SavedAdd your journal

Journals / Turkish Journal of Medical Sciences / 2012 / Cilt: 42 - Sayı: 3

Prevalence of latent prostate cancer and prostatic intraepithelial neoplasia in İstanbul, Turkey: an autopsy study

İbrahim UZUN
İlhan GEÇİT
Gülay KURNAZ
Nusret AKPOLAT
Yalçın BÜYÜK
Pages
449–456
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In order to determine latent PCa cases, males over 40 years of age must be screened more strictly.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:To investigate the frequency of latent prostatic carcinoma (PCa) and prostatic intraepithelial neoplasia (PIN) in the Turkish population.
📊
Key Findings & Data:Materials and methods: PCa and PIN were evaluated in 116 male autopsy cases in which the cause of death was nontumoral.
💡
Conclusion & Impact:In order to determine latent PCa cases, males over 40 years of age must be screened more strictly.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Key words: Prostate cancer · prostatic intraepithelial neoplasia · prevalence

Abstract

To investigate the frequency of latent prostatic carcinoma (PCa) and prostatic intraepithelial neoplasia (PIN) in the Turkish population. Materials and methods: PCa and PIN were evaluated in 116 male autopsy cases in which the cause of death was nontumoral. All patients were Turkish, living in İstanbul, and aged 40-79 years. Results: The prevalence of PCa was 19.8% and the decade rates (decades 5-8) were 9.5%, 12.5%, 18.8%, and 37%, respectively (P < 0.011). The rates of high-grade prostatic intraepithelial neoplasia (HGPIN) were 33.3%, 31.3%, 56.3%, and 25.9% for decades 5-8, respectively (P > 0.05). A total of 68.4% of PCa cases were HGPIN. There was a statistically significant correlation among HGPIN, PCa, and Gleason scores (P < 0.002). Conclusion: The prevalence of latent PCa in the Turkish population is very high (19.7%). In order to determine latent PCa cases, males over 40 years of age must be screened more strictly.

Özet

To investigate the frequency of latent prostatic carcinoma (PCa) and prostatic intraepithelial neoplasia (PIN) in the Turkish population. Materials and methods: PCa and PIN were evaluated in 116 male autopsy cases in which the cause of death was nontumoral. All patients were Turkish, living in İstanbul, and aged 40-79 years. Results: The prevalence of PCa was 19.8% and the decade rates (decades 5-8) were 9.5%, 12.5%, 18.8%, and 37%, respectively (P < 0.011). The rates of high-grade prostatic intraepithelial neoplasia (HGPIN) were 33.3%, 31.3%, 56.3%, and 25.9% for decades 5-8, respectively (P > 0.05). A total of 68.4% of PCa cases were HGPIN. There was a statistically significant correlation among HGPIN, PCa, and Gleason scores (P < 0.002). Conclusion: The prevalence of latent PCa in the Turkish population is very high (19.7%). In order to determine latent PCa cases, males over 40 years of age must be screened more strictly.

🔖

Cite This Article

UZUN, İ., GEÇİT, İ., KURNAZ, G., AKPOLAT, N., BÜYÜK, Y. (2022). Prevalence of latent prostate cancer and prostatic intraepithelial neoplasia in İstanbul, Turkey: an autopsy study. Turkish Journal of Medical Sciences, Cilt: 42 - Sayı: 3, 449–456. https://ajindex.com/articles/611260

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Grönberg H. Prostate cancer epidemiology. Lancet 2003; 361: 859-64. 2. La Rosa F, Stracci F, Minelli L, Mastrandrea V. Epidemiology of prostate cancer in the Umbria region of Italy: evidence of opportunistic screening eff ects. Urol 2003; 62: 1040-4. 3. Farkas A, Schneider D, Perrotti M, Cummings KB, Ward WS. National trends in the epidemiology of prostate cancer, 1973 to 1994: evidence for the eff ectiveness of prostate-specifi c antigen screening. Urol 1998; 52: 444-9. 4. Crawford ED. Epidemiology of prostate cancer. Urol 2003; 62: 3-12.
  2. Sakr WA, Grignon DJ, Haas GP, Schomer KL, Heilbrun LK, Cassin BJ et al. Epidemiology of high-grade prostatic intraepithelial neoplasia. Pathol Res Pract 1995; 191: 838-41.
  3. Sakr WA, Grignon DJ, Crissman JD, Heilbrun LK, Cassin BJ, Pontes JJ et al. High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: an autopsy study of 249 cases. In Vivo 1994; 8: 439-43.
  4. Sakr WA, Grignon DJ, Haas GP, Heilbrun LK, Pontes JE, Crissman JD. Age and racial distribution of prostatic intraepithelial neoplasia. Eur Urol 1996; 30: 138-44. Bostwick DG. Prostatic intraepithelial neoplasia. Curr Urol Rep 2000; 1: 65-70.
  5. Sanchez-Chapado M, Olmedilla G, Cabeza M, Donat E, Ruiz A. Prevalence of prostate cancer and prostatic intraepithelial neoplasia in Caucasian Mediterranean males: an autopsy study. Th e Prostate 2003; 54: 238-47.
  6. Stemmermann GN, Nomura AM, Chyou PH, Yatani R. A prospective comparison of prostate cancer at autopsy and as a clinical event: the Hawaii Japanese experience. Cancer Epidemiol Biomarkers Prev 1992; 1: 189-93. Gatling RR. Prostate carcinoma: an autopsy evaluation of the infl uence of age, tumor grade, and therapy on tumor biology. South Med J 1990; 83: 782-4. Billis A. Latent carcinoma and atypical lesions of prostate. An autopsy study. Urol 1986; 28: 324-9.
  7. Breslow N, Chan CW, Dhom G, Drury RA, Franks LM, Gellei B et al. Latent carcinoma of prostate at autopsy in seven areas. Collaborative study organized by the International Agency for Research on Cancer, Lyons, France. Int J Cancer 1977; 20: 680- 8. Montie JE, Wood DP Jr, Pontes JE, Boyett JM, Levin HS. Adenocarcinoma of the prostate in cystoprostatectomy specimens removed for bladder cancer. Cancer 1989; 63: 381-5.
  8. Moutzouris G, Barbatis C, Plastiras D, Mertziotis N, Katsifotis C, Presvelos V et al. Incidence and histological fi ndings of unsuspected prostatic adenocarcinoma in radical cystoprostatectomy for transit