SavedAdd your journal

Journals / Turkish Journal of Medical Sciences / 2014 / Cilt: 44 - Sayı: 3

The expression of EGFR, cerbB2, p16, and p53 and their relationship with conventional parameters in squamous cell carcinoma of the larynx*

Binnur ÖNAL
Hülya ŞİMŞEK
Ünsal HAN
Gülçin ŞİMŞEK
Pages
411–416
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In comparison with p53 and p16 expression levels, EGFR and cerbB2 expression levels were observed to be associated with poor prognostic parameters and were higher at later stages of laryngeal carcinogenesis development.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aim: To investigate the expression of epidermal growth factor receptor¬-HER1 (EGFR), cerbB2 (HER2), p16, and p53, as well as the relationship of the expression of these genes with conventional parameters in squamous cell carcinoma (SCC) of the larynx.
📊
Key Findings & Data:Materials and methods: Samples from 92 cases of diagnosed laryngeal SCC between 2001 and 2011 from the Pathology Department of Ministry of Health Ankara Dışkapı Yıldırım Beyazıt Teaching & Research Hospital were studied by immunohistochemistry using EGFR, cerbB2, p16, and p53 antibodies.
💡
Conclusion & Impact:In comparison with p53 and p16 expression levels, EGFR and cerbB2 expression levels were observed to be associated with poor prognostic parameters and were higher at later stages of laryngeal carcinogenesis development.
🔬Design:Research Article
📍Scope:2001 Verileri
⚙️Variables:Domain Parameters

Abstract

Background/aim: To investigate the expression of epidermal growth factor receptor¬-HER1 (EGFR), cerbB2 (HER2), p16, and p53, as well as the relationship of the expression of these genes with conventional parameters in squamous cell carcinoma (SCC) of the larynx. Materials and methods: Samples from 92 cases of diagnosed laryngeal SCC between 2001 and 2011 from the Pathology Department of Ministry of Health Ankara Dışkapı Yıldırım Beyazıt Teaching & Research Hospital were studied by immunohistochemistry using EGFR, cerbB2, p16, and p53 antibodies. Results: An increase in the TNM stage and pathological tumor size status correlated with an increase in EGFR and cerbB2 expression. In the cases with lymphovascular invasion, the expression was detected at a higher ratio. Cases in which high levels of p16 and p53 expression were observed did not show any lymphovascular invasions. Conclusion: Expressions of p53 and p16 were considered to be most effective in early carcinogenesis stages of laryngeal SCC. In comparison with p53 and p16 expression levels, EGFR and cerbB2 expression levels were observed to be associated with poor prognostic parameters and were higher at later stages of laryngeal carcinogenesis development.

🔖

Cite This Article

ÖNAL, B., ŞİMŞEK, H., HAN, Ü., ŞİMŞEK, G. (2022). The expression of EGFR, cerbB2, p16, and p53 and their relationship with conventional parameters in squamous cell carcinoma of the larynx*. Turkish Journal of Medical Sciences, Cilt: 44 - Sayı: 3, 411–416. https://ajindex.com/articles/610977

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Robbins SL, Kumar V, Cotran RS. Robbins and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia, PA, USA: Saunders/Elsevier; 2010
  2. Thompson L. World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Ear Nose Throat J 2006; 85: 74
  3. Rosai J, Ackerman LV. Rosai and Ackerman’s Surgical Pathology. 9th ed. Edinburgh, UK: Mosby; 2004
  4. Cardesa A, Slootweg PJ. Pathology of the Head and Neck. Berlin, Germany: Springer; 2006
  5. Pilch BZ. Head and Neck Surgical Pathology. Philadelphia, PA, USA: Lippincott Williams & Wilkins; 2001
  6. Sternberg SS, Mills SE, Carter D. Sternberg’s Diagnostic Surgical Pathology. 4th ed. Philadelphia, PA, USA: Lippincott Williams & Wilkins; 2004
  7. Sternberg SS. Histology for Pathologists. 2nd ed. Philadelphia, PA, USA: Lippincott-Raven; 1997
  8. Kocaturk S, Yilmazer D, Onal B, Erkam U, Urunal B. Do micrometastases detected with cytokeratin immunoperoxidase reactivity affect the treatment approach to neck in supraglottic cancers? Otolaryngol Head Neck Surg 2003; 128: 407–411
  9. Moore KL. Clinically Oriented Anatomy. 3rd ed. Baltimore, MD, USA: Williams & Wilkins; 1992
  10. Şimşek G, Han Ü, Önal B, Koybaşıoğlu F, Akın İ, Dağlı M. Expression of cyclin D1, p27, p21, BCL-2 and p53 in laryngeal squamous cell carcinoma and investigation of correlation with conventional prognostic factors. Turk J Med Sci 2013; 43: 27–32
  11. Arıncı K, Elhan A. Anatomi. Ankara, Turkey: Güneş Tıp Kitabevi; 2006
  12. Chomchai JS, Du W, Sarkar FH, Li YW, Jacobs JR, Ensley JF, Sakr W, Yoo GH. Prognostic significance of p53 gene mutations in laryngeal cancer. Laryngoscope 1999; 109: 455–459
  13. Sun J, Xiong J, Zhen Y, Chen ZL, Zhang H. P53 and PCNA is positively correlated with HPV infection in laryngeal epitheliopapillomatous lesions in patients with different ethnic backgrounds in Xinjiang. Asian Pac J Cancer Prev 2012; 13: 5439–5444
  14. Koynova DK, Tsenova VS, Jankova RS, Gurov PB, Toncheva DI. Tissue microarray analysis of EGFR and HER2 oncogene copy number alterations in squamous cell carcinoma of the larynx. J Cancer Res Clin Oncol 2005; 131: 199–203
  15. Micozkadioğlu D, Unal M, Pata YS, Baştürk M, Cinel L. Prognostic value of expression of p53, proliferating cell nuclear antigen, and c-erbB-2 in laryngeal carcinoma. Med Sci Monit 2008; 14: CR299–304
  16. Brunner K, Fischer CA, Driemel O, Hartmann A, Brockhoff G, Schwarz S. EGFR (HER) family protein expression and cytogenetics in 219 squamous