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Journals / Turkish Journal of Medical Sciences / 2005 / Cilt: 35 - Sayı: 2

In Vitro Testing for Genotoxicity of 4-CPA by Sister Chromatid Exchange in Human Lymphocyte Culture

Gülseren BAĞCI
Göksemin DEMİR
İbrahim AÇIKBAŞ
Hüseyin BAĞCI
Pages
75–78
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

No significant change was found in sister chromatid exchange frequency at the tested 4-CPA concentration.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Certain phenoxyacetate derivatives used as plant growth regulators act as plant hormones. 2,4-D dichlorophenoxyacetic acid and 4-chlorophenoxyacetic acid are widely used in vegetable growing, especially tomatoes, in our region.
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Key Findings & Data:This is the first report of genotoxicity of 4-CPA evaluated by sister chromatid exchange in human lymphocyte culture.
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Conclusion & Impact:No significant change was found in sister chromatid exchange frequency at the tested 4-CPA concentration.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:4-CPA · Phenoxy herbicides · genotoxicity

Abstract

Certain phenoxyacetate derivatives used as plant growth regulators act as plant hormones. 2,4-D dichlorophenoxyacetic acid and 4-chlorophenoxyacetic acid are widely used in vegetable growing, especially tomatoes, in our region. These phenoxyacetic acid compounds are a potential hazard for the environment. There are conflicting results and inconsistent data about these herbicides in the literature. This is the first report of genotoxicity of 4-CPA evaluated by sister chromatid exchange in human lymphocyte culture. No significant change was found in sister chromatid exchange frequency at the tested 4-CPA concentration.

Özet

Certain phenoxyacetate derivatives used as plant growth regulators act as plant hormones. 2,4-D dichlorophenoxyacetic acid and 4-chlorophenoxyacetic acid are widely used in vegetable growing, especially tomatoes, in our region. These phenoxyacetic acid compounds are a potential hazard for the environment. There are conflicting results and inconsistent data about these herbicides in the literature. This is the first report of genotoxicity of 4-CPA evaluated by sister chromatid exchange in human lymphocyte culture. No significant change was found in sister chromatid exchange frequency at the tested 4-CPA concentration.

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Cite This Article

BAĞCI, G., DEMİR, G., AÇIKBAŞ, İ., BAĞCI, H. (2022). In Vitro Testing for Genotoxicity of 4-CPA by Sister Chromatid Exchange in Human Lymphocyte Culture. Turkish Journal of Medical Sciences, Cilt: 35 - Sayı: 2, 75–78. https://ajindex.com/articles/611971

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References (10)

  1. Topaktafl M, Rencuzoğlu E, Ila HB et al. Chromosome aberration and sister chromatid exchange in workers of the iron and steel factory of İskenderun, Turkey. Teratogenesis Carcinog Mutagen 22: 411-423, 2002.
  2. See RH, Dunn BP, Sun RH. Clastogenic activity in urine of workers occupationally exposed to pesticides. Mutat Res 241: 251-259, 1990.
  3. Kaya B, Yanikoglu A, Marcos R. Genotoxicity studies on the phenoxyacetates 2,4-D and 4-CPA in the Drosophila wing spot test. Teratogenesis Carcinog Mutagen 19: 305-312, 1999. 4. Mustonen R, Kangas J, Vuojolahti P et al. Effects of phenoxyacetic acids on the induction of chromosome aberrations in vitro and in vivo. Mutagenesis 4: 241-245, 1986. Lilienfeld DE. Gallo MA. 2.4-D, 2,4.5-T and 2.3,7.8-TCDD: An overview. Epidemiol Rev 11: 28-58, 1989. Arias E. Cytogenetic and cytokinetic effects of 2,4-D on B lymphocytes during development of the chick embryo. In Vitro Toxicol 8: 65-69, 1995. 7. Arias E. Effects of the phenoxy herbicide MCPA on SCE frequency and cell kinetics in developing chick embryos. Ecotoxicol Environ Safety 33: 25-29, 1996. 8. Kale GP, Petty BT Jr., Walker S et al. Mutagenicity testing of nine herbicides and pesticides currently used in agriculture. Environ Molec Mutagen 25: 148-153, 1995.
  4. Vogel E, Chandler JLR. Mutagenicity testing of cyclamate and some pesticides in Drosophila melanogaster. Experientia 30: 621- 623, 1974.
  5. Magnusson J, Ramel C, Eriksson A. Mutagenic effects of chlorinated phenoxyacetic acids in Drosophila melanogaster. Hereditas 87: 121-123, 1977. Seiler JP. The genetic toxicology of phenoxy acids other than 2,4,5-T. Mutation Res 55: 197-226, 1978.
  6. Moriya M, Ohta T, Watanabe K et al. Further mutagenicity studies on pesticides in bacterial reversion assay systems. Mutation Res 116: 185-216, 1983. Sorsa M. Monitoring of sister chromatid exchange and micronuclei as biological endpoints. IARC Sci Publ 59: 339-349, 1984.
  7. Sarto F, Tomanin R, Giacomelli L et al. Evaluation of chromosomal aberrations in lymphocytes and micronuclei in lymphocytes, oral mucosa and hair root cells of patients under antiblastic therapy. Mutat Res 228: 157-169, 1990.
  8. Gomez-Arroyo S. Noriega-Aldana N, Osorio A et al. Sister chromatid exchange analysis in a rural population of Mexico exposed to pesticides. Mutat Res 281: 173-179, 1992.
  9. Motykiewicz G, Michalska J, Pendzich J et al. A cytogenetic study of men environmentally and occupationally exposed to airborne pollutants. Mutat Res 280: 253-259, 1992.
  10. Rubes J, Borkovec