The AR group had a higher NLR compared to thecontrols (P 2.5) are associated with AR in kidney transplant patients, leading to theconclusion that NLR might be an easily available and useful marker option for detection of AR in this patient population.
📌 3 Key Takeaways
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Objective & Hypothesis:Background/aim: Our research focused on the identification of easily available and sensitive markers for early prediction of acutekidney allograft rejection (AR).
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Key Findings & Data:We aimed to investigate the association between neutrophil-to-lymphocyte ratio (NLR) and AR inkidney transplant patients.Materials and methods: The medical records of 51 kidney transplant patients [12 female/39 male; median age of 32 (IQR: 24–44) years]were evaluated retrospectively.
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Conclusion & Impact:The AR group had a higher NLR compared to thecontrols (P 2.5) are associated with AR in kidney transplant patients, leading to theconclusion that NLR might be an easily available and useful marker option for detection of AR in this patient population.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Background/aim: Our research focused on the identification of easily available and sensitive markers for early prediction of acutekidney allograft rejection (AR). We aimed to investigate the association between neutrophil-to-lymphocyte ratio (NLR) and AR inkidney transplant patients.Materials and methods: The medical records of 51 kidney transplant patients [12 female/39 male; median age of 32 (IQR: 24–44) years]were evaluated retrospectively. We considered a cut-off value of >2.5 as high NLR.Results: A total of 22 biopsy-proven AR patients and 29 controls were evaluated. The AR group had a higher NLR compared to thecontrols (P 2.5) are associated with AR in kidney transplant patients, leading to theconclusion that NLR might be an easily available and useful marker option for detection of AR in this patient population.
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Cite This Article
DERİCİ, Ü., KÖPRÜ, B., DEĞER, S. M., ERGİN, G., ARINSOY, T. (2022). High neutrophil-to-lymphocyte ratio predicts acute allograft rejection in kidney transplantation: a retrospective study. Turkish Journal of Medical Sciences, Cilt: 49 - Sayı: 2, 525–530. https://ajindex.com/articles/610126
Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LY et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 1999; 341: 1725-1730
Rabbat CG, Thorpe KE, Russell JD, Churchill DN. Comparison of mortality risk for dialysis patients and cadaveric first renal transplant recipients in Ontario, Canada. J Am Soc Nephrol 2000; 11: 917-922
Shrestha BM, Haylor JL. Factors influencing long-term outcomes following renal transplantation: a review. J Nepal Med Assoc 2007; 46: 136-142
Norin AJ, Mondragon-Escorpizo MO, Brar A, Hochman D, Sumrani N, Distant DA et al. Poor kidney allograft survival associated with positive B cell - Only flow cytometry cross matches: a ten year single center study. Hum Immunol 2013; 74: 1304-1312
Bobb GA, Fairchild EJ. Neutrophil-to-lymphocyte ratio as indicator of ozone exposure. Toxicol Appl Pharmacol 1967; 11: 558-564
Hung HY, Chen JS, Yeh CY, Changchien CR, Tang R, Hsieh PS et al. Effect of preoperative neutrophil-lymphocyte ratio on the surgical outcomes of stage II colon cancer patients who do not receive adjuvant chemotherapy. Int J Colorectal Dis 2011; 26: 1059-1065
Kim HS, Han KH, Chung HH, Kim JW, Park NH, Song YS et al. Neutrophil to lymphocyte ratio for preoperative diagnosis of uterine sarcomas: a case-matched comparison. Eur J Surg Oncol 2010; 36: 691-698
Dong CH, Wang ZM, Chen SY. Neutrophil to lymphocyte ratio predict mortality and major adverse cardiac events in acute coronary syndrome: a systematic review and meta-analysis. Clin Biochem 2018; 52: 131-136
Gul U, Kayani AM, Munir R, Hussain S. Neutrophil lymphocyte ratio: a prognostic marker in acute ST elevation myocardial infarction. J Coll Physicians Surg Pak 2017; 27: 4-7
Argan O, Ural D, Kozdag G, Sahin T, Bozyel S, Aktas M et al. Associations between neutrophil gelatinase associated lipocalin, neutrophil-to-lymphocyte ratio, atrial fibrillation and renal dysfunction in chronic heart failure. Med Sci Monit 2016; 22: 4765-4772
Ishizuka M, Shimizu T, Kubota K. Neutrophil-to-lymphocyte ratio has a close association with gangrenous appendicitis in patients undergoing appendectomy. Int Surg 2012; 97: 299- 2304
Kahramanca S, Kaya O, Ozgehan G, Irem B, Dural I, Kucukpinar T et al. Are neutrophil-lymphocyte ratio and plateletlymphocyte ratio as effective as Fournier’s gangrene severity index for predicting the