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Journals / Turkish Journal of Medical Sciences / 2009 / Cilt: 39 - Sayı: 2

Correlation between Calprotectin and Oxidized LDL in Preeclampsia

Sedat KADANALI
Bünyamin BÖREKÇİ
Hülya AKSOY
Nurinnisa ÖZTÜRK
Pages
191–195
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further study is necessary in order to determine whether or not high calprotectin levels prevent oxidation of circulating LDL in preeclampsia cases.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: To evaluate the relationship between serum calprotectin and oxidized low density lipoprotein (LDL) in preeclamptic patients.
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Key Findings & Data:Materials and Methods: Serum calprotectin, oxidized LDL, and MDA levels were measured in a cross-sectional study of 61 preeclamptic patients (39 severe preeclampsia and 22 mild preeclampsia cases) and 20 healthy pregnant subjects.
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Conclusion & Impact:Further study is necessary in order to determine whether or not high calprotectin levels prevent oxidation of circulating LDL in preeclampsia cases.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Calprotectin · oxidized LDL · preeclampsia

Abstract

Aim: To evaluate the relationship between serum calprotectin and oxidized low density lipoprotein (LDL) in preeclamptic patients. Additionally, we aimed to measure serum malondialdehyde (MDA) levels as an oxidative stress marker. Materials and Methods: Serum calprotectin, oxidized LDL, and MDA levels were measured in a cross-sectional study of 61 preeclamptic patients (39 severe preeclampsia and 22 mild preeclampsia cases) and 20 healthy pregnant subjects. Serum MDA concentration was measured with spectrophotometric methods, and oxidized LDL and calprotectin were measured via enzyme-linked immunoassay (ELISA). Results: Serum calprotectin (P < 0.0001 and P = 0.014) and MDA (P = 0.001 and P = 0.028) levels were significantly higher in the severe and mild preeclampsia groups than in the healthy control group. Serum oxidized LDL concentration was slightly higher, but not did reach a statistically significant level, in the severe preeclampsia group than in the healthy pregnant group (P = 0.2). There was a significant negative correlation between the levels of calprotectin and oxidized LDL (r = -0.34, P = 0.006) in the mild and severe preeclampsia groups. The correlation between calprotectin and MDA was not statistically significant (P = 0.08). Conclusions: The findings suggest that increased calprotectin is associated with preeclampsia. Further study is necessary in order to determine whether or not high calprotectin levels prevent oxidation of circulating LDL in preeclampsia cases.

Özet

Aim: To evaluate the relationship between serum calprotectin and oxidized low density lipoprotein (LDL) in preeclamptic patients. Additionally, we aimed to measure serum malondialdehyde (MDA) levels as an oxidative stress marker. Materials and Methods: Serum calprotectin, oxidized LDL, and MDA levels were measured in a cross-sectional study of 61 preeclamptic patients (39 severe preeclampsia and 22 mild preeclampsia cases) and 20 healthy pregnant subjects. Serum MDA concentration was measured with spectrophotometric methods, and oxidized LDL and calprotectin were measured via enzyme-linked immunoassay (ELISA). Results: Serum calprotectin (P < 0.0001 and P = 0.014) and MDA (P = 0.001 and P = 0.028) levels were significantly higher in the severe and mild preeclampsia groups than in the healthy control group. Serum oxidized LDL concentration was slightly higher, but not did reach a statistically significant level, in the severe preeclampsia group than in the healthy pregnant group (P = 0.2). There was a significant negative correlation between the levels of calprotectin and oxidized LDL (r = -0.34, P = 0.006) in the mild and severe preeclampsia groups. The correlation between calprotectin and MDA was not statistically significant (P = 0.08). Conclusions: The findings suggest that increased calprotectin is associated with preeclampsia. Further study is necessary in order to determine whether or not high calprotectin levels prevent oxidation of circulating LDL in preeclampsia cases.

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Cite This Article

KADANALI, S., BÖREKÇİ, B., AKSOY, H., ÖZTÜRK, N. (2022). Correlation between Calprotectin and Oxidized LDL in Preeclampsia. Turkish Journal of Medical Sciences, Cilt: 39 - Sayı: 2, 191–195. https://ajindex.com/articles/611673

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References (13)

  1. Sibai BM. Preeclampsia as a cause of preterm and late preterm (near-term) births. Semin Perinatol 2006; 30: 16-9
  2. Luppi P, Haluszczak C, Betters D, Richard CA, Trucco M, DeLoia JA. Monocytes are progressively activated in the circulation of pregnant women. J Leukoc Biol 2002; 72: 874-84
  3. Luppi P, Deloia JA. Monocytes of preeclamptic women spontaneously synthesize pro-inflammatory cytokines. Clin Immunol 2006; 118: 268-75
  4. Williams MA, Woelk GB, King IB, Jenkins L, Mahomed K. Plasma carotenoids, retinol, tocopherols and lipoproteins in preeclamptic and normotensive pregnant Zimbabwean woman Am J Hypertens 2003; 16: 665-72
  5. Ware-Jauregui S, Sanchez SE, Zhang C, Laraburre G, King IB, Williams MA. Plasma lipid concentrations in pre-eclampsia and normotensive Peruvian women. Int J Gynecol Obstet 1999; 67: 147-55 6. Sagol S, Özkınay E, Özsener S. Impaired antioxidant activity in women with pre-eclampsia Int J Gynecol Obstet 1999; 64: 121- 7
  6. Kim YJ, Park H, Lee HY, Ahn YM, Ha EH, Suh SH et al. Paraoxonase gene polymorphism, serum lipid, and oxidized lowdensity lipoprotein in preeclampsia. Eur J Obstet Gynecol Reprod Biol 2007; 133: 47-52
  7. Uzun H, Benian A, Madazli R, Topçuo lu MA, Aydin S, Albayrak M. Circulating oxidized low-density lipoprotein and paraoxonase activity in preeclampsia. Gynecol Obstet Invest 2005; 60: 195- 200
  8. Belo L, Santos-Silva A, Caslake M, Pereira-Leite L, Quintanilha A, Rebelo I. Oxidized-LDL levels in normal and pre-eclamptic pregnancies: contribution of LDL particle size. Atherosclerosis 2005; 183: 185-6
  9. Raijmakers MT, van Tits BJ, Hak-Lemmers HL, Roes EM, Steegers EA, Peters WH. Low plasma levels of oxidized low density lipoprotein in preeclampsia. Acta Obstet Gynecol Scand 2004; 83: 1173-7
  10. Paternoster DM, Fantinato S, Stella A, Nanhornguè KN, Milani M, Plebani M et al. C-reactive protein in hypertensive disorders in pregnancy. Clin Appl Thromb Hemost 2006; 12: 330-37
  11. Bunn SK, Bisset WM, Main MJ, Golden BE. Fecal calprotectin as a measure of disease activity in childhood inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2001; 32: 171-77
  12. Braekke K, Holthe MR, Harsem NK, Fagerhol MK, Staff AC. Calprotectin, a marker of inflammation, is elevated in the maternal but not in the fetal circulation in preeclampsia. Am J Obstet Gynecol 2005; 193: 227-33
  13. Holthe MR, Staff AC, Berge LN, Fagerhol MK, Lyberg T. Calprotectin plasma level is elevated in preeclampsia. Acta Obstet Gynecol Scand 200