Journals / Jinekoloji ve Obstetrik Derg. / 2006 / Cilt: 20 - Sayı: 1

Doppler flow changes in oxytocin versus prostaglandin E1-induced active labor

Oksitosin ve prostaglandin E1 ile yapılan aktif doğum indüksiyonunda doppler akım değişikliklerinin karşılaştırılması

Pages
52–58
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The high degree of S/D ratio in the umbilical artery before induction may be indicating the increased risk of caesarean section.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:OBJECTIVE: The aim of this prospective study is to compare the effect of oxytocin versus misoprostol on Doppler resistance indices of the uterine and umbilical artery during labor induction.STUDY DESIGN: Seventy pregnant women with indications for induction of labor assigned to receive either intravenous oxytocin or misoprostol 50 µg per vagina every 6 h as needed.
📊
Key Findings & Data:These indices in evaluation of the uterine arteries were significantly increased in latent phase compared with those measured before labor induction with oxytocin or misoprostol.
💡
Conclusion & Impact:The high degree of S/D ratio in the umbilical artery before induction may be indicating the increased risk of caesarean section.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: The aim of this prospective study is to compare the effect of oxytocin versus misoprostol on Doppler resistance indices of the uterine and umbilical artery during labor induction.STUDY DESIGN: Seventy pregnant women with indications for induction of labor assigned to receive either intravenous oxytocin or misoprostol 50 µg per vagina every 6 h as needed. Doppler velocimetry of umbilical and bilateral uterine arteries were performed before and three hours after administration of oxytocin or misoprostol and in active phase of labor. In these arteries, pulsatility index (PI), resistance index (RI) and systolic/diastolic ratios (S/D) were measured.RESULTS: Demographic data of the two groups were comparable. In the latent and active phase of labor, PI, RI and S/D ratios in the umbilical artery were not change. These indices in evaluation of the uterine arteries were significantly increased in latent phase compared with those measured before labor induction with oxytocin or misoprostol. There were no significant changes of PI, RI and S/D ratios of all arteries between latent and active phase of labor. The measured values of Doppler parameters of uterine arteries in misoprostol group were significantly higher than those in oxytocin group during the active phase, but they were similar in evaluation of the umbilical artery. Significant positive linear correlation was observed between high S/D ratio in the umbilical artery before induction and the increased risk of caesarean section (r=0.282, p< 0.05).CONCLUSION: Uteroplacental resistance increases in labor induction with oxytocin or misoprostol, but umbilical circulation is not affected. The high degree of S/D ratio in the umbilical artery before induction may be indicating the increased risk of caesarean section.

Özet

AMAÇ: Bu prospektif çalışmanın amacı, oksitosin ve misoprostolle yapılan doğum indüksiyonunda, uterin ve umblikal arter doppler akım direnci belirteçlerini karşılaştırmaktır.MATERYAL ve METOD: Doğum indüksiyonu için endikasyon koyulan 70 gebe kadına intravenöz oksitosin veya gerektikçe 6 saatte bir 50 µg vajinal olarak misoprostol verildi. Uterin ve umblikal arterlerin doppler değerlendirmesi indüksiyon öncesi, indüksiyondan 3 saat sonra (latent faz) ve aktif fazlarda yapıldı. Bu arterlerde pulsatilite indeksi (PI), rezistans indeksi (RI) ve sistol/diastol (S/D) oranı ölçüldü.BULGULAR: İki grubun demografik özellikleri benzerdi. Uterin arterlerin incelemesinde, doğumun latent ve aktif fazlarında umblikal arter PI, RI ve S/D oranları değişmedi. Bu belirteçler latent fazda, oksitosin ve misoprostol ile doğum indüksiyonuna başlamadan önceki ölçüme göre belirgin artış gösterdi. Doğumun latent ve aktif fazları arasında tüm arterlerde PI, RI ve S/D oranı açısından önemli bir değişiklik görülmedi. Aktif fazda uterin arterde ölçülen doppler parametreleri misoprostol grubunda oksitosin grubunda ölçülenlere göre önemli derecede yüksekti, fakat umblikal arter ölçümleri benzerdi. İndüksiyon öncesi dönemde umblikal arterde tespit edilen yüksek S/D oranı ile artmış sezaryen riski arasında pozitif lineer ilişki görüldü (r=0.282, p< 0.05).SONUÇ: Oksitosin veya misoprostol ile yapılan doğum indüksiyonu uteroplasental direnç artışına yol açar, fakat umblikal dolaşım bundan etkilenmez. İndüksiyon öncesi tespit edilen yüksek S/D oranı artmış sezaryen riskini gösterebilir.

