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Journals / Turkish Journal of Medical Sciences / 2014 / Cilt: 44 - Sayı: 2

Anti TNF-α therapy might be responsible for an increased incidence of varicocele in patients with ankylosing spondylitis

Mahmut YENER
Mehmet UMUL
Elif Nisa ÜNLÜ
Yunus UGAN
Meltem ÇETİN
Bumin DEĞİRMENCİ
Bünyamin KISACIK
Mustafa KAYAN
Aykut Recep AKTAŞ
Ömer YILMAZ
Pages
311–316
Publication Date
2022-11-05
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The present study shows that patients with AS who were taking anti-TNF-α therapy had an increased prevalence of rightsided and bilateral varicocele compared to patients with AS who were not taking any disease-modifying antirheumatic drugs and the healthy control group.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: To evaluate the effects of anti-tumor necrosis factor-alpha (TNF-α) therapy on the frequency of varicocele in patients with ankylosing spondylitis (AS) using color Doppler ultrasound.
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Key Findings & Data:Materials and methods: The patients were divided into 2 groups: patients with AS who were on anti-TNF-α treatment and patients with AS who were not regularly taking any antiinflammatory drugs.
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Conclusion & Impact:Conclusion: The present study shows that patients with AS who were taking anti-TNF-α therapy had an increased prevalence of rightsided and bilateral varicocele compared to patients with AS who were not taking any disease-modifying antirheumatic drugs and the healthy control group.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: To evaluate the effects of anti-tumor necrosis factor-alpha (TNF-α) therapy on the frequency of varicocele in patients with ankylosing spondylitis (AS) using color Doppler ultrasound. Materials and methods: The patients were divided into 2 groups: patients with AS who were on anti-TNF-α treatment and patients with AS who were not regularly taking any antiinflammatory drugs. Thirty-one healthy volunteers were included as controls. Results: Left-sided varicocele was determined in 14 patients of Group 1 (44%), 10 patients of Group 2 (33%), and 7 of the controls (23%). There was a statistically significant difference only between Group 1 and controls (P = 0.009). However, right-sided varicocele was determined in 12 patients of Group 1 (38%), 2 patients of Group 2 (6%), and 2 of the controls (6%) (P = 0.01 vs. Group 2, P = 0.005 vs. controls). Conclusion: The present study shows that patients with AS who were taking anti-TNF-α therapy had an increased prevalence of rightsided and bilateral varicocele compared to patients with AS who were not taking any disease-modifying antirheumatic drugs and the healthy control group.

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Cite This Article

YENER, M., UMUL, M., ÜNLÜ, E. N., UGAN, Y., ÇETİN, M., DEĞİRMENCİ, B., KISACIK, B., KAYAN, M., AKTAŞ, A. R., YILMAZ, Ö. (2022). Anti TNF-α therapy might be responsible for an increased incidence of varicocele in patients with ankylosing spondylitis. Turkish Journal of Medical Sciences, Cilt: 44 - Sayı: 2, 311–316. https://ajindex.com/articles/610990

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