liquid chromatography (HPLC) was used for the assay of mefenamic acid in plasma samples. The mean plasma concentration and area under the plasma concentration-time curve decreased but the volume of distribution and total body clearance increased significantly (P

Özet

The pharmacokinetic properties and bioavailability of mefenamic acid was studied in normal and dehydrated rabbits. High perfomance liquid chromatography (HPLC) was used for the assay of mefenamic acid in plasma samples. The mean plasma concentration and area under the plasma concentration-time curve decreased but the volume of distribution and total body clearance increased significantly (P

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Cite This Article

QAMAR, S., BUKHARI, N. I., AHMAD, M., JAMSHAID, M., MUZAFFAR, N. A. (2022). Effect of Dehydration on the Pharmacokinetics of Mefenamic Acid. Turkish Journal of Medical Sciences, Cilt: 29 - Sayı: 2, 101–104. https://ajindex.com/articles/612458

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