🔖

Cite This Article

KADANALI, S., İNGEÇ, M., KUMTEPE, Y., BÖREKÇİ, B., BIKMAZ, H. Ş. (2022). Doppler flow changes in oxytocin versus prostaglandin E1-induced active labor. Jinekoloji ve Obstetrik Derg., Cilt: 20 - Sayı: 1, 52–58. https://ajindex.com/articles/559020

References (13)

  1. Hofstaetter C, Dubiel M, Gudmundsson S, Marsal K: Uterine artery color Doppler assisted velocimetry and perinatal outcome. Acta Obstet Gynecol Scand 75:612, 1996. 2. van Asselt K, Gudmundsson S, Lindqvist P, Marsal K: Uterine and umbilical artery velocimetry in pre-eclampsia. Acta Obstet Gynecol Scand 77:614, 1998
  2. Audibert F, Benchimol Y, Benattar C, Champagne C, Frydman R: Prediction of preeclampsia or intrauterine growth restriction by second trimester serum screening and uterine Doppler velocimetry. Fetal Diagn Ther 20:48, 2005
  3. Schwarze A, Nelles I, Krapp M, Friedrich M, Schmidt W, Diedrich K, Axt-Fliedner R: Doppler ultrasound of the uterine artery in the prediction of severe complications during low-risk pregnancies. Arch Gynecol Obstet 271:46, 2005
  4. Anastasiadis P, Avgidou K, Anastasiadis AN, Kotini A, Ko-utlaki N, Anninos P: Correlation between biomagnetic and Doppler findings of the uterine artery in normal and preeclamptic pregnancies. Prenat Diagn 25:51, 2005
  5. Yagel S, Anteby E, Lavy Y, Ben Chetrit A, Palti Z, Hoch-ner-Celnikier D, Ron M: Fetal middle cerebral artery blood flow during normal active labour and in labour with variable decelerations. Br J Obstet Gynaecol 99:483, 1992
  6. Somerset DA, Murrills AJ, Wheeler T: Screening for fetal distress in labour using the umbilical artery blood velocity waveform. Br J Obstet Gynaecol 100:55, 1993
  7. Doherty DA, James IR, Newnham JP: Estimation of the Doppler ultrasound umbilical maximal waveform envelope: II. Prediction of fetal distress. Ultrasound Med Biol 28:1261, 2002
  8. Kadanali S, Kucukozkan T, Zor N, Kumtepe Y: Comparison of labor induction with misoprostol vs. oxytocin/prostaglandin E2 in term pregnancy. Int J Gynaecol Obstet 55:99, 1996
  9. Pongsatha S, Vijittrawiwat A, Tongsong T: A comparison of labor induction by oral and vaginal misoprostol. Int J Gynaecol Obstet 88:140, 2005
  10. Kipikasa JH, Adair CD, Williamson J, Breen JM, Medford LK, Sanchez-Ramos L: Use of misoprostol on an outpatient basis for postdate pregnancy. Int J Gynaecol Obstet 88:108, 2005
  11. Sanchez-Ramos L, Kaunitz AM, Wears RL, Delke I, Gaudier FL: Misoprostol for cervical ripening and labor induction: a meta-analysis. Obstet Gynecol 89:633, 1997
  12. Farah LA, Sanchez-Ramos L, Rosa C, Del Valle GO, Gaudier FL, Delke I, Kaunitz AM: Randomized trial of two doses of the prostaglandin El analog misoprostol for labor induction. Am J Obstet Gynecol 177:364, 1997
  13. Gonzalez CH, Marques-Dias MJ, Kim C