SavedAdd your journal

Journals / Turkish Journal of Medical Sciences / 2019 / Cilt: 49 - Sayı: 5

IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms in patients with chronic rhinosinusitis with sinonasal polyposis

Hüseyin ASLAN
Süheyl HAYTOĞLU
Gökhan KURAN
Özge ÖZALP YÜREĞİR
Sevcan TUĞ BOZDOĞAN
Pages
1411–1417
Publication Date
2022-11-04
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, we analyzed possible genetic factors that increase susceptibility to this widespread inflammatory disease.Materials and methods: A total of 176 adult patients, including 78 patients with sinonasal polyposis and 98 healthy controls, wereanalyzed for IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms using polymerase chain reaction and enzyme restriction.Results: IL-1RN and IL-4 VNTR polymorphisms were notably associated with sinonasal polyposis (P = 0.0001 and P = 0.036,respectively); however, regarding the IL-2(-330) gene polymorphism, no significant difference was shown between the patient andcontrol groups (P = 0.235).Conclusions: Our study indicates that the RN2 allele of IL-1RN and the RP1 allele of IL-4 might be risk factors for developing sinonasalpolyposis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aim: Sinonasal polyposis is a complex chronic disease displaying contributions from multiple genetic and environmentalfactors.
📊
Key Findings & Data:Background/aim: Sinonasal polyposis is a complex chronic disease displaying contributions from multiple genetic and environmentalfactors.
💡
Conclusion & Impact:In this study, we analyzed possible genetic factors that increase susceptibility to this widespread inflammatory disease.Materials and methods: A total of 176 adult patients, including 78 patients with sinonasal polyposis and 98 healthy controls, wereanalyzed for IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms using polymerase chain reaction and enzyme restriction.Results: IL-1RN and IL-4 VNTR polymorphisms were notably associated with sinonasal polyposis (P = 0.0001 and P = 0.036,respectively); however, regarding the IL-2(-330) gene polymorphism, no significant difference was shown between the patient andcontrol groups (P = 0.235).Conclusions: Our study indicates that the RN2 allele of IL-1RN and the RP1 allele of IL-4 might be risk factors for developing sinonasalpolyposis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aim: Sinonasal polyposis is a complex chronic disease displaying contributions from multiple genetic and environmentalfactors. In this study, we analyzed possible genetic factors that increase susceptibility to this widespread inflammatory disease.Materials and methods: A total of 176 adult patients, including 78 patients with sinonasal polyposis and 98 healthy controls, wereanalyzed for IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms using polymerase chain reaction and enzyme restriction.Results: IL-1RN and IL-4 VNTR polymorphisms were notably associated with sinonasal polyposis (P = 0.0001 and P = 0.036,respectively); however, regarding the IL-2(-330) gene polymorphism, no significant difference was shown between the patient andcontrol groups (P = 0.235).Conclusions: Our study indicates that the RN2 allele of IL-1RN and the RP1 allele of IL-4 might be risk factors for developing sinonasalpolyposis.

🔖

Cite This Article

ASLAN, H., HAYTOĞLU, S., KURAN, G., YÜREĞİR, Ö. Ö., BOZDOĞAN, S. T. (2022). IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms in patients with chronic rhinosinusitis with sinonasal polyposis. Turkish Journal of Medical Sciences, Cilt: 49 - Sayı: 5, 1411–1417. https://ajindex.com/articles/610016

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I et al. European position paper on rhinosinusitis and nasal polyps. Rhinology 2012; Mar 50(1): 1-12
  2. Sousa H, Breda E, Santos AM, Catarino R, Pinto D et al. IL1RN VNTR polymorphism as a susceptibility marker for nasopharyngeal carcinoma in Portugal. Archives of Oral Biology 2013; 58(8): 1040-1046
  3. Al-Tahhan M, Etewa RL, El Behery MM. Association between circulating interleukin-1 beta (IL-1b) levels and IL-1b C-511 T polymorphism with cervical cancer risk in Egyptian women. Molecular and Cellular Biochemistry 2011; 353: 159-165
  4. Tarlow JK, Blakemore AI, Lennard A, Solari R, Hughes HN et al. Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Human Genetics 1993; 91: 403-404
  5. Gohlke H, Illig T, Bahnweg M, Klopp N, Andre E, Altmuller J et al. Association of the interleukin-1 receptor antagonist gene with asthma. American Journal of Respiratory Critical Care Medicine 2004; 169(11): 1217-1223
  6. Haukim N, Bidwell JL, Smith AJ, Keen LJ, Gallagher G et al. Cytokine gene polymorphism in human disease: on-line databases. Genes and Immunity 2002; 3(6): 313-330
  7. Paul WE, Seder RA. Lymphocyte responses and cytokines. Cell 1994; 76(2): 241-251
  8. Degrave W, Tavernier J, Duerinck F, Plaetinck G, Devos R et al. Cloning and structure of the human Interleukin 2 chromosomal gene. EMBO Journal 1983; 2(12): 2349-2353
  9. John S, Turner D, Donn R, Sinnott P, Worthington J et al. Two novel biallelic polymorphisms in the IL-2 gene. European Journal of Immunogenetics 1998; 25(6): 419-420
  10. Coffman RL, Ohara J, Bond MW, Carty J, Zlotnik A et al. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. The Journal of Immunology 1986; 136(12): 4538-4541
  11. Del Prete G, Maggi E, Parronchi P, Chretien I, Tiri A et al. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. The Journal of Immunology 1988; 140(12): 4193-4198
  12. Peric A, Vojvodic D, Vukomanovic-Durdevic B, Baletic N. Eosinophilic inflammation in allergic rhinitis and nasal polyposis. Archives of Industrial Hygiene Toxicology 2011; 62(4): 341-348
  13. Kayar NA, Alptekin NÖ, Erdal ME. Interleukin-1 receptor antagonist gene polymorphism, adverse pregnancy outcome and periodontitis in Turkish women. Archives of Oral Biology 2015; 60(12): 1777-1783
  14. Moorchung N, Vasudevan B, Chatterjee M