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Journals / Turkish Journal of Medical Sciences / 2016 / Cilt: 46 - Sayı: 4

Coexistence of preeclampsia and inherited thrombophilia in Turkish pregnant women

İsmail GÜLER
Mehtap POLAT
Ebru Hacer BİBEROĞLU
Ömer Kutay BİBEROĞLU
Pages
1094–1100
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Furthermore, copper is selectively elevated in women with PE as an independent marker.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/aim: To examine the relationship of inherited thrombophilia and other thrombotic risk factors with preeclampsia (PE) in a population of pregnant Turkish women.
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Key Findings & Data:Materials and methods: This was a case cross-sectional study in which 70 women with PE and 60 normal pregnant women were studied to find out the frequency of women with risk factors including inherited thrombophilia among preeclamptic cases.
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Conclusion & Impact:Furthermore, copper is selectively elevated in women with PE as an independent marker.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: To examine the relationship of inherited thrombophilia and other thrombotic risk factors with preeclampsia (PE) in a population of pregnant Turkish women. Materials and methods: This was a case cross-sectional study in which 70 women with PE and 60 normal pregnant women were studied to find out the frequency of women with risk factors including inherited thrombophilia among preeclamptic cases. Results: Hemoglobin, platelet count, uric acid, vitamin B12, folic acid, copper, homocysteine, plasminogen activator inhibitor-1, fibrinogen, protein S, protein C, activated protein C resistance values show significant differences in women with PE in comparison to women with normal pregnancy. Conclusion: There may be a link between inherited thrombophilia and PE, at least in a sample of Turkish pregnant women. We also propose that the association between thrombophilia and PE is stronger than suggested previously. Furthermore, copper is selectively elevated in women with PE as an independent marker.

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Cite This Article

GÜLER, İ., POLAT, M., BİBEROĞLU, E. H., BİBEROĞLU, Ö. K. (2022). Coexistence of preeclampsia and inherited thrombophilia in Turkish pregnant women. Turkish Journal of Medical Sciences, Cilt: 46 - Sayı: 4, 1094–1100. https://ajindex.com/articles/610662

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References (12)

  1. Lykke JA, Bare LA, Olsen J, Lagier R, Arellano AR, Tong C, Paidas MJ, Langhoof-Roos J. Thrombophilias and adverse pregnancy outcomes: results from the Danish National Birth Cohort. J Thromb Haemost 2012; 10: 1320-1325
  2. Reyes LM, García RG, Ruiz SL, Camacho PA, Ospina MB, Aroca G, Accini JL, López-Jaramillo P. Risk factors for preeclampsia in women from Colombia: a case-control study. PLoS One 2012; 7: e41622
  3. Kupferminc MJ, Fait G, Many A, Gordon D, Eldor A, Lessing JB. Severe preeclampsia and high frequency of genetic thrombophilic mutations. Obstet Gynecol 2000; 96: 45-49
  4. Livingston JC, Barton JR, Park V, Haddad B, Phillips O, Sibai BM. Maternal and fetal inherited thrombophilias are not related to the development of severe preeclampsia. Am J Obstet Gynecol 2001; 185: 153-157
  5. Kahn SR, Platt R, McNamara H, Rozen R, Chen MF, Genest J Jr, Goulet L, Lydon J, Seguin L, Dassa C et al. Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study. Am J Obstet Gynecol 2009; 200: 151.e1-151.e9
  6. Rodger MA, Betancourt MT, Clark P, Lindqvist PG, DizonTownson D, Said J, Seligsohn U, Carrier M, Solomon O, Greer IA. The association of factor V Leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies. PLoS Med 2010; 7: e1000292
  7. Rasmussen A, Ravn P. High frequency of congenital thrombophilia in women with pathological pregnancies? Acta Obstet Gynecol Scand 2004; 83: 808-817
  8. Kist WJ, Janssen NG, Kalk JJ, Hague WM, Dekker GA, de Vries JI. Thrombophilias and adverse pregnancy outcome - A confounded problem! Thromb Haemost 2008; 99: 77-85
  9. Katz O, Paz-Tal O, Lazer T, Aricha-Tamir B, Mazor M, Wiznitzer A, Sheiner E. Severe preeclampsia is associated with abnormal trace elements concentrations in maternal and fetal blood. J Matern Fetal Neonatal Med 2012; 25: 1127-1130
  10. Fenzl V, Flegar-Meštrić Z, Perkov S, Andrišić L, Tatzber F, Žarković N, Duić Ž. Trace elements and oxidative stress in hypertensive disorders of pregnancy. Arch Gynecol Obstet 2013; 287: 19-24
  11. Sarwar MD, Ahmed S, Ullah MS, Kabir H, Rahman GKM, Safiqul Islam HAM. Comparative study of serum zinc, copper, manganese, and iron in preeclamptic pregnant women. Biol Trace Elem Res 2013; 154: 14-20
  12. Ohkuchi A, Iwasaki R, Suzuki H, Hirashima C, Takahashi K, Usui R, Matsubara S, Minakami H, Suzuki M. Normal and high-normal blood pressures, but no