AI Summary & Key Takeaways
AI InsightMN scoring may be a helpful diagnostic tool for distinguishing malignanteffusions from benign ones, and may be used as an adjunct tool to predict malignant behavior in challenging cases.
📌 3 Key Takeaways
Abstract
Background/aim: Micronucleus (MN) frequency is used as a biomarker of chromosomal damage, genome instability, and cancer risk.The aim of this study was to evaluate the diagnostic usefulness of MN frequency to differentiate between malignant and benign pleuraleffusion samples.Materials and methods: Retrospectively, 78 pleural fluid cytology samples (including 20 cases of benign reactive mesothelial cells, 22cases of suspicious cytology, and 36 cases of malignant cytology) were examined. The number of micronucleated cells in 1000 wellpreserved cells was counted. Statistical tests were performed to compare the study groups. Recover operating characteristics (ROC)curve analysis was performed to suggest a cut-off value for predicting malignant behavior.Results: We evaluated a total of 78 cases of pleural effusion cytology. The number of micronucleated cells was significantly higher incases with malignant outcome compared to cases with benign outcome. We observed that malignant samples had more micronucleatedcells than suspicious ones, and suspicious cases had more micronucleated cells than reactive ones. There was a significant differenceamong all study groups. In addition, the frequency of MN-containing cells in suspicious cases correlates well with their outcomes.Conclusion: The results of this study reveal that there is an absolute, consistent, and proportional relationship between MN countsand malignancy in cytological samples of pleural effusions. MN scoring may be a helpful diagnostic tool for distinguishing malignanteffusions from benign ones, and may be used as an adjunct tool to predict malignant behavior in challenging cases.