Journals / Turkish Journal of Medical Sciences / 2021 / Cilt: 51 - Sayı: 5

Clinical characteristics and risk factors for 28-day mortality in critically ill patients with COVID-19: a retrospective cohort study

Pages
2285–2295
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Early detection of the risk factors and the use of chest CT score might improve the outcomes in patients with COVID-19.Key words: COVID-19, critical care, tomography, mortality, risk factors, SARS-CoV-2

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background: To date, the coronavirus disease 2019 (COVID-19) caused more than 2.6 million deaths all around the world.
📊
Key Findings & Data:The primary aim was to determine the independent risk factors for 28-day mortality.
💡
Conclusion & Impact:Conclusion: Early detection of the risk factors and the use of chest CT score might improve the outcomes in patients with COVID-19.Key words: COVID-19, critical care, tomography, mortality, risk factors, SARS-CoV-2
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:Domain Parameters

Abstract

Background: To date, the coronavirus disease 2019 (COVID-19) caused more than 2.6 million deaths all around the world. Risk factors for mortality remain unclear. The primary aim was to determine the independent risk factors for 28-day mortality. Materials and Methods: In this retrospective cohort study, critically ill patients (≥ 18 years) who were admitted to the intensive care unit due to COVID-19 were included. Patient characteristics, laboratory data, radiologic findings, treatments, and complications were analyzed in the study. Results: A total of 249 patients (median age 71, 69.1% male) were included in the study. 28-day mortality was 67.9% (n = 169). The median age of deceased patients was 75 (66–81). Of them, 68.6% were male. Cerebrovascular disease, dementia, chronic kidney disease, and malignancy were significantly higher in the deceased group. In the multivariate analysis, sepsis/septic shock (OR, 15.16, 95% CI, 3.96–58.11, p < 0.001), acute kidney injury (OR, 4.73, 95% CI, 1.55–14.46, p = 0.006), acute cardiac injury (OR, 9.76, 95% CI, 1.84–51.83, p = 0.007), and chest CT score higher than 15 (OR, 4.49, 95% CI, 1.51-13.38, p = 0.007) were independent risk factors for 28-day mortality. Conclusion: Early detection of the risk factors and the use of chest CT score might improve the outcomes in patients with COVID-19.Key words: COVID-19, critical care, tomography, mortality, risk factors, SARS-CoV-2

🔖

Cite This Article

GEZER, N. S., ERGAN, B., GÖKMEN, A. N., CANTÜRK, A., CÖMERT, B., YAKAR, M. N., YAKA, E., KÜÇÜK, M., ERGÜN, B., ERGON, M. C. (2022). Clinical characteristics and risk factors for 28-day mortality in critically ill patients with COVID-19: a retrospective cohort study. Turkish Journal of Medical Sciences, Cilt: 51 - Sayı: 5, 2285–2295. https://ajindex.com/articles/609393

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Huang C, Wang Y, Li X, Ren L, Zhao J et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020
  2. 395 (10223): 497–506. doi: 10.1016/ S0140-6736(20)30183-5 2. World Health Organization (2021). Coronavirus Disease (COVID-19) Dashboard [online]. Website https://covid19. who.int/ [accessed 11 April 2021]. 3. Chidambaram V, Tun NL, Haque WZ, Majella MG, Sivakumar RK et al. Factors associated with disease severity and mortality among patients with COVID-19: A systematic review and meta-analysis. Public Library of Science One 2020
  3. 15 (11): e0241541. doi: 10.1371/journal.pone.0241541 4. Giacomelli A, Ridolfo AL, Milazzo L, Oreni L, Bernacchia D et al. 30-day mortality in patients hospitalized with COVID-19 during the first wave of the Italian epidemic: A prospective cohort study. Pharmacological Research 2020
  4. 104931. doi: 10.1016/j.phrs.2020.104931 5. Gupta S, Hayek SS, Wang W, Chan L, Mathews KS et al. Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US. Journal of the American Medical Association Internal Medicine 2020
  5. 180 (11): 1436– 1447. doi: 10.1001/jamainternmed.2020.3596 6. COVID-ICU Group on behalf of the REVA Network and the COVID-ICU Investigators. Clinical characteristics and day90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study. Intensive Care Medicine 2021
  6. 47 (1): 60–73. doi: 10.1007/s00134-020-06294-x 7. Liu J, Zhang S, Wu Z, Shang Y, Dong X et al. Clinical outcomes of COVID-19 in Wuhan, China: a large cohort study. Annals of Intensive Care 2020
  7. 10 (1): 99. doi: 10.1186/s13613-020- 00706-3 8. Xie J, Wu W, Li S, Hu Y, Hu M et al. Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study. Intensive Care Medicine 2020
  8. 46 (10): 1863–1872. doi: 10.1007/s00134-020-06211-2 9. Kellum JA, Lameire N, Aspelin P, Barsoum RS, Burdmann EA et al. Kidney disease: Improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney International Supplements 2012
  9. 2 (1): 1–138. doi: 10.1038/kisup.2012.1 10. Yang X, Yu Y, Xu J, Shu H, Xia J et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respiratory Medicine 2020
  10. 8 (5): 475–481. doi: 10.1016/S2213-2600