Journals / Turkish Journal of Endocrinology and Metabolism / 2020 / Cilt: 24 - Sayı: 3

Effects of Isotretinoin Treatment on Levels of Hormones Involved in the Etiopathogenesis of Acne

İzotretinoin Tedavisinin Akne Etiyopatogenezinde Yer Alan Hormon Düzeyleri Üzerindeki Etkileri

Pages
237–246
Publication Date
2022-11-01
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Livertransaminase, low-density lipoprotein (LDL), adrenocorticotropichormone, cortisol, 17-hydroxyprogesterone, and totaltestosterone levels were different in the patient group comparedto the control group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study was performed to measure the effectof isotretinoin treatment on hormonal responses and insulinresistance in acne patients.
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Key Findings & Data:Material and Methods: A totalof 30 acne vulgaris patients and 30 control group volunteerswere examined between February 2015 and June 2015.Firstly, the basal insulin resistance and endocrine hormonelevels were measured in both groups.
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Conclusion & Impact:Livertransaminase, low-density lipoprotein (LDL), adrenocorticotropichormone, cortisol, 17-hydroxyprogesterone, and totaltestosterone levels were different in the patient group comparedto the control group (p
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: This study was performed to measure the effectof isotretinoin treatment on hormonal responses and insulinresistance in acne patients. Material and Methods: A totalof 30 acne vulgaris patients and 30 control group volunteerswere examined between February 2015 and June 2015.Firstly, the basal insulin resistance and endocrine hormonelevels were measured in both groups. A daily dose of 120–150 mg/kg oral isotretinoin was administered to the patientgroup for three months. Following this, insulin resistance andendocrine hormone levels were re-evaluated in both groups.Results: Age, waist circumference, and body mass indexwere similar between the patient and control groups. Livertransaminase, low-density lipoprotein (LDL), adrenocorticotropichormone, cortisol, 17-hydroxyprogesterone, and totaltestosterone levels were different in the patient group comparedto the control group (p

Özet

Amaç: Bu çalışma, akne hastalarında izotretinoin tedavisinin hormonal yanıt ve insülin direnci üzerindeki etkisini ölçmek amacıyla planlanmıştır. Gereç ve Yöntemler: Şubat 2015-Haziran 2015 tarihleri arasında toplam 30 akne vulgaris hastası ve 30 gönüllü kontrol grubu incelendi. İlk olarak, her iki grupta bazal insülin direnci ve endokrin hormon düzeyleri ölçüldü. Üç ay boyunca hasta grubuna günde 120- 150 mg/kg oral izotretinoin uygulandı. Bunu takiben her iki grupta da insülin direnci ve endokrin hormon düzeyleri yeniden değerlendirildi. Bulgular: Hasta ve kontrol grubu arasında yaş, bel çevresi ve beden kitle indeksi benzerdi. Hasta grubunda karaciğer transaminazları, “low-density lipoprotein (LDL)”, adrenokortikotropik hormon, kortizol, 17-hidroksiprogesteron ve total testosteron düzeyleri kontrol grubuna göre farklıydı (p

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Cite This Article

KOÇYİĞİT, S. E., ŞAHİN, M., ÇORAPÇIOĞLU, D., HOUSHYAR, Y., GÜNAY, F. S. D. (2022). Effects of Isotretinoin Treatment on Levels of Hormones Involved in the Etiopathogenesis of Acne. Turkish Journal of Endocrinology and Metabolism, Cilt: 24 - Sayı: 3, 237–246. https://ajindex.com/articles/605392

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