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Journals / Turkish Journal of Chemistry / 2017 / Cilt: 41 - Sayı: 6

Investigation of photoinduced polymerization of doxycycline-imprinted hydrogels: effect of template on initiator reactivity, conversion, and reaction rate

Fatma Seniha GÜNER
Dilek DALGAKIRAN
Tuğçe INAN
Pages
862–873
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

All results showed that there is a signi cant effect of DOX concentration on the conversion and reaction rate of the photopolymerization reaction.

📌 3 Key Takeaways

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Objective & Hypothesis:Photopolymerization kinetics of doxycycline hyclate (DOX)-imprinted hydrogels were monitored by real-time Fourier transform infrared spectroscopy and differential photocalorimetry. 2-Hydroxyethyl methacrylate-based hydrogels were synthesized by using ethylene glycol dimethacrylate as a cross-linker, acrylic acid (AA) as a functional monomer, and 2,2-dimethyl-2-hydroxy acetophenone as a photoinitiator.
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Key Findings & Data:For imprinting DOX in hydrogels, the molar ratio of template to functional monomer (DOX:AA) was chosen as 1:8 and 1:16.
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Conclusion & Impact:All results showed that there is a signi cant effect of DOX concentration on the conversion and reaction rate of the photopolymerization reaction.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Photopolymerization kinetics of doxycycline hyclate (DOX)-imprinted hydrogels were monitored by real-time Fourier transform infrared spectroscopy and differential photocalorimetry. 2-Hydroxyethyl methacrylate-based hydrogels were synthesized by using ethylene glycol dimethacrylate as a cross-linker, acrylic acid (AA) as a functional monomer, and 2,2-dimethyl-2-hydroxy acetophenone as a photoinitiator. For imprinting DOX in hydrogels, the molar ratio of template to functional monomer (DOX:AA) was chosen as 1:8 and 1:16. The polymerization was achieved at two different initiator concentrations. The conversion and reaction rate were calculated as a function of the molar ratio of template, and the results were compared to those of nonimprinted ones. In order to reveal the effect of DOX on the photoinduced radical polymerization, thermal polymerization was also performed for imprinted and nonimprinted hydrogels by using 2,2 ′ - azobis(2,4-dimethyl-pentanenitrile) as a thermal initiator. All results showed that there is a signi cant effect of DOX concentration on the conversion and reaction rate of the photopolymerization reaction. The conversion and reaction rate decreased during photopolymerization when the template concentration increased in the monomer mixture.

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Cite This Article

GÜNER, F. S., DALGAKIRAN, D., INAN, T. (2022). Investigation of photoinduced polymerization of doxycycline-imprinted hydrogels: effect of template on initiator reactivity, conversion, and reaction rate. Turkish Journal of Chemistry, Cilt: 41 - Sayı: 6, 862–873. https://ajindex.com/articles/601861

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