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Journals / Turkish Journal of Chemistry / 2018 / Cilt: 42 - Sayı: 6

Recent synthetic methodologies for pyrimidine and its derivatives

Matloob AHMAD
Farhat IBRAHEEM
Furqan Ahmad SADDIQUE
Asim MANSHA
Sana ASLAM
Tahir FAROOQ
Pages
1421–1458
Publication Date
2022-11-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this context, the present reviewillustrates a variety of novel and efficient synthetic approaches towards the synthesis of pyrimidine and its derivativesthat were reported recently.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Pyrimidine derivatives are well known due to their remarkable pharmacological potential in various fields ofscience, and they are also present in some natural substances like DNA and RNA.
📊
Key Findings & Data:These scaffolds manifest diversifiedbiological activities such as antimicrobial, antiinflammatory, anti-HIV, antitubercular, antitumor, antineoplastic, andantimalarial.
💡
Conclusion & Impact:In this context, the present reviewillustrates a variety of novel and efficient synthetic approaches towards the synthesis of pyrimidine and its derivativesthat were reported recently.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Pyrimidine derivatives are well known due to their remarkable pharmacological potential in various fields ofscience, and they are also present in some natural substances like DNA and RNA. These scaffolds manifest diversifiedbiological activities such as antimicrobial, antiinflammatory, anti-HIV, antitubercular, antitumor, antineoplastic, andantimalarial. A pyrimidine ring is constructed when chalcones, amidines, guanidine, nitriles, isocyanates, urea, thiourea,and aminopyrazoles undergo condensation, coupling, or cyclization reactions. In this context, the present reviewillustrates a variety of novel and efficient synthetic approaches towards the synthesis of pyrimidine and its derivativesthat were reported recently.

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Cite This Article

AHMAD, M., IBRAHEEM, F., SADDIQUE, F. A., MANSHA, A., ASLAM, S., FAROOQ, T. (2022). Recent synthetic methodologies for pyrimidine and its derivatives. Turkish Journal of Chemistry, Cilt: 42 - Sayı: 6, 1421–1458. https://ajindex.com/articles/601821

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