SavedAdd your journal

Journals / Turkish Journal of Endocrinology and Metabolism / 2019 / Cilt: 23 - Sayı: 4

A New Cardiovascular Risk Marker in Men with Hypogonadism: Alanine Aminotransferase

Hipogonadizmli Erkeklerde Yeni Bir Kardiyovasküler Risk Faktörü: Alanin Aminotransferaz

Ayten OĞUZ
Semiha ÇALKAYA
Murat ŞAHİN
Dilek TÜZÜN
Kamile GÜL
Pages
197–205
Publication Date
2022-11-04
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The levels of CIMT, TG, and ALT were significantly higher and that of HDL-C was significantly lower in the patient group0 than the control group (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: We aimed to evaluate the effect of testosterone treatment (TT) on cardiovascular risk markers in male patients with isolated hypogonadotropic hypogonadism (IHH).
📊
Key Findings & Data:Material and Methods: We included 50 men with IHH who were admitted to the Kahramanmaraş Sütçü İmam University Endocrinology and Metabolism Clinic and 43 healthy men (the control group).
💡
Conclusion & Impact:The levels of CIMT, TG, and ALT were significantly higher and that of HDL-C was significantly lower in the patient group0 than the control group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: We aimed to evaluate the effect of testosterone treatment (TT) on cardiovascular risk markers in male patients with isolated hypogonadotropic hypogonadism (IHH). Material and Methods: We included 50 men with IHH who were admitted to the Kahramanmaraş Sütçü İmam University Endocrinology and Metabolism Clinic and 43 healthy men (the control group). The men in the patient group were compared before and after one year of treatment in terms of total testosterone, fasting plasma glucose, alanine aminotransferases (ALT), high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), platelet volume indices [mean platelet volume and platelet distribution width (PDW)], platelet count, and carotid intima-media thickness (CIMT). Moreover, the patient group was compared with the control group. Results: The mean age of the men in the patient and control groups was 31.6 and 29.6 years, respectively. Patients were divided into pre- (patient group0) and posttreatment (patient group1) groups. The levels of CIMT, TG, and ALT were significantly higher and that of HDL-C was significantly lower in the patient group0 than the control group (p

Özet

Amaç: İzole hipogonadotropik hipogonadizm (İHH) li erkek hastalarda testosteron tedavisi (TT) nin kardiyovasküler risk belirteçleri üzerine etkisini değerlendirmektir. Gereç ve Yöntemler: Kahramanmaraş Sütçü İmam Üniversitesi Endokrinoloji ve Metabolizma polikliniğine başvuran ortalama yaşları 31,6 olan İHH’li 50 erkek hasta ve yaş ortalaması 29,6 olan 43 sağlıklı erkek kontrol çalışmaya dâhil edildi. Hasta grubu tedavi öncesi ve 1 yıl sonra ortalama total testosteron, açlık plazma glukozu, alanin aminotransferaz (ALT), trigliserid (TG), düşük yoğunluklu lipoprotein (LDL), yüksek dansiteli lipoprotein (HDL), trombosit hacim endeksleri [ortalama trombosit hacmi (OTH), trombosit dağılım genişliği (TDG)], trombosit sayısı ve karotid intima-media kalınlığı (KİMK) açısından karşılaştırıldı. Ayrıca hasta grubu, kontrol grubu ile karşılaştırıldı. Bulgular: Hasta grubu TT öncesi (hasta grubu0) ve TT sonrası (hasta grubu1) olarak bölündü. Hasta grubunda kontrol grubuna göre KİMK, LDL, TG ve ALT düzeyleri anlamlı olarak yüksek, HDL düzeyleri anlamlı olarak daha düşüktü (p

🔖

Cite This Article

OĞUZ, A., ÇALKAYA, S., ŞAHİN, M., TÜZÜN, D., GÜL, K. (2022). A New Cardiovascular Risk Marker in Men with Hypogonadism: Alanine Aminotransferase. Turkish Journal of Endocrinology and Metabolism, Cilt: 23 - Sayı: 4, 197–205. https://ajindex.com/articles/605401

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (1)

  1. Bianco SD, Kaiser UB. The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism. Nat Rev Endocrinol. 2009;5:569-576. [Crossref] [PubMed] [PMC] 2. Nieschlag E, Swerdloff R, Behre HM, Gooren LJ, Kaufman JM, Legros JJ, Lunenfeld B, Morley JE, Schulman C, Wang C, Weidner W, Wu FC. Investigation, treatment and monitoring of late-onset hypogonadism in males. ISA, ISSAM, and EAU recommendations. Eur Urol. 2005;48:1-4. [Crossref] [PubMed] 3. Khaw KT, Dowsett M, Folkerd E, Bingham S, Wareham N, Luben R, Welch A, Day N. Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study. Circulation. 2007;116:2694-2701. [Crossref] [PubMed] 4. Corona G, Rastrelli G, Di Pasquale G, Sforza A, Mannucci E, Maggi M. Endogenous testosterone levels and cardiovascular risk: meta-analysis of observational studies. J Sex Med. 2018;15:1260-1271. [Crossref] [PubMed] 5. Laughlin GA, Barrett-Connor E, Bergstrom J. Low serum testosterone and mortality in older men. J Clin Endocrinol Metab. 2008;93:68-75. [Crossref] [PubMed] [PMC] 6. Meyer EJ, Wittert G. Endogenous testosterone and mortality risk. Asian J Androl. 2018;20:115-119. [Crossref] [PubMed] [PMC] 7. Haring R, Völzke H, Steveling A, Krebs A, Felix SB, Schöfl C, Dörr M, Nauck M, Wallaschofski H. Low serum testosterone levels are associated with increased risk of mortality in a population-based cohort of men aged 20-79. Eur Heart J. 2010;31:1494-1501. [Crossref] [PubMed] 8. Menke A, Guallar E, Rohrmann S, Nelson WG, Rifai N, Kanarek N, Feinleib M, Michos ED, Dobs A, Platz EA. Sex steroid hormone concentrations and risk of death in US men. Am J Epidemiol. 2010;171:583- 592. [Crossref] [PubMed] [PMC] 9. Guay AT. The emerging link between hypogonadism and metabolic syndrome. J Androl. 2009;30:370- 376. [Crossref] [PubMed] 10.Makhsida N, Shah J, Yan G, Fisch H, Shabsigh R. Hypogonadism and metabolic syndrome: implications for testosterone therapy. J Urol. 2005;174:827- 834. [Crossref] [PubMed] 11. Jones TH. Testosterone deficiency: a risk factor for cardiovascular disease? Trends Endocrinol Metab. 2010;21:496-503. [Crossref] [PubMed] 12.Caughey MC, Qiao Y, Windham BG, Gottesman RF, Mosley TH, Wasserman BA. Carotid intima-media thickness and silent brain infarctions in a biracial cohort: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Hypertens. 2018;31:869-875. [Cross